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. 1990 Aug;34(8):1515–1517. doi: 10.1128/aac.34.8.1515

Meropenem pharmacokinetics and penetration into an inflammatory exudate.

R Wise 1, M Logan 1, M Cooper 1, J P Ashby 1, J M Andrews 1
PMCID: PMC171864  PMID: 2221860

Abstract

The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem in plasma was 1.1 h, with the concentration in plasma declining from a mean of 23.6 micrograms/ml at 1 h to 0.7 micrograms/ml at 6 h. The inflammatory fluid penetration was rapid (time to maximum concentration of drug in serum, 0.75 h), and the penetration was 111%. The recovery of meropenem in urine at 24 h was 65.4% of the administered dose.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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