Abstract
Three children (two girls aged 7 and 9 years, and one boy aged 4 years) with diuretic resistant oedema in steroid resistant nephrotic syndrome were treated with a combination of intravenous mannitol and frusemide. All three responded with loss of oedema of 10% to 30% of body weight over one week. There were no complications of hypertension or hypovolaemia. Mannitol-frusemide combination is a safe, inexpensive, and effective treatment for diuretic resistant oedema. Its use in other conditions and in developing countries (where the availability and purity of 20% albumin is limited) needs to be explored.
Full Text
The Full Text of this article is available as a PDF (49.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arnold W. C. Efficacy of metolazone and furosemide in children with furosemide-resistant edema. Pediatrics. 1984 Nov;74(5):872–875. [PubMed] [Google Scholar]
- Better O. S., Rubinstein I., Winaver J. M., Knochel J. P. Mannitol therapy revisited (1940-1997). Kidney Int. 1997 Oct;52(4):886–894. doi: 10.1038/ki.1997.409. [DOI] [PubMed] [Google Scholar]
- Glassock R. J. Management of intractable edema in nephrotic syndrome. Kidney Int Suppl. 1997 Mar;58:S75–S79. [PubMed] [Google Scholar]
- Haws R. M., Baum M. Efficacy of albumin and diuretic therapy in children with nephrotic syndrome. Pediatrics. 1993 Jun;91(6):1142–1146. [PubMed] [Google Scholar]