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. 2000 May;82(5):358–363. doi: 10.1136/adc.82.5.358

Prepubertal stature and blood pressure in early old age

S Montgomery 1, L Berney 1, D Blane 1
PMCID: PMC1718317  PMID: 10799423

Abstract

AIMS—To test the hypothesis that childhood growth rate is a marker for formation of control mechanisms that influence blood pressure in early old age.
METHODS—Data are from a sample of 149 (74 male) members of Sir John Boyd Orr's survey of British families conducted between 1937 and 1939. Measured heights were collected between ages 5 and 8 years, and in early old age between 1997 and 1998. Multiple linear regression investigated the relations of blood pressure with age and sex standardised childhood height with adjustment for potential confounding factors, including adult height. Inclusion of both childhood and adult heights in the same model was used to estimate growth, as measures of childhood height are relative to adult height.
RESULTS—Mean blood pressures in early old age for those in the shortest childhood height fifth were 167.8 and 76.3 mm Hg for systolic blood pressure and pulse pressure, respectively. For the tallest fifth they were 150.8 and 63.7 mm Hg, respectively. After adjustment for potential confounding factors including adult height, the mean increase for the shortest childhood height fifth compared with the tallest was 28.5 mm Hg for systolic pressure (p = 0.015) and 22.8 mm Hg (p = 0.010) for pulse pressure. The relations of blood pressure with adult height were not statistically significant in the adjusted models.
CONCLUSION—Prepubertal growth rate is associated with the formation of mechanisms associated with the control of blood pressure in later life.



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Selected References

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  1. Alterman T., Shekelle R. B., Vernon S. W., Burau K. D. Decision latitude, psychologic demand, job strain, and coronary heart disease in the Western Electric Study. Am J Epidemiol. 1994 Mar 15;139(6):620–627. doi: 10.1093/oxfordjournals.aje.a117051. [DOI] [PubMed] [Google Scholar]
  2. Berney L. R., Blane D. B. Collecting retrospective data: accuracy of recall after 50 years judged against historical records. Soc Sci Med. 1997 Nov;45(10):1519–1525. doi: 10.1016/s0277-9536(97)00088-9. [DOI] [PubMed] [Google Scholar]
  3. Blane D., Berney L., Smith G. D., Gunnell D. J., Holland P. Reconstructing the life course: health during early old age in a follow-up study based on the Boyd Orr cohort. Public Health. 1999 May;113(3):117–124. doi: 10.1016/s0033-3506(99)00135-3. [DOI] [PubMed] [Google Scholar]
  4. Bosma H., Marmot M. G., Hemingway H., Nicholson A. C., Brunner E., Stansfeld S. A. Low job control and risk of coronary heart disease in Whitehall II (prospective cohort) study. BMJ. 1997 Feb 22;314(7080):558–565. doi: 10.1136/bmj.314.7080.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gitau R., Cameron A., Fisk N. M., Glover V. Fetal exposure to maternal cortisol. Lancet. 1998 Aug 29;352(9129):707–708. doi: 10.1016/S0140-6736(05)60824-0. [DOI] [PubMed] [Google Scholar]
  6. Greco L., Power C., Peckham C. Adult outcome of normal children who are short or underweight at age 7 years. BMJ. 1995 Mar 18;310(6981):696–700. doi: 10.1136/bmj.310.6981.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gunnell D. J., Davey Smith G., Frankel S., Nanchahal K., Braddon F. E., Pemberton J., Peters T. J. Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war Britain. J Epidemiol Community Health. 1998 Mar;52(3):142–152. doi: 10.1136/jech.52.3.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gunnell D. J., Frankel S., Nanchahal K., Braddon F. E., Smith G. D. Lifecourse exposure and later disease: a follow-up study based on a survey of family diet and health in pre-war Britain (1937-1939). Public Health. 1996 Mar;110(2):85–94. doi: 10.1016/s0033-3506(96)80052-7. [DOI] [PubMed] [Google Scholar]
  9. Hallqvist J., Diderichsen F., Theorell T., Reuterwall C., Ahlbom A. Is the effect of job strain on myocardial infarction risk due to interaction between high psychological demands and low decision latitude? Results from Stockholm Heart Epidemiology Program (SHEEP). Soc Sci Med. 1998 Jun;46(11):1405–1415. doi: 10.1016/s0277-9536(97)10084-3. [DOI] [PubMed] [Google Scholar]
  10. Lever A. F., Harrap S. B. Essential hypertension: a disorder of growth with origins in childhood? J Hypertens. 1992 Feb;10(2):101–120. doi: 10.1097/00004872-199202000-00001. [DOI] [PubMed] [Google Scholar]
  11. Liu D., Diorio J., Tannenbaum B., Caldji C., Francis D., Freedman A., Sharma S., Pearson D., Plotsky P. M., Meaney M. J. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997 Sep 12;277(5332):1659–1662. doi: 10.1126/science.277.5332.1659. [DOI] [PubMed] [Google Scholar]
  12. Montgomery S. M., Bartley M. J., Cook D. G., Wadsworth M. E. Health and social precursors of unemployment in young men in Great Britain. J Epidemiol Community Health. 1996 Aug;50(4):415–422. doi: 10.1136/jech.50.4.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Montgomery S. M., Bartley M. J., Wilkinson R. G. Family conflict and slow growth. Arch Dis Child. 1997 Oct;77(4):326–330. doi: 10.1136/adc.77.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Nilsson P. M., Ostergren P. O., Nyberg P., Söderström M., Allebeck P. Low birth weight is associated with elevated systolic blood pressure in adolescence: a prospective study of a birth cohort of 149378 Swedish boys. J Hypertens. 1997 Dec;15(12 Pt 2):1627–1631. doi: 10.1097/00004872-199715120-00064. [DOI] [PubMed] [Google Scholar]
  15. Phillips D. I., Barker D. J., Fall C. H., Seckl J. R., Whorwood C. B., Wood P. J., Walker B. R. Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome? J Clin Endocrinol Metab. 1998 Mar;83(3):757–760. doi: 10.1210/jcem.83.3.4634. [DOI] [PubMed] [Google Scholar]
  16. Pickering T. G., Devereux R. B., James G. D., Gerin W., Landsbergis P., Schnall P. L., Schwartz J. E. Environmental influences on blood pressure and the role of job strain. J Hypertens Suppl. 1996 Dec;14(5):S179–S185. [PubMed] [Google Scholar]
  17. Pickering T. The effects of occupational stress on blood pressure in men and women. Acta Physiol Scand Suppl. 1997;640:125–128. [PubMed] [Google Scholar]
  18. Sapolsky R. M. The importance of a well-groomed child. Science. 1997 Sep 12;277(5332):1620–1621. doi: 10.1126/science.277.5332.1620. [DOI] [PubMed] [Google Scholar]
  19. Smulyan H., Marchais S. J., Pannier B., Guerin A. P., Safar M. E., London G. M. Influence of body height on pulsatile arterial hemodynamic data. J Am Coll Cardiol. 1998 Apr;31(5):1103–1109. doi: 10.1016/s0735-1097(98)00056-4. [DOI] [PubMed] [Google Scholar]
  20. Steptoe A., Cropley M., Joekes K. Job strain, blood pressure and response to uncontrollable stress. J Hypertens. 1999 Feb;17(2):193–200. doi: 10.1097/00004872-199917020-00003. [DOI] [PubMed] [Google Scholar]
  21. WIDDOWSON E. M. Mental contentment and physical growth. Lancet. 1951 Jun 16;1(6668):1316–1318. doi: 10.1016/s0140-6736(51)91795-3. [DOI] [PubMed] [Google Scholar]
  22. Whincup P. H., Cook D. G., Adshead F., Taylor S., Papacosta O., Walker M., Wilson V. Cardiovascular risk factors in British children from towns with widely differing adult cardiovascular mortality. BMJ. 1996 Jul 13;313(7049):79–84. doi: 10.1136/bmj.313.7049.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. de Simone G., Roman M. J., Daniels S. R., Mureddu G., Kimball T. R., Greco R., Devereux R. B. Age-related changes in total arterial capacitance from birth to maturity in a normotensive population. Hypertension. 1997 Jun;29(6):1213–1217. doi: 10.1161/01.hyp.29.6.1213. [DOI] [PubMed] [Google Scholar]

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