Abstract
The in vitro activity of faeriefungin, a new pentaene macrolide lactone antibiotic produced by Streptomyces griseus var. autotrophicus, against 263 clinical bacterial isolates was examined. In contrast to the related fungicidal antibiotics nystatin and amphotericin B, which show no activity against bacteria, faeriefungin showed bactericidal activity against all species of gram-positive bacteria examined. MICs for these species ranged from 8 to 64 micrograms/ml, and the MIC for 90% of the isolates tested was 32 micrograms/ml. Isolates of some fastidious gram-negative species, including Neisseria gonorrhoeae, N. meningitidis, and Haemophilus influenzae, were slightly susceptible to faeriefungin, with MICs ranging from 16 to 128 micrograms/ml, but all members of the families Enterobacteriaceae and Pseudomonadaceae, with the exception of Pseudomonas cepacia, were completely resistant to faeriefungin at the concentrations tested. Faeriefungin is also active against fungi, nematodes, and mosquito larvae. The mode of action of faeriefungin against both bacteria and fungi is under investigation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURKE R. C., SWARTZ J. H., CHAPMAN S. S., HUANG W. Y. Mycoticin, a new antifungal antibiotic. J Invest Dermatol. 1954 Sep;23(3):163–168. doi: 10.1038/jid.1954.95. [DOI] [PubMed] [Google Scholar]
- Bognár R., Zsupán K., Makleit S., Brown B. O., Lockley W. J., Toube T. P., Weedon B. C. Flavofungin: a mixture of 13,15,17,19,21,23,25,27-octahydroxy-31-isopropyl-14-methyl- and 13,15,17,19,21,23,25,27-octahydroxy-14-methyl-31-s-butyl-hentriaconta-2,4,6,8,10,28-hexaen-31-olide. J Chem Soc Perkin 1. 1972;14:1848–1856. doi: 10.1039/p19720001848. [DOI] [PubMed] [Google Scholar]
- Chong C. N., Rickards R. W. Macrolide antibiotic studies. XVI. The structure of nystatin. Tetrahedron Lett. 1970 Dec;(59):5145–5148. doi: 10.1016/s0040-4039(00)96962-4. [DOI] [PubMed] [Google Scholar]
- Knapp J. S., Holmes K. K. Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements. J Infect Dis. 1975 Aug;132(2):204–208. doi: 10.1093/infdis/132.2.204. [DOI] [PubMed] [Google Scholar]
- Mishra S. K., Gordon R. E., Barnett D. A. Identification of nocardiae and streptomycetes of medical importance. J Clin Microbiol. 1980 Jun;11(6):728–736. doi: 10.1128/jcm.11.6.728-736.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nair M. G., Putnam A. R., Mishra S. K., Mulks M. H., Taft W. H., Keller J. E., Miller J. R., Zhu P. P., Meinhart J. D., Lynn D. G. Faeriefungin: a new broad-spectrum antibiotic from Streptomyces griseus var. autotrophicus. J Nat Prod. 1989 Jul-Aug;52(4):797–809. doi: 10.1021/np50064a022. [DOI] [PubMed] [Google Scholar]
- Pearson R. D., Steigbigel R. T., Davis H. T., Chapman S. W. Method of reliable determination of minimal lethal antibiotic concentrations. Antimicrob Agents Chemother. 1980 Nov;18(5):699–708. doi: 10.1128/aac.18.5.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor P. C., Schoenknecht F. D., Sherris J. C., Linner E. C. Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors. Antimicrob Agents Chemother. 1983 Jan;23(1):142–150. doi: 10.1128/aac.23.1.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
- URI J., BEKESI I. Flavofungin, a new crystalline antifungal antibiotic: origin and biological properties. Nature. 1958 Mar 29;181(4613):908–908. doi: 10.1038/181908a0. [DOI] [PubMed] [Google Scholar]
- Wasserman H. H., Van Verth J. E., McCaustland D. J., Borowitz I. J., Kamber B. The mycoticins, polyene macrolides from Streptomyces ruber. J Am Chem Soc. 1967 Mar 15;89(6):1535–1536. doi: 10.1021/ja00982a052. [DOI] [PubMed] [Google Scholar]