Abstract
Eighty-eight female patients with a history of recurrent urinary tract infections were treated according to a randomization scheme with either 1 g of cephradine every 12 h (47 patients) or 375 mg of amoxicillin-clavulanate every 8 h (41 patients) for 7 days. The treatments were equally effective (cure rates of 89% for cephradine and 88% for amoxicillin-clavulanate) and showed similar relapse rates (cephradine, 14%; amoxicillin-clavulanate, 11%). Adverse effects were similar in both groups (cephradine, 23%; amoxicillin-clavulanate, 22%).
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Selected References
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- Brumfitt W., Franklin I., Grady D., Hamilton-Miller J. M. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment. Antimicrob Agents Chemother. 1986 Aug;30(2):335–337. doi: 10.1128/aac.30.2.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M. Pivmecillinam in complicated urinary infections failing to respond to conventional therapy. Infection. 1982;10(3):149–152. doi: 10.1007/BF01640765. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Smith G. W., Hamilton-Miller J. M., Bax R. Successful use of reduced dosage of cinoxacin in the treatment of recurrent urinary infection. J Antimicrob Chemother. 1985 Dec;16(6):781–788. doi: 10.1093/jac/16.6.781. [DOI] [PubMed] [Google Scholar]
- Gurwith M. J., Stein G. E., Gurwith D. Prospective comparison of amoxicillin-clavulanic acid and cefaclor in treatment of uncomplicated urinary tract infections. Antimicrob Agents Chemother. 1983 Nov;24(5):716–719. doi: 10.1128/aac.24.5.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iravani A., Richard G. A. Single-dose cefuroxime axetil versus multiple-dose cefaclor in the treatment of acute urinary tract infections. Antimicrob Agents Chemother. 1989 Aug;33(8):1212–1216. doi: 10.1128/aac.33.8.1212. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iravani A., Richard G. A. Treatment of urinary tract infections with a combination of amoxicillin and clavulanic acid. Antimicrob Agents Chemother. 1982 Oct;22(4):672–677. doi: 10.1128/aac.22.4.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whitworth J. A., Fairley K. F., McIvor M. M. Cephradine in recurrent urinary tract infection. Med J Aust. 1973 Oct 13;2(15):742–743. doi: 10.5694/j.1326-5377.1973.tb129749.x. [DOI] [PubMed] [Google Scholar]