Abstract
Accepted 6 May 1997
The proinflammatory cytokines tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and IL-8 were measured in plasma and urine samples from 19 children with verocytotoxin-producing Escherichia coli (VTEC) induced haemolytic uraemic syndrome (HUS) and 30 controls. TNF-α was detected in the plasma of two cases and one control; IL-6 in the plasma of one, and the urine of two cases, and in the plasma of one control. IL-1β and IL-8 were each identified in eight of the 19 cases and in one and two controls respectively. Urinary IL-8 was found in seven cases, four of whom had plasma concentrations below the limit of detection suggesting renal secretion of this cytokine. Cytokine concentrations did not correlate with peripheral blood neutrophil count at onset of disease. These data confirm the systemic release of cytokines responsible for the coordination of acute inflammatory processes in some children with VTEC induced HUS.
Full Text
The Full Text of this article is available as a PDF (84.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Coad N. A., Marshall T., Rowe B., Taylor C. M. Changes in the postenteropathic form of the hemolytic uremic syndrome in children. Clin Nephrol. 1991 Jan;35(1):10–16. [PubMed] [Google Scholar]
- Fitzpatrick M. M., Shah V., Trompeter R. S., Dillon M. J., Barratt T. M. Interleukin-8 and polymorphoneutrophil leucocyte activation in hemolytic uremic syndrome of childhood. Kidney Int. 1992 Oct;42(4):951–956. doi: 10.1038/ki.1992.372. [DOI] [PubMed] [Google Scholar]
- Inward C. D., Williams J., Chant I., Crocker J., Milford D. V., Rose P. E., Taylor C. M. Verocytotoxin-1 induces apoptosis in vero cells. J Infect. 1995 May;30(3):213–218. doi: 10.1016/s0163-4453(95)90693-2. [DOI] [PubMed] [Google Scholar]
- Karpman D., Andreasson A., Thysell H., Kaplan B. S., Svanborg C. Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Pediatr Nephrol. 1995 Dec;9(6):694–699. doi: 10.1007/BF00868714. [DOI] [PubMed] [Google Scholar]
- López E. L., Contrini M. M., Devoto S., de Rosa M. F., Graña M. G., Genero M. H., Canepa C., Gomez H. F., Cleary T. G. Tumor necrosis factor concentrations in hemolytic uremic syndrome patients and children with bloody diarrhea in Argentina. Pediatr Infect Dis J. 1995 Jul;14(7):594–598. doi: 10.1097/00006454-199507000-00008. [DOI] [PubMed] [Google Scholar]
- Pavia A. T., Nichols C. R., Green D. P., Tauxe R. V., Mottice S., Greene K. D., Wells J. G., Siegler R. L., Brewer E. D., Hannon D. Hemolytic-uremic syndrome during an outbreak of Escherichia coli O157:H7 infections in institutions for mentally retarded persons: clinical and epidemiologic observations. J Pediatr. 1990 Apr;116(4):544–551. doi: 10.1016/s0022-3476(05)81600-2. [DOI] [PubMed] [Google Scholar]
- Wada T., Tomosugi N., Naito T., Yokoyama H., Kobayashi K., Harada A., Mukaida N., Matsushima K. Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis. J Exp Med. 1994 Sep 1;180(3):1135–1140. doi: 10.1084/jem.180.3.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walters M. D., Matthei I. U., Kay R., Dillon M. J., Barratt T. M. The polymorphonuclear leucocyte count in childhood haemolytic uraemic syndrome. Pediatr Nephrol. 1989 Apr;3(2):130–134. doi: 10.1007/BF00852893. [DOI] [PubMed] [Google Scholar]
- Wozniak A., Betts W. H., Murphy G. A., Rokicinski M. Interleukin-8 primes human neutrophils for enhanced superoxide anion production. Immunology. 1993 Aug;79(4):608–615. [PMC free article] [PubMed] [Google Scholar]
- van de Kar N. C., Sauerwein R. W., Demacker P. N., Grau G. E., van Hinsbergh V. W., Monnens L. A. Plasma cytokine levels in hemolytic uremic syndrome. Nephron. 1995;71(3):309–313. doi: 10.1159/000188737. [DOI] [PubMed] [Google Scholar]