Abstract
The in vitro activity of trospectomycin against 97 clinical isolates of oral pigmented Bacteroides species was compared with the activities of five other antimicrobial agents. At 4 micrograms/ml, more than 90% of isolates were inhibited by trospectomycin. Overall, strains that produced beta-lactamase (n = 41) were more resistant to trospectomycin, penicillin G, cefoxitin, piperacillin, and tetracycline but not to clindamycin. In this study, trospectomycin had excellent in vitro activity against oral pigmented Bacteroides species.
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Selected References
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- Edson R. S., Rosenblatt J. E., Lee D. T., McVey E. A., 3rd Recent experience with antimicrobial susceptibility of anaerobic bacteria: increasing resistance to penicillin. Mayo Clin Proc. 1982 Dec;57(12):737–741. [PubMed] [Google Scholar]
- Gabay E. L., Sutter V. L., Finegold S. M. Rapid beta-lactamase testing in bacteroides. J Antimicrob Chemother. 1981 Nov;8(5):413–416. doi: 10.1093/jac/8.5.413. [DOI] [PubMed] [Google Scholar]
- Jacobus N. V., Tally F. P. Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species. Antimicrob Agents Chemother. 1988 Apr;32(4):584–586. doi: 10.1128/aac.32.4.584. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peeters M., Van Dyck E., Piot P. In vitro activities of the spectinomycin analog U-63366 and four quinolone derivatives against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1984 Oct;26(4):608–609. doi: 10.1128/aac.26.4.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanson-Le Pors M. J., Casin I. M., Thebault M. C., Arlet G., Perol Y. In vitro activities of U-63366, a spectinomycin analog; roxithromycin (RU 28965), a new macrolide antibiotic; and five quinolone derivatives against Haemophilus ducreyi. Antimicrob Agents Chemother. 1986 Sep;30(3):512–513. doi: 10.1128/aac.30.3.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zurenko G. E., Yagi B. H., Vavra J. J., Wentworth B. B. In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog. Antimicrob Agents Chemother. 1988 Feb;32(2):216–223. doi: 10.1128/aac.32.2.216. [DOI] [PMC free article] [PubMed] [Google Scholar]