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. 1990 Aug;34(8):1619–1621. doi: 10.1128/aac.34.8.1619

Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.

K R Smith 1, K M Lank 1, C G Cobbs 1, G A Cloud 1, W E Dismukes 1
PMCID: PMC171887  PMID: 2221875

Abstract

We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P less than 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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