Abstract
Aims: To assess maternal compliance with nutritional recommendations in an allergy preventive programme, and identify factors influencing compliance behaviour.
Methods: Randomised double-blind intervention study on the effect of infant formulas with reduced allergenicity in healthy, term newborns at risk of atopy. Maternal compliance with dietary recommendations concerning milk and solid food feeding was categorised.
Results: A total of 2252 newborns were randomised to one of four study formulas. The drop out rate during the first year of life was 13.5% (n = 304). The rates of high, medium, and low compliance to milk feeding during weeks 1–16 were 83.4%, 4.0%, and 7.5%; the corresponding rates to solid food feeding during weeks 1–24 were 60.0%, 12.1%, and 22.9%. In 5.1% of subjects no nutritional information was available. Low compliance was more frequent among non-German parents, parents with a low level of education, young mothers, smoking mothers, and those who weaned their infant before the age of 2 months.
Conclusions: Evaluation of allergy preventive programmes should take into account non-compliance for assessing the preventive effectiveness on study outcome.
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Selected References
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- Dietz V. J., Lewin M., Zell E., Rodewald L. Evaluation of failure to follow vaccination recommendations as a marker for failure to follow other health recommendations. Pediatr Infect Dis J. 1997 Dec;16(12):1157–1161. doi: 10.1097/00006454-199712000-00011. [DOI] [PubMed] [Google Scholar]
- Epstein L. H., Cluss P. A. A behavioral medicine perspective on adherence to long-term medical regimens. J Consult Clin Psychol. 1982 Dec;50(6):950–971. doi: 10.1037//0022-006x.50.6.950. [DOI] [PubMed] [Google Scholar]
- Halken S., Høst A., Hansen L. G., Osterballe O. Preventive effect of feeding high-risk infants a casein hydrolysate formula or an ultrafiltrated whey hydrolysate formula. A prospective, randomized, comparative clinical study. Pediatr Allergy Immunol. 1993 Nov;4(4):173–181. doi: 10.1111/j.1399-3038.1993.tb00088.x. [DOI] [PubMed] [Google Scholar]
- Hide D. W., Matthews S., Tariq S., Arshad S. H. Allergen avoidance in infancy and allergy at 4 years of age. Allergy. 1996 Feb;51(2):89–93. [PubMed] [Google Scholar]
- Morse W., Sims L. S., Guthrie H. A. Mothers' compliance with physicians' recommendations on infant feeding. J Am Diet Assoc. 1979 Aug;75(2):140–147. [PubMed] [Google Scholar]
- Pöysä L., Remes K., Korppi M., Launiala K. Compliance with a dietary manipulation programme in families with infants prone to atopy. Acta Paediatr Scand. 1988 Jul;77(4):563–568. doi: 10.1111/j.1651-2227.1988.tb10701.x. [DOI] [PubMed] [Google Scholar]
- Savage S. A., Reilly J. J., Edwards C. A., Durnin J. V. Weaning practice in the Glasgow Longitudinal Infant Growth Study. Arch Dis Child. 1998 Aug;79(2):153–156. doi: 10.1136/adc.79.2.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shepherd C. K., Power K. G., Carter H. Characteristics of responders and non-responders in an infant feeding study. J Public Health Med. 1998 Sep;20(3):275–280. doi: 10.1093/oxfordjournals.pubmed.a024769. [DOI] [PubMed] [Google Scholar]
- Zeiger R. S. Prevention of food allergy and atopic disease. J R Soc Med. 1997;90 (Suppl 30):21–33. doi: 10.1177/0141076897090030s05. [DOI] [PMC free article] [PubMed] [Google Scholar]