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. 1990 Nov;34(11):2093–2096. doi: 10.1128/aac.34.11.2093

Beta-lactam-fosfomycin antagonism involving modification of penicillin-binding protein 3 in Pseudomonas aeruginosa.

J A Reguera 1, F Baquero 1, J Berenguer 1, M Martinez-Ferrer 1, J L Martinez 1
PMCID: PMC172005  PMID: 2127343

Abstract

Antagonism between fosfomycin and antipseudomonal penicillins, cefotaxime, and ceftriaxone was observed in Pseudomonas aeruginosa RYC212. Fosfomycin, a non-beta-lactam antibiotic that acts on bacterial cell wall synthesis, decreased the expression of penicillin-binding protein 3 and induced beta-lactamase. The antagonistic effect was reduced in the presence of high concentrations of the beta-lactamase inhibitor tazobactam or in fosfomycin-resistant mutants. We suggest that products resulting from fosfomycin cell wall damage could interact with a system that regulates penicillin-binding protein and beta-lactamase production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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