Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 2000 Oct;83(4):353–355. doi: 10.1136/adc.83.4.353

Recurrent skin peeling following Kawasaki disease

C Michie 1, V Kinsler 1, R Tulloh 1, S Davidson 1
PMCID: PMC1718513  PMID: 10999876

Abstract

Long term follow up of 259 cases of Kawasaki disease led to the observation that 11% of children have episodes of recurrent peeling of the skin for several years after their recovery. These events were usually associated with an upper respiratory tract infection and were distinct from a recurrence of Kawasaki disease. Repeeling was significantly less frequent in children who had suffered coronary artery dilatation and was more frequently seen in those with nasal staphylococcal colonisation. The mechanism for this phenomenon is unclear, but it has been observed in a number of other conditions caused by infectious agents and their toxins. Paediatricians need to be aware of this phenomenon which is distinct from recurrence of Kawasaki disease.



Full Text

The Full Text of this article is available as a PDF (98.9 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cherry J. D. 'Pertussis vaccine encephalopathy': it is time to recognize it as the myth that it is. JAMA. 1990 Mar 23;263(12):1679–1680. [PubMed] [Google Scholar]
  2. Classen J. B., Classen D. C. Association between type 1 diabetes and hib vaccine. Causal relation is likely. BMJ. 1999 Oct 23;319(7217):1133–1133. [PMC free article] [PubMed] [Google Scholar]
  3. Hall A., Kane M., Roure C., Meheus A. Multiple sclerosis and hepatitis B vaccine? Vaccine. 1999 Jun 4;17(20-21):2473–2475. doi: 10.1016/s0264-410x(99)00066-3. [DOI] [PubMed] [Google Scholar]
  4. Herroelen L., de Keyser J., Ebinger G. Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine. Lancet. 1991 Nov 9;338(8776):1174–1175. doi: 10.1016/0140-6736(91)92034-y. [DOI] [PubMed] [Google Scholar]
  5. Karvonen M., Cepaitis Z., Tuomilehto J. Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study. BMJ. 1999 May 1;318(7192):1169–1172. doi: 10.1136/bmj.318.7192.1169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Leung D. Y., Meissner H. C., Fulton D. R., Murray D. L., Kotzin B. L., Schlievert P. M. Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome. Lancet. 1993 Dec 4;342(8884):1385–1388. doi: 10.1016/0140-6736(93)92752-f. [DOI] [PubMed] [Google Scholar]
  7. Manders S. M., Heymann W. R., Atillasoy E., Kleeman J., Schlievert P. M. Recurrent toxin-mediated perineal erythema. Arch Dermatol. 1996 Jan;132(1):57–60. [PubMed] [Google Scholar]
  8. Michie C. A., Cohen J. The clinical significance of T-cell superantigens. Trends Microbiol. 1998 Feb;6(2):61–65. doi: 10.1016/S0966-842X(97)01193-1. [DOI] [PubMed] [Google Scholar]
  9. Nakamura Y., Oki I., Tanihara S., Ojima T., Yanagawa H. Cardiac sequelae in recurrent cases of Kawasaki disease: a comparison between the initial episode of the disease and a recurrence in the same patients. Pediatrics. 1998 Dec;102(6):E66–E66. doi: 10.1542/peds.102.6.e66. [DOI] [PubMed] [Google Scholar]
  10. Sundel R. P., Newburger J. W., McGill T., Cleveland S. S., Miller W. W., Berry B., Klein A. M., Burns J. C. Sensorineural hearing loss associated with Kawasaki disease. J Pediatr. 1990 Sep;117(3):371–377. doi: 10.1016/s0022-3476(05)81075-3. [DOI] [PubMed] [Google Scholar]
  11. Taylor B., Miller E., Farrington C. P., Petropoulos M. C., Favot-Mayaud I., Li J., Waight P. A. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet. 1999 Jun 12;353(9169):2026–2029. doi: 10.1016/s0140-6736(99)01239-8. [DOI] [PubMed] [Google Scholar]
  12. Tizard E. J., Suzuki A., Levin M., Dillon M. J. Clinical aspects of 100 patients with Kawasaki disease. Arch Dis Child. 1991 Feb;66(2):185–188. doi: 10.1136/adc.66.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Viard I., Wehrli P., Bullani R., Schneider P., Holler N., Salomon D., Hunziker T., Saurat J. H., Tschopp J., French L. E. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science. 1998 Oct 16;282(5388):490–493. doi: 10.1126/science.282.5388.490. [DOI] [PubMed] [Google Scholar]
  14. Wakefield A. J., Murch S. H., Anthony A., Linnell J., Casson D. M., Malik M., Berelowitz M., Dhillon A. P., Thomson M. A., Harvey P. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 1998 Feb 28;351(9103):637–641. doi: 10.1016/s0140-6736(97)11096-0. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES