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. 1990 Nov;34(11):2047–2049. doi: 10.1128/aac.34.11.2047

Comparative in vitro activities of amoxicillin-clavulanic acid, cefuroxime, cephalexin, and cephalothin against trimethoprim-resistant Escherichia coli isolated from stools of children attending day-care centers.

K V Singh 1, R R Reves 1, L K Pickering 1, B E Murray 1
PMCID: PMC171996  PMID: 2073095

Abstract

A high prevalence of fecal colonization with trimethoprim-resistant Escherichia coli was found in diapered children attending day-care centers in Houston, Tex. In the present study, 100 isolates of E. coli resistant to multiple antibiotics, including trimethoprim (100%), sulfisoxazole (100%), streptomycin (94%), and ampicillin (87%), were obtained over a 5-month period from stool samples of diapered children attending four day-care centers and tested for their susceptibilities to amoxicillin-clavulanic acid, cefuroxime, cephalexin, and cephalothin. The MICs for 50 and 90% of strains tested were 16 and 32 micrograms/ml, respectively, for amoxicillin-clavulanic acid, 4 and 16 micrograms/ml, respectively, for cefuroxime, 4 and 64 micrograms/ml, respectively, for cephalexin, and 32 and greater than 64 micrograms/ml, respectively, for cephalothin. Although all three oral beta-lactams tested were generally active at concentrations likely to be achieved in urine, cefuroxime and cephalexin were more potent and are thus more likely to be inhibitory at the concentrations needed for systemic infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cullmann W., Dick W., Stieglitz M., Opferkuch W. Comparable evaluation of orally active beta-lactam compounds in ampicillin-resistant gram-positive and gram-negative rods: role of beta-lactamases on resistance. Chemotherapy. 1988;34(3):202–215. doi: 10.1159/000238572. [DOI] [PubMed] [Google Scholar]
  2. Fuchs P. C., Jones R. N., Barry A. L., Thornsberry C., Ayers L. W., Gavan T. L., Gerlach E. H. In vitro evaluation of cefixime (FK027, FR17027, CL284635): spectrum against recent clinical isolates, comparative antimicrobial activity, beta-lactamase stability, and preliminary susceptibility testing criteria. Diagn Microbiol Infect Dis. 1986 Jul;5(2):151–162. doi: 10.1016/0732-8893(86)90117-3. [DOI] [PubMed] [Google Scholar]
  3. Goodman R. A., Osterholm M. T., Granoff D. M., Pickering L. K. Infectious diseases and child day care. Pediatrics. 1984 Jul;74(1):134–139. [PubMed] [Google Scholar]
  4. Kado C. I., Liu S. T. Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol. 1981 Mar;145(3):1365–1373. doi: 10.1128/jb.145.3.1365-1373.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Murray B. E. Problems and mechanisms of antimicrobial resistance. Infect Dis Clin North Am. 1989 Sep;3(3):423–439. [PubMed] [Google Scholar]
  6. Neu H. C., Fu K. P. Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity. Antimicrob Agents Chemother. 1978 Apr;13(4):657–664. doi: 10.1128/aac.13.4.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. O'Callaghan C. H., Sykes R. B., Griffiths A., Thornton J. E. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976 Mar;9(3):511–519. doi: 10.1128/aac.9.3.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pickering L. K., Woodward W. E. Diarrhea in day care centers. Pediatr Infect Dis. 1982 Jan-Feb;1(1):47–52. doi: 10.1097/00006454-198201000-00015. [DOI] [PubMed] [Google Scholar]
  9. Reves R. R., Fong M., Pickering L. K., Bartlett A., 3rd, Alvarez M., Murray B. E. Risk factors for fecal colonization with trimethoprim-resistant and multiresistant Escherichia coli among children in day-care centers in Houston, Texas. Antimicrob Agents Chemother. 1990 Jul;34(7):1429–1434. doi: 10.1128/aac.34.7.1429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reves R. R., Murray B. E., Pickering L. K., Prado D., Maddock M., Bartlett A. V., 3rd Children with trimethoprim- and ampicillin-resistant fecal Escherichia coli in day care centers. J Infect Dis. 1987 Nov;156(5):758–762. doi: 10.1093/infdis/156.5.758. [DOI] [PubMed] [Google Scholar]
  11. Rydberg J., Cederberg A. Intrafamilial spreading of Escherichia coli resistant to trimethoprim. Scand J Infect Dis. 1986;18(5):457–460. doi: 10.3109/00365548609032364. [DOI] [PubMed] [Google Scholar]
  12. Van Landuyt H. W., Pyckavet M. In vitro of cefotaxime against cephalothin-resistant clinical isolates. Antimicrob Agents Chemother. 1979 Jul;16(1):109–111. doi: 10.1128/aac.16.1.109. [DOI] [PMC free article] [PubMed] [Google Scholar]

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