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. 1990 May;34(5):939–940. doi: 10.1128/aac.34.5.939

Double-blind, randomized, controlled clinical trial of norfloxacin for cholera.

S K Bhattacharya 1, M K Bhattacharya 1, P Dutta 1, D Dutta 1, S P De 1, S N Sikdar 1, A Maitra 1, A Dutta 1, S C Pal 1
PMCID: PMC171728  PMID: 2193628

Abstract

In a double-blind, randomized clinical trial with 78 adults with acute watery diarrhea and severe dehydration, 37 subjects were positive for Vibrio cholerae. In conjunction with rehydration therapy, 13 patients received norfloxacin, 12 received trimethoprim-sulfamethoxazole (TMP-SMX), and 12 received a placebo. Norfloxacin was superior to TMP-SMX and to the placebo in reducing stool output, duration of diarrhea, fluid requirements, and vibrio excretion. TMP-SMX was no better than the placebo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Francis T. I., Lewis E. A., Oyediran A. B., Okubadejo O. A., Montefiore D., Onyewotu I. I., Mohammed I., Ayoola E. A., Vincent R. Effect of chemotherapy on the duration of diarrhoea, and on vibrio excretion by cholera patients. J Trop Med Hyg. 1971 Aug;74(8):172–176. [PubMed] [Google Scholar]
  3. Morris J. G., Jr, Tenney J. H., Drusano G. L. In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents. Antimicrob Agents Chemother. 1985 Sep;28(3):442–445. doi: 10.1128/aac.28.3.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Pierce N. F., Banwell J. G., Mitra R. C., Caranasos G. J., Keimowitz R. I., Thomas J., Mondal A. Controlled comparison of tetracycline and furazolidone in cholera. Br Med J. 1968 Aug 3;3(5613):277–280. doi: 10.1136/bmj.3.5613.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Sen D., Saha M. R., Niyogi S. K., Nair G. B., De S. P., Datta P., Datta D., Pal S. C., Bose R., Roychowdhury J. Aetiological studies on hospital in-patients with acute diarrhoea in Calcutta. Trans R Soc Trop Med Hyg. 1983;77(2):212–214. doi: 10.1016/0035-9203(83)90073-1. [DOI] [PubMed] [Google Scholar]
  6. Shungu D. L., Weinberg E., Gadebusch H. H. In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens. Antimicrob Agents Chemother. 1983 Jan;23(1):86–90. doi: 10.1128/aac.23.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Wallace C. K., Anderson P. N., Brown T. C., Khanra S. R., Lewis G. W., Pierce N. F., Sanyal S. N., Segre G. V., Waldman R. H. Optimal antibiotic therapy in cholera. Bull World Health Organ. 1968;39(2):239–245. [PMC free article] [PubMed] [Google Scholar]

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