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. 2005 Jan;90(1):57–59. doi: 10.1136/adc.2003.048504

Attention deficit and hyperactivity disorder, methylphenidate, and epilepsy

M Tan, R Appleton
PMCID: PMC1720074  PMID: 15613514

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Selected References

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  1. Aldenkamp A. P., Alpherts W. C., Blennow G., Elmqvist D., Heijbel J., Nilsson H. L., Sandstedt P., Tonnby B., Wåhlander L., Wosse E. Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study. Neurology. 1993 Jan;43(1):41–50. doi: 10.1212/wnl.43.1_part_1.41. [DOI] [PubMed] [Google Scholar]
  2. Andersen K. V., Trojaborg W. Risiko for udvikling af epileptiske anfald hos børn med subkliniske "epileptogene" eeg-abnormiteter. Ugeskr Laeger. 1993 Apr 26;155(17):1285–1288. [PubMed] [Google Scholar]
  3. Austin J. K., Harezlak J., Dunn D. W., Huster G. A., Rose D. F., Ambrosius W. T. Behavior problems in children before first recognized seizures. Pediatrics. 2001 Jan;107(1):115–122. doi: 10.1542/peds.107.1.115. [DOI] [PubMed] [Google Scholar]
  4. Becker Katja, Sinzig Judith K., Holtmann Martin. Attention deficits and subclinical epileptiform discharges: are EEG diagnostics in ADHD optional or essential? Dev Med Child Neurol. 2004 Jun;46(6):431–432. doi: 10.1017/s0012162204230705. [DOI] [PubMed] [Google Scholar]
  5. Bourgeois B. F. Antiepileptic drugs, learning, and behavior in childhood epilepsy. Epilepsia. 1998 Sep;39(9):913–921. doi: 10.1111/j.1528-1157.1998.tb01440.x. [DOI] [PubMed] [Google Scholar]
  6. Clarke Adam R., Barry Robert J., Bond Dominique, McCarthy Rory, Selikowitz Mark. Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. Psychopharmacology (Berl) 2002 Sep 11;164(3):277–284. doi: 10.1007/s00213-002-1205-0. [DOI] [PubMed] [Google Scholar]
  7. Dunn David W., Austin Joan K., Harezlak Jaroslaw, Ambrosius Walter T. ADHD and epilepsy in childhood. Dev Med Child Neurol. 2003 Jan;45(1):50–54. [PubMed] [Google Scholar]
  8. Feldman H., Crumrine P., Handen B. L., Alvin R., Teodori J. Methylphenidate in children with seizures and attention-deficit disorder. Am J Dis Child. 1989 Sep;143(9):1081–1086. doi: 10.1001/archpedi.1989.02150210117030. [DOI] [PubMed] [Google Scholar]
  9. Gross-Tsur V., Manor O., van der Meere J., Joseph A., Shalev R. S. Epilepsy and attention deficit hyperactivity disorder: is methylphenidate safe and effective? J Pediatr. 1997 Apr;130(4):670–674. doi: 10.1016/s0022-3476(97)70258-0. [DOI] [PubMed] [Google Scholar]
  10. Gucuyener Kivilcim, Erdemoglu A. Kemal, Senol Selahattin, Serdaroglu Ayşe, Soysal Sebnem, Kockar A. Ilden. Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. J Child Neurol. 2003 Feb;18(2):109–112. doi: 10.1177/08830738030180020601. [DOI] [PubMed] [Google Scholar]
  11. Hemmer S. A., Pasternak J. F., Zecker S. G., Trommer B. L. Stimulant therapy and seizure risk in children with ADHD. Pediatr Neurol. 2001 Feb;24(2):99–102. doi: 10.1016/s0887-8994(00)00240-x. [DOI] [PubMed] [Google Scholar]
  12. Holtmann Martin, Becker Katja, Kentner-Figura Beate, Schmidt Martin H. Increased frequency of rolandic spikes in ADHD children. Epilepsia. 2003 Sep;44(9):1241–1244. doi: 10.1046/j.1528-1157.2003.13403.x. [DOI] [PubMed] [Google Scholar]
  13. Hughes John R., DeLeo Andrea J., Melyn Michelle A. The Electroencephalogram in Attention Deficit-Hyperactivity Disorder: Emphasis on Epileptiform Discharges. Epilepsy Behav. 2000 Aug;1(4):271–277. doi: 10.1006/ebeh.2000.0073. [DOI] [PubMed] [Google Scholar]
  14. Oostrom K. J., Schouten A., Kruitwagen C. L. J. J., Peters A. C. B., Jennekens-Schinkel A., Dutch Study of Epilepsy in Childhood (DuSECh) Attention deficits are not characteristic of schoolchildren with newly diagnosed idiopathic or cryptogenic epilepsy. Epilepsia. 2002 Mar;43(3):301–310. doi: 10.1046/j.1528-1157.2002.32301.x. [DOI] [PubMed] [Google Scholar]
  15. Piccirilli M., D'Alessandro P., Sciarma T., Cantoni C., Dioguardi M. S., Giuglietti M., Ibba A., Tiacci C. Attention problems in epilepsy: possible significance of the epileptogenic focus. Epilepsia. 1994 Sep-Oct;35(5):1091–1096. doi: 10.1111/j.1528-1157.1994.tb02560.x. [DOI] [PubMed] [Google Scholar]
  16. Richer Lawrence P., Shevell Michael I., Rosenblatt Bernard R. Epileptiform abnormalities in children with attention-deficit-hyperactivity disorder. Pediatr Neurol. 2002 Feb;26(2):125–129. doi: 10.1016/s0887-8994(01)00370-8. [DOI] [PubMed] [Google Scholar]
  17. Semrud-Clikeman M., Wical B. Components of attention in children with complex partial seizures with and without ADHD. Epilepsia. 1999 Feb;40(2):211–215. doi: 10.1111/j.1528-1157.1999.tb02077.x. [DOI] [PubMed] [Google Scholar]
  18. Stein M. A., Blondis T. A., Schnitzler E. R., O'Brien T., Fishkin J., Blackwell B., Szumowski E., Roizen N. J. Methylphenidate dosing: twice daily versus three times daily. Pediatrics. 1996 Oct;98(4 Pt 1):748–756. [PubMed] [Google Scholar]
  19. Sánchez-Carpintero Rocio, Neville Brian G. R. Attentional ability in children with epilepsy. Epilepsia. 2003 Oct;44(10):1340–1349. doi: 10.1046/j.1528-1157.2003.16403.x. [DOI] [PubMed] [Google Scholar]
  20. Weinberg W. A., Harper C. R., Schraufnagel C. D., Brumback R. A. Attention deficit hyperactivity disorder: a disease or a symptom complex? J Pediatr. 1997 Apr;130(4):665–669. doi: 10.1016/s0022-3476(97)70257-9. [DOI] [PubMed] [Google Scholar]
  21. Williams J., Bates S., Griebel M. L., Lange B., Mancias P., Pihoker C. M., Dykman R. Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes? Epilepsia. 1998 Oct;39(10):1064–1069. doi: 10.1111/j.1528-1157.1998.tb01291.x. [DOI] [PubMed] [Google Scholar]
  22. Williams J., Griebel M. L., Dykman R. A. Neuropsychological patterns in pediatric epilepsy. Seizure. 1998 Jun;7(3):223–228. doi: 10.1016/s1059-1311(98)80040-x. [DOI] [PubMed] [Google Scholar]
  23. Wroblewski B. A., Leary J. M., Phelan A. M., Whyte J., Manning K. Methylphenidate and seizure frequency in brain injured patients with seizure disorders. J Clin Psychiatry. 1992 Mar;53(3):86–89. [PubMed] [Google Scholar]

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