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. 1997 Nov;77(5):441–444. doi: 10.1136/adc.77.5.441

Hyperammonaemia with distal renal tubular acidosis

S Miller 1, G Schwartz 1
PMCID: PMC1717366  PMID: 9487970

Abstract





The case is reported of an infant with hyperammonaemia secondary to severe distal renal tubular acidosis. A clinical association between increased concentrations of ammonia in serum and renal tubular acidosis has not previously been described. In response to acidosis the infant's kidneys presumably increased ammonia synthesis but did not excrete ammonia, resulting in hyperammonaemia. The patient showed poor feeding, frequent vomiting, and failure to thrive, but did not have an inborn error of metabolism. This case report should alert doctors to consider renal tubular acidosis in the differential diagnosis of severely ill infants with metabolic acidosis and hyperammonaemia.



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Selected References

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