Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1990 Sep;34(9):1830–1832. doi: 10.1128/aac.34.9.1830

In vitro activities of ampicillin-sulbactam and cefoperazone-sulbactam against oxacillin-susceptible and oxacillin-resistant staphylococci.

A L Barry 1, R N Jones 1
PMCID: PMC171941  PMID: 2285302

Abstract

Ampicillin-sulbactam and cefoperazone-sulbactam were tested against staphylococci that were collected from 40 different medical centers throughout the United States. Oxacillin-resistant strains were resistant to both drug combinations, but oxacillin-susceptible strains were uniformly susceptible. The latter included strains with borderline susceptibility to oxacillin and methicillin.

Full text

PDF
1830

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry A. L., Badal R. E. Reliability of the microdilution technic for detection of methicillin-resistant strains of staphylococcus aureus. Am J Clin Pathol. 1977 May;67(5):489–495. doi: 10.1093/ajcp/67.5.489. [DOI] [PubMed] [Google Scholar]
  2. Barry A. L., Jones R. N. Proposed changes in interpretive criteria and potency of ampicillin and ampicillin-sulbactam disks for susceptibility tests. J Clin Microbiol. 1988 Apr;26(4):750–754. doi: 10.1128/jcm.26.4.750-754.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bush K. Beta-lactamase inhibitors from laboratory to clinic. Clin Microbiol Rev. 1988 Jan;1(1):109–123. doi: 10.1128/cmr.1.1.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chambers H. F., Archer G., Matsuhashi M. Low-level methicillin resistance in strains of Staphylococcus aureus. Antimicrob Agents Chemother. 1989 Apr;33(4):424–428. doi: 10.1128/aac.33.4.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chambers H. F. Methicillin-resistant staphylococci. Clin Microbiol Rev. 1988 Apr;1(2):173–186. doi: 10.1128/cmr.1.2.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fontana R. Penicillin-binding proteins and the intrinsic resistance to beta-lactams in gram-positive cocci. J Antimicrob Chemother. 1985 Oct;16(4):412–416. doi: 10.1093/jac/16.4.412. [DOI] [PubMed] [Google Scholar]
  7. Hartman B. J., Tomasz A. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J Bacteriol. 1984 May;158(2):513–516. doi: 10.1128/jb.158.2.513-516.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jones R. N., Barry A. L., Gardiner R. V., Packer R. R. The prevalence of staphylococcal resistance to penicillinase-resistant penicillins. A retrospective and prospective national surveillance trial of isolates from 40 medical centers. Diagn Microbiol Infect Dis. 1989 Sep-Oct;12(5):385–394. doi: 10.1016/0732-8893(89)90108-9. [DOI] [PubMed] [Google Scholar]
  9. Jones R. N., Barry A. L. Optimal dilution susceptibility testing conditions, recommendations for MIC interpretation, and quality control guidelines for the ampicillin-sulbactam combination. J Clin Microbiol. 1987 Oct;25(10):1920–1925. doi: 10.1128/jcm.25.10.1920-1925.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jones R. N., Barry A. L., Packer R. R., Gregory W. W., Thornsberry C. In vitro antimicrobial spectrum, occurrence of synergy, and recommendations for dilution susceptibility testing concentrations of the cefoperazone-sulbactam combination. J Clin Microbiol. 1987 Sep;25(9):1725–1729. doi: 10.1128/jcm.25.9.1725-1729.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jones R. N., Barry A. L., Thornsberry C., Wilson H. W. The cefoperazone-sulbactam combination. In vitro qualities including beta-lactamase stability, antimicrobial activity, and interpretive criteria for disk diffusion tests. Am J Clin Pathol. 1985 Oct;84(4):496–504. doi: 10.1093/ajcp/84.4.496. [DOI] [PubMed] [Google Scholar]
  12. Massanari R. M., Pfaller M. A., Wakefield D. S., Hammons G. T., McNutt L. A., Woolson R. F., Helms C. M. Implications of acquired oxacillin resistance in the management and control of Staphylococcus aureus infections. J Infect Dis. 1988 Oct;158(4):702–709. doi: 10.1093/infdis/158.4.702. [DOI] [PubMed] [Google Scholar]
  13. McDougal L. K., Thornsberry C. The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins. J Clin Microbiol. 1986 May;23(5):832–839. doi: 10.1128/jcm.23.5.832-839.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rossi L., Tonin E., Cheng Y. R., Fontana R. Regulation of penicillin-binding protein activity: description of a methicillin-inducible penicillin-binding protein in Staphylococcus aureus. Antimicrob Agents Chemother. 1985 May;27(5):828–831. doi: 10.1128/aac.27.5.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sierra-Madero J. G., Knapp C., Karaffa C., Washington J. A. Role of beta-lactamase and different testing conditions in oxacillin-borderline-susceptible staphylococci. Antimicrob Agents Chemother. 1988 Dec;32(12):1754–1757. doi: 10.1128/aac.32.12.1754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Thauvin-Eliopoulos C., Rice L. B., Eliopoulos G. M., Moellering R. C., Jr Efficacy of oxacillin and ampicillin-sulbactam combination in experimental endocarditis caused by beta-lactamase-hyperproducing Staphylococcus aureus. Antimicrob Agents Chemother. 1990 May;34(5):728–732. doi: 10.1128/aac.34.5.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thornsberry C., McDougal L. K. Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. J Clin Microbiol. 1983 Nov;18(5):1084–1091. doi: 10.1128/jcm.18.5.1084-1091.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Washburn R. G., Durack D. T. Efficacy of ampicillin plus a beta-lactamase inhibitor (CP-45,899) in experimental endocarditis due to Staphylococcus aureus. J Infect Dis. 1981 Sep;144(3):237–243. doi: 10.1093/infdis/144.3.237. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES