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. 2003 Dec;88(12):1095–1100. doi: 10.1136/adc.88.12.1095

Sudden infant death syndrome: a critical review of approaches to research

P Goldwater 1
PMCID: PMC1719412  PMID: 14670779

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Selected References

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  1. Alm B., Norvenius S. G., Wennergren G., Skjaerven R., Øyen N., Milerad J., Wennborg M., Kjaerbeck J., Helweg-Larsen K., Irgens L. M. Changes in the epidemiology of sudden infant death syndrome in Sweden 1973-1996. Arch Dis Child. 2001 Jan;84(1):24–30. doi: 10.1136/adc.84.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beal S. M., Finch C. F. An overview of retrospective case-control studies investigating the relationship between prone sleeping position and SIDS. J Paediatr Child Health. 1991 Dec;27(6):334–339. doi: 10.1111/j.1440-1754.1991.tb00414.x. [DOI] [PubMed] [Google Scholar]
  3. Beckwith J. B. Intrathoracic petechial hemorrhages: a clue to the mechanism of death in sudden infant death syndrome? Ann N Y Acad Sci. 1988;533:37–47. doi: 10.1111/j.1749-6632.1988.tb37232.x. [DOI] [PubMed] [Google Scholar]
  4. Berry P. J. Intra-alveolar haemorrhage in sudden infant death syndrome: a cause for concern? J Clin Pathol. 1999 Aug;52(8):553–554. doi: 10.1136/jcp.52.8.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bettelheim K. A., Goldwater P. N., Dwyer B. W., Bourne A. J., Smith D. L. Toxigenic Escherichia coli associated with sudden infant death syndrome. Scand J Infect Dis. 1990;22(4):467–476. doi: 10.3109/00365549009027079. [DOI] [PubMed] [Google Scholar]
  6. Bettiol S. S., Radcliff F. J., Hunt A. L., Goldsmid J. M. Bacterial flora of Tasmanian SIDS infants with special reference to pathogenic strains of Escherichia coli. Epidemiol Infect. 1994 Apr;112(2):275–284. doi: 10.1017/s095026880005768x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bian Z., Brauner A., Li Y., Normark S. Expression of and cytokine activation by Escherichia coli curli fibers in human sepsis. J Infect Dis. 2000 Feb;181(2):602–612. doi: 10.1086/315233. [DOI] [PubMed] [Google Scholar]
  8. Bian Z., Yan Z. Q., Hansson G. K., Thorén P., Normark S. Activation of inducible nitric oxide synthase/nitric oxide by curli fibers leads to a fall in blood pressure during systemic Escherichia coli infection in mice. J Infect Dis. 2001 Jan 12;183(4):612–619. doi: 10.1086/318528. [DOI] [PubMed] [Google Scholar]
  9. Bian Z., Yan Z. Q., Hansson G. K., Thorén P., Normark S. Activation of inducible nitric oxide synthase/nitric oxide by curli fibers leads to a fall in blood pressure during systemic Escherichia coli infection in mice. J Infect Dis. 2001 Jan 12;183(4):612–619. doi: 10.1086/318528. [DOI] [PubMed] [Google Scholar]
  10. Blackwell C. C., Gordon A. E., James V. S., MacKenzie D. A. C., Mogensen-Buchanan M., El Ahmer O. R., Al Madani O. M., Törö K., Csukás Z., Sótonyi P. The role of bacterial toxins in sudden infant death syndrome (SIDS). Int J Med Microbiol. 2002 Feb;291(6-7):561–570. doi: 10.1078/1438-4221-00168. [DOI] [PubMed] [Google Scholar]
  11. Blackwell C. Caroline, Busuttil Anthony, Weir Donald M. Risk factors for cot death increase danger from infection. BMJ. 2003 Jan 25;326(7382):222–222. [PMC free article] [PubMed] [Google Scholar]
  12. COOKE R. T., WELCH R. G. A STUDY IN COT DEATH. Br Med J. 1964 Dec 19;2(5424):1549–1554. doi: 10.1136/bmj.2.5424.1549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Conover P. T., Abramowsky C., Beyer-Patterson P. Immunohistochemical diagnosis of disseminated intravascular coagulation in newborns. Pediatr Pathol. 1990;10(5):707–716. doi: 10.3109/15513819009064706. [DOI] [PubMed] [Google Scholar]
  14. Crawley B. A., Morris J. A., Drucker D. B., Barson A. J., Morris J., Knox W. F., Oppenheim B. A. Endotoxin in blood and tissue in the sudden infant death syndrome. FEMS Immunol Med Microbiol. 1999 Aug 1;25(1-2):131–135. doi: 10.1111/j.1574-695X.1999.tb01336.x. [DOI] [PubMed] [Google Scholar]
  15. Delmonte C., Capelozzi V. L. Morphologic determinants of asphyxia in lungs: a semiquantitative study in forensic autopsies. Am J Forensic Med Pathol. 2001 Jun;22(2):139–149. doi: 10.1097/00000433-200106000-00006. [DOI] [PubMed] [Google Scholar]
  16. Dimitriadou V., Mécheri S., Koutsilieris M., Fraser W., Al-Daccak R., Mourad W. Expression of functional major histocompatibility complex class II molecules on HMC-1 human mast cells. J Leukoc Biol. 1998 Dec;64(6):791–799. doi: 10.1002/jlb.64.6.791. [DOI] [PubMed] [Google Scholar]
  17. Drucker D. B., Aluyi H. S., Morris J. A., Telford D. R., Gibbs A. Lethal synergistic action of toxins of bacteria isolated from sudden infant death syndrome. J Clin Pathol. 1992 Sep;45(9):799–801. doi: 10.1136/jcp.45.9.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Edston E., Gidlund E., Wickman M., Ribbing H., Van Hage-Hamsten M. Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxia or artefact? Clin Exp Allergy. 1999 Dec;29(12):1648–1654. doi: 10.1046/j.1365-2222.1999.00679.x. [DOI] [PubMed] [Google Scholar]
  19. Galland B. C., Taylor B. J., Bolton D. P. G. Prone versus supine sleep position: a review of the physiological studies in SIDS research. J Paediatr Child Health. 2002 Aug;38(4):332–338. doi: 10.1046/j.1440-1754.2002.00002.x. [DOI] [PubMed] [Google Scholar]
  20. Gardner A. Urinary tract infection during pregnancy and sudden unexpected infant death. Lancet. 1985 Aug 31;2(8453):495–495. doi: 10.1016/s0140-6736(85)90419-2. [DOI] [PubMed] [Google Scholar]
  21. Gilbert R. E., Wigfield R. E., Fleming P. J., Berry P. J., Rudd P. T. Bottle feeding and the sudden infant death syndrome. BMJ. 1995 Jan 14;310(6972):88–90. doi: 10.1136/bmj.310.6972.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Goldwater P. N. SIDS: more facts and controversies. Med J Aust. 2001 Mar 19;174(6):302–304. doi: 10.5694/j.1326-5377.2001.tb143277.x. [DOI] [PubMed] [Google Scholar]
  23. Goldwater P. N., Williams V., Bourne A. J., Byard R. W. Sudden infant death syndrome: a possible clue to causation. Med J Aust. 1990 Jul 2;153(1):59–60. doi: 10.5694/j.1326-5377.1990.tb125473.x. [DOI] [PubMed] [Google Scholar]
  24. Goldwater Paul N., Bettelheim Karl A. Curliated Escherichia coli, soluble curlin and the sudden infant death syndrome (SIDS). J Med Microbiol. 2002 Nov;51(11):1009–1012. doi: 10.1099/0022-1317-51-11-1009. [DOI] [PubMed] [Google Scholar]
  25. Grether J. K., Nelson K. B. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA. 1997 Jul 16;278(3):207–211. [PubMed] [Google Scholar]
  26. HANDFORTH C. P. Sudden unexpected death in infants. Can Med Assoc J. 1959 Jun 1;80(11):872–873. [PMC free article] [PubMed] [Google Scholar]
  27. Haas J. E., Taylor J. A., Bergman A. B., van Belle G., Felgenhauer J. L., Siebert J. R., Benjamin D. R. Relationship between epidemiologic risk factors and clinicopathologic findings in the sudden infant death syndrome. Pediatrics. 1993 Jan;91(1):106–112. [PubMed] [Google Scholar]
  28. Hamacher Jürg, Lucas Rudolf, Lijnen H. Roger, Buschke Susanne, Dunant Yves, Wendel Albrecht, Grau Georges E., Suter Peter M., Ricou Bara. Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002 Sep 1;166(5):651–656. doi: 10.1164/rccm.2109004. [DOI] [PubMed] [Google Scholar]
  29. Harrison L. M., Morris J. A., Telford D. R., Brown S. M., Jones K. The nasopharyngeal bacterial flora in infancy: effects of age, gender, season, viral upper respiratory tract infection and sleeping position. FEMS Immunol Med Microbiol. 1999 Aug 1;25(1-2):19–28. doi: 10.1111/j.1574-695X.1999.tb01323.x. [DOI] [PubMed] [Google Scholar]
  30. Herwald H., Mörgelin M., Olsén A., Rhen M., Dahlbäck B., Müller-Esterl W., Björck L. Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases. Nat Med. 1998 Mar;4(3):298–302. doi: 10.1038/nm0398-298. [DOI] [PubMed] [Google Scholar]
  31. Hoffman H. J., Damus K., Hillman L., Krongrad E. Risk factors for SIDS. Results of the National Institute of Child Health and Human Development SIDS Cooperative Epidemiological Study. Ann N Y Acad Sci. 1988;533:13–30. doi: 10.1111/j.1749-6632.1988.tb37230.x. [DOI] [PubMed] [Google Scholar]
  32. Hoffman H. J., Hillman L. S. Epidemiology of the sudden infant death syndrome: maternal, neonatal, and postneonatal risk factors. Clin Perinatol. 1992 Dec;19(4):717–737. [PubMed] [Google Scholar]
  33. JACOBSEN T., VOIGT J. Sudden and unexpected infant death. II. Result of medico-legal autopsies of 356 infants aged 0-2 years. Acta Med Leg Soc (Liege) 1956;9(Spec No):133–159. [PubMed] [Google Scholar]
  34. Jakeman K. J., Rushton D. I., Smith H., Sweet C. Exacerbation of bacterial toxicity to infant ferrets by influenza virus: possible role in sudden infant death syndrome. J Infect Dis. 1991 Jan;163(1):35–40. doi: 10.1093/infdis/163.1.35. [DOI] [PubMed] [Google Scholar]
  35. Kelly D. H., Pathak A., Meny R. Sudden severe bradycardia in infancy. Pediatr Pulmonol. 1991;10(3):199–204. doi: 10.1002/ppul.1950100312. [DOI] [PubMed] [Google Scholar]
  36. Kinney H. C., Brody B. A., Finkelstein D. M., Vawter G. F., Mandell F., Gilles F. H. Delayed central nervous system myelination in the sudden infant death syndrome. J Neuropathol Exp Neurol. 1991 Jan;50(1):29–48. doi: 10.1097/00005072-199101000-00003. [DOI] [PubMed] [Google Scholar]
  37. Kollef M. H., Schuster D. P. The acute respiratory distress syndrome. N Engl J Med. 1995 Jan 5;332(1):27–37. doi: 10.1056/NEJM199501053320106. [DOI] [PubMed] [Google Scholar]
  38. Krous H. F., Jordan J. A necropsy study of distribution of petechiae in non-sudden infant death syndrome. Arch Pathol Lab Med. 1984 Jan;108(1):75–76. [PubMed] [Google Scholar]
  39. Krous H. F. Pathological considerations of sudden infant death syndrome. Pediatrician. 1988;15(4):231–239. [PubMed] [Google Scholar]
  40. Krous H. F. The microscopic distribution of intrathoracic petechiae in sudden infant death syndrome. Arch Pathol Lab Med. 1984 Jan;108(1):77–79. [PubMed] [Google Scholar]
  41. Mitchell E. A. SIDS: facts and controversies. Med J Aust. 2000 Aug 21;173(4):175–176. doi: 10.5694/j.1326-5377.2000.tb125594.x. [DOI] [PubMed] [Google Scholar]
  42. Molony N., Blackwell C. C., Busuttil A. The effect of prone posture on nasal temperature in children in relation to induction of staphylococcal toxins implicated in sudden infant death syndrome. FEMS Immunol Med Microbiol. 1999 Aug 1;25(1-2):109–113. doi: 10.1111/j.1574-695X.1999.tb01333.x. [DOI] [PubMed] [Google Scholar]
  43. Murrell W. G., Stewart B. J., O'Neill C., Siarakas S., Kariks S. Enterotoxigenic bacteria in the sudden infant death syndrome. J Med Microbiol. 1993 Aug;39(2):114–127. doi: 10.1099/00222615-39-2-114. [DOI] [PubMed] [Google Scholar]
  44. Nelson K. B., Grether J. K. Causes of cerebral palsy. Curr Opin Pediatr. 1999 Dec;11(6):487–491. doi: 10.1097/00008480-199912000-00002. [DOI] [PubMed] [Google Scholar]
  45. Olsén A., Jonsson A., Normark S. Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli. Nature. 1989 Apr 20;338(6217):652–655. doi: 10.1038/338652a0. [DOI] [PubMed] [Google Scholar]
  46. Pearce J. L., Luke R. K., Bettelheim K. A. Extraintestinal Escherichia coli isolations from SIDS cases and other cases of sudden death in Victoria, Australia. FEMS Immunol Med Microbiol. 1999 Aug 1;25(1-2):137–144. doi: 10.1111/j.1574-695X.1999.tb01337.x. [DOI] [PubMed] [Google Scholar]
  47. Platt M. W., Blair P. S., Fleming P. J., Smith I. J., Cole T. J., Leach C. E., Berry P. J., Golding J. A clinical comparison of SIDS and explained sudden infant deaths: how healthy and how normal? CESDI SUDI Research Group. Confidential Inquiry into Stillbirths and Deaths in Infancy study. Arch Dis Child. 2000 Feb;82(2):98–106. doi: 10.1136/adc.82.2.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Poets C. F., Meny R. G., Chobanian M. R., Bonofiglo R. E. Gasping and other cardiorespiratory patterns during sudden infant deaths. Pediatr Res. 1999 Mar;45(3):350–354. doi: 10.1203/00006450-199903000-00010. [DOI] [PubMed] [Google Scholar]
  49. Risse M., Weiler G. Differential diagnosis SIDS/non-SIDS on the basis of histological findings of petechial thymus hemorrhages. Forensic Sci Int. 1989 Sep;43(1):1–7. doi: 10.1016/0379-0738(89)90115-1. [DOI] [PubMed] [Google Scholar]
  50. Sarawar S. R., Blackman M. A., Doherty P. C. Superantigen shock in mice with an inapparent viral infection. J Infect Dis. 1994 Nov;170(5):1189–1194. doi: 10.1093/infdis/170.5.1189. [DOI] [PubMed] [Google Scholar]
  51. Sayers N. M., Drucker D. B. Animal models used to test the interactions between infectious agents and products of cigarette smoked implicated in sudden infant death syndrome. FEMS Immunol Med Microbiol. 1999 Aug 1;25(1-2):115–123. doi: 10.1111/j.1574-695X.1999.tb01334.x. [DOI] [PubMed] [Google Scholar]
  52. Sayers N. M., Drucker D. B., Hutchinson I. V., Barson A. J. Preliminary investigation of lethally toxic sera of sudden infant death syndrome victims and neutralisation by commercially available immunoglobulins and adult sera. FEMS Immunol Med Microbiol. 1999 Aug 1;25(1-2):193–198. doi: 10.1111/j.1574-695X.1999.tb01343.x. [DOI] [PubMed] [Google Scholar]
  53. Sayers N. M., Drucker D. B., Telford D. R., Morris J. A. Effects of nicotine on bacterial toxins associated with cot death. Arch Dis Child. 1995 Dec;73(6):549–551. doi: 10.1136/adc.73.6.549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Siebert J. R., Haas J. E. Organ weights in sudden infant death syndrome. Pediatr Pathol. 1994 Nov-Dec;14(6):973–985. doi: 10.3109/15513819409037694. [DOI] [PubMed] [Google Scholar]
  55. Standfast S. J., Jereb S., Janerich D. T. The epidemiology of sudden infant death in upstate New York: II: birth characteristics. Am J Public Health. 1980 Oct;70(10):1061–1067. doi: 10.2105/ajph.70.10.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Takashima S., Armstrong D., Becker L. E., Huber J. Cerebral white matter lesions in sudden infant death syndrome. Pediatrics. 1978 Aug;62(2):155–159. [PubMed] [Google Scholar]
  57. Tappin David, Brooke Hazel, Ecob Russell, Gibson Angus. Used infant mattresses and sudden infant death syndrome in Scotland: case-control study. BMJ. 2002 Nov 2;325(7371):1007–1007. doi: 10.1136/bmj.325.7371.1007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Valdes-Dapena M. The pathologist and the sudden infant death syndrome. Am J Pathol. 1982 Jan;106(1):118–131. [PMC free article] [PubMed] [Google Scholar]
  59. Valdés-Dapena M. A. Sudden infant death syndrome: a review of the medical literature 1974-1979. Pediatrics. 1980 Oct;66(4):597–614. [PubMed] [Google Scholar]
  60. WERNE J., GARROW I. Sudden apparently unexplained death during infancy. I. Pathologic findings in infants found dead. Am J Pathol. 1953 Jul-Aug;29(4):633–675. [PMC free article] [PubMed] [Google Scholar]
  61. Williams A. L. Sudden infant death syndrome. Aust N Z J Obstet Gynaecol. 1990 May;30(2):98–107. doi: 10.1111/j.1479-828x.1990.tb03235.x. [DOI] [PubMed] [Google Scholar]

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