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. 1990 Sep;34(9):1806–1808. doi: 10.1128/aac.34.9.1806

Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system.

P Silley 1, J W Griffiths 1, D Monsey 1, A M Harris 1
PMCID: PMC171932  PMID: 2285295

Abstract

GR69153 is a novel cephalosporin incorporating a catechol-substituted 7-aminothiazolyl-oxime. The antibiotic is actively transported into gram-negative cells via iron-regulated outer membrane proteins regulated by the tonB product. This transport enhances bactericidal activity most significantly at low concentrations, essentially removing the permeability barrier for antibiotic uptake.

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Selected References

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