Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1999 Oct;81(4):360–364. doi: 10.1136/adc.81.4.360

Bone growth mechanisms and the effects of cytotoxic drugs

H Robson 1
PMCID: PMC1718097  PMID: 10490447

Full Text

The Full Text of this article is available as a PDF (93.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abad V., Uyeda J. A., Temple H. T., De Luca F., Baron J. Determinants of spatial polarity in the growth plate. Endocrinology. 1999 Feb;140(2):958–962. doi: 10.1210/endo.140.2.6513. [DOI] [PubMed] [Google Scholar]
  2. Ahmed S. F., Wallace W. H., Kelnar C. J. An anthropometric study of children during intensive chemotherapy for acute lymphoblastic leukaemia. Horm Res. 1997;48(4):178–183. doi: 10.1159/000185510. [DOI] [PubMed] [Google Scholar]
  3. Allen D. B. Growth suppression by glucocorticoid therapy. Endocrinol Metab Clin North Am. 1996 Sep;25(3):699–717. doi: 10.1016/s0889-8529(05)70348-0. [DOI] [PubMed] [Google Scholar]
  4. Altman A., Hochberg Z., Silbermann M. Interactions between growth hormone and dexamethasone in skeletal growth and bone structure of the young mouse. Calcif Tissue Int. 1992 Oct;51(4):298–304. doi: 10.1007/BF00334491. [DOI] [PubMed] [Google Scholar]
  5. Bar-On E., Beckwith J. B., Odom L. F., Eilert R. E. Effect of chemotherapy on human growth plate. J Pediatr Orthop. 1993 Mar-Apr;13(2):220–224. [PubMed] [Google Scholar]
  6. Baron J., Klein K. O., Colli M. J., Yanovski J. A., Novosad J. A., Bacher J. D., Cutler G. B., Jr Catch-up growth after glucocorticoid excess: a mechanism intrinsic to the growth plate. Endocrinology. 1994 Oct;135(4):1367–1371. doi: 10.1210/endo.135.4.7925098. [DOI] [PubMed] [Google Scholar]
  7. Caruso-Nicoletti M., Mancuso M., Spadaro G., Dibenedetto S. P., DiCataldo A., Schiliró G. Growth and growth hormone in children during and after therapy for acute lymphoblastic leukaemia. Eur J Pediatr. 1993 Sep;152(9):730–733. doi: 10.1007/BF01953986. [DOI] [PubMed] [Google Scholar]
  8. Clayton P. E., Shalet S. M., Morris-Jones P. H., Price D. A. Growth in children treated for acute lymphoblastic leukaemia. Lancet. 1988 Feb 27;1(8583):460–462. doi: 10.1016/s0140-6736(88)91246-9. [DOI] [PubMed] [Google Scholar]
  9. Coleman R. E. Glucocorticoids in cancer therapy. Biotherapy. 1992;4(1):37–44. doi: 10.1007/BF02171708. [DOI] [PubMed] [Google Scholar]
  10. Crofton P. M., Ahmed S. F., Wade J. C., Stephen R., Elmlinger M. W., Ranke M. B., Kelnar C. J., Wallace W. H. Effects of intensive chemotherapy on bone and collagen turnover and the growth hormone axis in children with acute lymphoblastic leukemia. J Clin Endocrinol Metab. 1998 Sep;83(9):3121–3129. doi: 10.1210/jcem.83.9.5133. [DOI] [PubMed] [Google Scholar]
  11. Glasser D. B., Duane K., Lane J. M., Healey J. H., Caparros-Sison B. The effect of chemotherapy on growth in the skeletally immature individual. Clin Orthop Relat Res. 1991 Jan;(262):93–100. [PubMed] [Google Scholar]
  12. Green H., Morikawa M., Nixon T. A dual effector theory of growth-hormone action. Differentiation. 1985;29(3):195–198. doi: 10.1111/j.1432-0436.1985.tb00316.x. [DOI] [PubMed] [Google Scholar]
  13. Holm K., Nysom K., Hertz H., Müller J. Normal final height after treatment for acute lymphoblastic leukemia without irradiation. Acta Paediatr. 1994 Dec;83(12):1287–1290. doi: 10.1111/j.1651-2227.1994.tb13018.x. [DOI] [PubMed] [Google Scholar]
  14. Hunziker E. B. Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc Res Tech. 1994 Aug 15;28(6):505–519. doi: 10.1002/jemt.1070280606. [DOI] [PubMed] [Google Scholar]
  15. Jux C., Leiber K., Hügel U., Blum W., Ohlsson C., Klaus G., Mehls O. Dexamethasone impairs growth hormone (GH)-stimulated growth by suppression of local insulin-like growth factor (IGF)-I production and expression of GH- and IGF-I-receptor in cultured rat chondrocytes. Endocrinology. 1998 Jul;139(7):3296–3305. doi: 10.1210/endo.139.7.6099. [DOI] [PubMed] [Google Scholar]
  16. Kember N. F. Cell kinetics and the control of growth in long bones. Cell Tissue Kinet. 1978 Sep;11(5):477–485. doi: 10.1111/j.1365-2184.1978.tb00820.x. [DOI] [PubMed] [Google Scholar]
  17. Kirk J. A., Raghupathy P., Stevens M. M., Cowell C. T., Menser M. A., Bergin M., Tink A., Vines R. H., Silink M. Growth failure and growth-hormone deficiency after treatment for acute lymphoblastic leukaemia. Lancet. 1987 Jan 24;1(8526):190–193. doi: 10.1016/s0140-6736(87)90004-3. [DOI] [PubMed] [Google Scholar]
  18. Lannering B., Albertsson-Wikland K. Improved growth response to GH treatment in irradiated children. Acta Paediatr Scand. 1989 Jul;78(4):562–567. doi: 10.1111/j.1651-2227.1989.tb17937.x. [DOI] [PubMed] [Google Scholar]
  19. Lanske B., Karaplis A. C., Lee K., Luz A., Vortkamp A., Pirro A., Karperien M., Defize L. H., Ho C., Mulligan R. C. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 1996 Aug 2;273(5275):663–666. doi: 10.1126/science.273.5275.663. [DOI] [PubMed] [Google Scholar]
  20. Lindahl A., Isgaard J., Carlsson L., Isaksson O. G. Differential effects of growth hormone and insulin-like growth factor I on colony formation of epiphyseal chondrocytes in suspension culture in rats of different ages. Endocrinology. 1987 Sep;121(3):1061–1069. doi: 10.1210/endo-121-3-1061. [DOI] [PubMed] [Google Scholar]
  21. Lindahl A., Isgaard J., Nilsson A., Isaksson O. G. Growth hormone potentiates colony formation of epiphyseal chondrocytes in suspension culture. Endocrinology. 1986 May;118(5):1843–1848. doi: 10.1210/endo-118-5-1843. [DOI] [PubMed] [Google Scholar]
  22. Mohnike K., Dörffel W., Timme J., Kluba U., Aumann V., Vorwerk P., Mittler U. Final height and puberty in 40 patients after antileukaemic treatment during childhood. Eur J Pediatr. 1997 Apr;156(4):272–276. doi: 10.1007/s004310050599. [DOI] [PubMed] [Google Scholar]
  23. Oberbauer A. M., Peng R. Growth hormone and IGF-I stimulate cell function in distinct zones of the rat epiphyseal growth plate. Connect Tissue Res. 1995;31(3):189–195. doi: 10.3109/03008209509010810. [DOI] [PubMed] [Google Scholar]
  24. Ogilvy-Stuart A. L., Shalet S. M. Growth and puberty after growth hormone treatment after irradiation for brain tumours. Arch Dis Child. 1995 Aug;73(2):141–146. doi: 10.1136/adc.73.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Ohlsson C., Bengtsson B. A., Isaksson O. G., Andreassen T. T., Slootweg M. C. Growth hormone and bone. Endocr Rev. 1998 Feb;19(1):55–79. doi: 10.1210/edrv.19.1.0324. [DOI] [PubMed] [Google Scholar]
  26. Olshan J. S., Gubernick J., Packer R. J., D'Angio G. J., Goldwein J. W., Willi S. M., Moshang T., Jr The effects of adjuvant chemotherapy on growth in children with medulloblastoma. Cancer. 1992 Oct 1;70(7):2013–2017. doi: 10.1002/1097-0142(19921001)70:7<2013::aid-cncr2820700734>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  27. Poole A. R., Pidoux I., Reiner A., Rosenberg L., Hollister D., Murray L., Rimoin D. Kniest dysplasia is characterized by an apparent abnormal processing of the C-propeptide of type II cartilage collagen resulting in imperfect fibril assembly. J Clin Invest. 1988 Feb;81(2):579–589. doi: 10.1172/JCI113356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Price J. S., Oyajobi B. O., Russell R. G. The cell biology of bone growth. Eur J Clin Nutr. 1994 Feb;48 (Suppl 1):S131–S149. [PubMed] [Google Scholar]
  29. Robson H., Anderson E., Eden O. B., Isaksson O., Shalet S. Chemotherapeutic agents used in the treatment of childhood malignancies have direct effects on growth plate chondrocyte proliferation. J Endocrinol. 1998 May;157(2):225–235. doi: 10.1677/joe.0.1570225. [DOI] [PubMed] [Google Scholar]
  30. Samuelsson B. O., Márky I., Rosberg S., Albertsson-Wikland K. Growth and growth hormone secretion after treatment for childhood non-Hodgkin's lymphoma. Med Pediatr Oncol. 1997 Jan;28(1):27–34. doi: 10.1002/(sici)1096-911x(199701)28:1<27::aid-mpo6>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  31. Schriock E. A., Schell M. J., Carter M., Hustu O., Ochs J. J. Abnormal growth patterns and adult short stature in 115 long-term survivors of childhood leukemia. J Clin Oncol. 1991 Mar;9(3):400–405. doi: 10.1200/JCO.1991.9.3.400. [DOI] [PubMed] [Google Scholar]
  32. Shalet S. M., Whitehead E., Chapman A. J., Beardwell C. G. The effects of growth hormone therapy in children with radiation-induced growth hormone deficiency. Acta Paediatr Scand. 1981 Jan;70(1):81–86. doi: 10.1111/j.1651-2227.1981.tb07177.x. [DOI] [PubMed] [Google Scholar]
  33. Shapiro I. M., Mansfield K. D., Evans S. M., Lord E. M., Koch C. J. Chondrocytes in the endochondral growth cartilage are not hypoxic. Am J Physiol. 1997 Apr;272(4 Pt 1):C1134–C1143. doi: 10.1152/ajpcell.1997.272.4.C1134. [DOI] [PubMed] [Google Scholar]
  34. Thun-Hohenstein L., Frisch H., Schuster E. Growth after radiotherapy and chemotherapy in children with leukemia or lymphoma. Horm Res. 1992;37(3):91–95. doi: 10.1159/000182289. [DOI] [PubMed] [Google Scholar]
  35. VAN METRE T. E., Jr, PINKERTON H. L., Jr Growth suppression in asthmatic children receiving prolonged therapy with prednisone and methylprednisolone. J Allergy. 1959 Mar-Apr;30(2):103–113. doi: 10.1016/0021-8707(59)90079-6. [DOI] [PubMed] [Google Scholar]
  36. Vortkamp A., Lee K., Lanske B., Segre G. V., Kronenberg H. M., Tabin C. J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 1996 Aug 2;273(5275):613–622. doi: 10.1126/science.273.5275.613. [DOI] [PubMed] [Google Scholar]
  37. Williams G. R., Robson H., Shalet S. M. Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol. 1998 Jun;157(3):391–403. doi: 10.1677/joe.0.1570391. [DOI] [PubMed] [Google Scholar]
  38. van der Veen M. J., Scheven B. A., van Roy J. L., Damen C. A., Lafeber F. P., Bijlsma J. W. In vitro effects of methotrexate on human articular cartilage and bone-derived osteoblasts. Br J Rheumatol. 1996 Apr;35(4):342–349. doi: 10.1093/rheumatology/35.4.342. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES