Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1997 Dec;77(6):530–534. doi: 10.1136/adc.77.6.530

Pathogenesis of juvenile chronic arthritis: genetic and environmental factors

K Murray 1, S Thompson 1, D Glass 1
PMCID: PMC1717420  PMID: 9496193

Full Text

The Full Text of this article is available as a PDF (99.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adachi M., Watanabe-Fukunaga R., Nagata S. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1756–1760. doi: 10.1073/pnas.90.5.1756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boivin G. P., O'Toole B. A., Orsmby I. E., Diebold R. J., Eis M. J., Doetschman T., Kier A. B. Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice. Am J Pathol. 1995 Jan;146(1):276–288. [PMC free article] [PubMed] [Google Scholar]
  3. Clemens L. E., Albert E., Ansell B. M. Sibling pairs affected by chronic arthritis of childhood: evidence for a genetic predisposition. J Rheumatol. 1985 Feb;12(1):108–113. [PubMed] [Google Scholar]
  4. Davies E. J., Hutchings C. J., Hillarby M. C., Donn R. P., Cooper R. G., Hay E. M., Bernstein R. M., Holt P. J., Grennan D. M., Ollier W. E. HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus. Ann Rheum Dis. 1994 Mar;53(3):188–190. doi: 10.1136/ard.53.3.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davies J. L., Kawaguchi Y., Bennett S. T., Copeman J. B., Cordell H. J., Pritchard L. E., Reed P. W., Gough S. C., Jenkins S. C., Palmer S. M. A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 1994 Sep 8;371(6493):130–136. doi: 10.1038/371130a0. [DOI] [PubMed] [Google Scholar]
  6. De Inocencio J., Giannini E. H., Glass D. N. Can genetic markers contribute to the classification of juvenile rheumatoid arthritis? J Rheumatol Suppl. 1993 Oct;40:12–18. [PubMed] [Google Scholar]
  7. Donn R. P., Davies E. J., Holt P. L., Thomson W., Ollier W. Increased frequency of TAP2B in early onset pauciarticular juvenile chronic arthritis. Ann Rheum Dis. 1994 Apr;53(4):261–264. doi: 10.1136/ard.53.4.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fearon D. T., Locksley R. M. The instructive role of innate immunity in the acquired immune response. Science. 1996 Apr 5;272(5258):50–53. doi: 10.1126/science.272.5258.50. [DOI] [PubMed] [Google Scholar]
  9. Fink C. W. Proposal for the development of classification criteria for idiopathic arthritides of childhood. J Rheumatol. 1995 Aug;22(8):1566–1569. [PubMed] [Google Scholar]
  10. Fisher G. H., Rosenberg F. J., Straus S. E., Dale J. K., Middleton L. A., Lin A. Y., Strober W., Lenardo M. J., Puck J. M. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. 1995 Jun 16;81(6):935–946. doi: 10.1016/0092-8674(95)90013-6. [DOI] [PubMed] [Google Scholar]
  11. Giannini E. H., Malagon C. N., Van Kerckhove C., Taylor J., Lovell D. J., Levinson J. E., Passo M. H., Ginsberg J., Burke M. J., Glass D. N. Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis. J Rheumatol. 1991 Sep;18(9):1394–1397. [PubMed] [Google Scholar]
  12. Grom A. A., Giannini E. H., Glass D. N. Juvenile rheumatoid arthritis and the trimolecular complex (HLA, T cell receptor, and antigen). Differences from rheumatoid arthritis. Arthritis Rheum. 1994 May;37(5):601–607. doi: 10.1002/art.1780370501. [DOI] [PubMed] [Google Scholar]
  13. Grom A. A., Thompson S. D., Luyrink L., Passo M., Choi E., Glass D. N. Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11104–11108. doi: 10.1073/pnas.90.23.11104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Haas J. P., Kimura A., Truckenbrodt H., Suschke J., Sasazuki T., Volgger A., Albert E. D. Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter. Tissue Antigens. 1995 May;45(5):317–321. doi: 10.1111/j.1399-0039.1995.tb02460.x. [DOI] [PubMed] [Google Scholar]
  15. Haas J. P., Nevinny-Stickel C., Schoenwald U., Truckenbrodt H., Suschke J., Albert E. D. Susceptible and protective major histocompatibility complex class II alleles in early-onset pauciarticular juvenile chronic arthritis. Hum Immunol. 1994 Nov;41(3):225–233. doi: 10.1016/0198-8859(94)90040-x. [DOI] [PubMed] [Google Scholar]
  16. Life P., Hassell A., Williams K., Young S., Bacon P., Southwood T., Gaston J. S. Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60. J Rheumatol. 1993 Aug;20(8):1388–1396. [PubMed] [Google Scholar]
  17. Luyrink L., Gabriel C. A., Thompson S. D., Grom A. A., Maksymowych W. P., Choi E., Glass D. N. Reduced expression of a human V beta 6.1 T-cell receptor allele. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4369–4373. doi: 10.1073/pnas.90.10.4369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Maximov A. A., Shaikov A. V., Lovell D. J., Giannini E. H., Soldatova S. I. Chlamydial associated syndrome of arthritis and eye involvement in young children. J Rheumatol. 1992 Nov;19(11):1794–1797. [PubMed] [Google Scholar]
  19. McDowell T. L., Symons J. A., Ploski R., Førre O., Duff G. W. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 alpha polymorphism. Arthritis Rheum. 1995 Feb;38(2):221–228. doi: 10.1002/art.1780380210. [DOI] [PubMed] [Google Scholar]
  20. Murray K. J., Szer W., Grom A. A., Donnelly P., Levinson J. E., Giannini E. H., Glass D. N., Szer I. S. Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. J Rheumatol. 1997 Mar;24(3):560–567. [PubMed] [Google Scholar]
  21. Nepom B. The immunogenetics of juvenile rheumatoid arthritis. Rheum Dis Clin North Am. 1991 Nov;17(4):825–842. [PubMed] [Google Scholar]
  22. Oen K., Fast M., Postl B. Epidemiology of juvenile rheumatoid arthritis in Manitoba, Canada, 1975-92: cycles in incidence. J Rheumatol. 1995 Apr;22(4):745–750. [PubMed] [Google Scholar]
  23. Pablos J. L., Poveda M. J., Ciruelo E., Palenque E., Alonso J., Mateo I. Cutaneous infection with rapidly growing mycobacteria in patients with systemic rheumatic disease. Clin Exp Rheumatol. 1994 Sep-Oct;12(5):535–537. [PubMed] [Google Scholar]
  24. Pociot F., D'Alfonso S., Compasso S., Scorza R., Richiardi P. M. Functional analysis of a new polymorphism in the human TNF alpha gene promoter. Scand J Immunol. 1995 Oct;42(4):501–504. doi: 10.1111/j.1365-3083.1995.tb03686.x. [DOI] [PubMed] [Google Scholar]
  25. Prakken A. B., van Eden W., Rijkers G. T., Kuis W., Toebes E. A., de Graeff-Meeder E. R., van der Zee R., Zegers B. J. Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. Arthritis Rheum. 1996 Nov;39(11):1826–1832. doi: 10.1002/art.1780391108. [DOI] [PubMed] [Google Scholar]
  26. Pritchard M. H., Matthews N., Munro J. Antibodies to influenza A in a cluster of children with juvenile chronic arthritis. Br J Rheumatol. 1988 Jun;27(3):176–180. doi: 10.1093/rheumatology/27.3.176. [DOI] [PubMed] [Google Scholar]
  27. Pryhuber K. G., Murray K. J., Donnelly P., Passo M. H., Maksymowych W. P., Glass D. N., Giannini E. H., Colbert R. A. Polymorphism in the LMP2 gene influences disease susceptibility and severity in HLA-B27 associated juvenile rheumatoid arthritis. J Rheumatol. 1996 Apr;23(4):747–752. [PubMed] [Google Scholar]
  28. Rossen R. D., Brewer E. J., Sharp R. M., Ott J., Templeton J. W. Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis. J Clin Invest. 1980 Mar;65(3):629–642. doi: 10.1172/JCI109708. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  30. Shaw M. A., Clayton D., Atkinson S. E., Williams H., Miller N., Sibthorpe D., Blackwell J. M. Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. J Med Genet. 1996 Aug;33(8):672–677. doi: 10.1136/jmg.33.8.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Sioud M., Førre O., Dybwad A. Selection of ligands for polyclonal antibodies from random peptide libraries: potential identification of (auto)antigens that may trigger B and T cell responses in autoimmune diseases. Clin Immunol Immunopathol. 1996 May;79(2):105–114. doi: 10.1006/clin.1996.0057. [DOI] [PubMed] [Google Scholar]
  32. Walley A. J., Cookson W. O. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet. 1996 Aug;33(8):689–692. doi: 10.1136/jmg.33.8.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Walser-Kuntz D. R., Weyand C. M., Fulbright J. W., Moore S. B., Goronzy J. J. HLA-DRB1 molecules and antigenic experience shape the repertoire of CD4 T cells. Hum Immunol. 1995 Dec;44(4):203–209. doi: 10.1016/0198-8859(95)00109-3. [DOI] [PubMed] [Google Scholar]
  34. Weyand C. M., Goronzy J. J. Pathogenesis of rheumatoid arthritis. Med Clin North Am. 1997 Jan;81(1):29–55. doi: 10.1016/s0025-7125(05)70504-6. [DOI] [PubMed] [Google Scholar]
  35. de Graeff-Meeder E. R., van Eden W., Rijkers G. T., Prakken B. J., Kuis W., Voorhorst-Ogink M. M., van der Zee R., Schuurman H. J., Helders P. J., Zegers B. J. Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. J Clin Invest. 1995 Mar;95(3):934–940. doi: 10.1172/JCI117801. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES