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. 1990 Jun;34(6):1017–1019. doi: 10.1128/aac.34.6.1017

Concentrations of oral lomefloxacin in serum and bronchial mucosa.

D R Baldwin 1, D Honeybourne 1, J M Andrews 1, J P Ashby 1, R Wise 1
PMCID: PMC171749  PMID: 2393260

Abstract

The bronchial mucosal concentrations of lomefloxacin were determined for specimens obtained by fiber-optic bronchoscopy and compared with simultaneous concentrations in serum. The 23 patients studied were given an oral dose of 400 mg once daily for 4 days to achieve steady-state levels. The median concentration in serum was 2.5 micrograms/ml (range, 1.0 to 5 micrograms/ml), and the median bronchial mucosal concentration was 5.0 micrograms/g (range, 0.7 to 18.6 micrograms/g). The median percent penetration was 177% (range, 69 to 541%). The concentrations in serum and mucosa exceeded the MIC for 90% of strains of organisms causing bronchial infections but not sufficiently to recommend lomefloxacin for the routine treatment of pneumococcal infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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