Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1990 Dec;34(12):2297–2299. doi: 10.1128/aac.34.12.2297

Increase in resistance of Mycoplasma hominis to tetracyclines.

M C Cummings 1, W M McCormack 1
PMCID: PMC172049  PMID: 2088184

Abstract

Isolates of Mycoplasma hominis collected from patients in Boston and New York between 1976 and 1989 were studied. Minimal metabolism-inhibiting concentrations (MMCs) were determined by use of a terminal color change-broth dilution method, as well as by an agar inoculum-broth dilution method. Both methods gave comparable results. Tetracycline MMCs for 3 (7.0%) of 43 isolates of M. hominis collected from 1976 to 1979 were 8 micrograms/ml or more, but they were 8 micrograms/ml or more for 11 (20.3%) of 54 isolates collected from 1980 to 1983 (P = 0.083) and 16 (26.6%) of 60 isolates collected from 1984 to 1989 (P = 0.019). Similarly, doxycycline MMCs for 0 of 43 isolates of M. hominis collected from 1976 to 1979 were 8 micrograms/ml or more, but they were 8 micrograms/ml or more for 8 (14.8%) of 54 strains isolated from 1980 to 1983 (P = 0.0082) and 10 (16.6%) of 60 strains isolated from 1984 to 1989 (P = 0.0047). The susceptibility of M. hominis to clindamycin did not change. We conclude that isolates of M. hominis in the northeastern United States have become more resistant to tetracycline and doxycycline over the past decade.

Full text

PDF
2297

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bygdeman S. M., Mårdh P. A. Antimicrobial susceptibility and susceptibility testing of Mycoplasma hominis: a review. Sex Transm Dis. 1983 Oct-Dec;10(4 Suppl):366–370. [PubMed] [Google Scholar]
  2. Christiansson A., Mårdh P. A. Tetracycline resistance in Mycoplasma hominis. Sex Transm Dis. 1983 Oct-Dec;10(4 Suppl):371–373. [PubMed] [Google Scholar]
  3. Christiansson A., Mårdh P. A. Tetracycline resistance in Mycoplasma hominis. Sex Transm Dis. 1983 Oct-Dec;10(4 Suppl):371–373. [PubMed] [Google Scholar]
  4. Hjelm E., Jonsell G., Linglöf T., Mårdh P. A., Møller B., Sedin G. Meningitis in a newborn infant caused by Mycoplasma hominis. Acta Paediatr Scand. 1980 May;69(3):415–418. doi: 10.1111/j.1651-2227.1980.tb07103.x. [DOI] [PubMed] [Google Scholar]
  5. Jagielski M. Wrazliwoś Mycoplasma hominis na wybrane antybiotyki. Med Dosw Mikrobiol. 1979;31(4):225–237. [PubMed] [Google Scholar]
  6. Kenny G. E., Hooton T. M., Roberts M. C., Cartwright F. D., Hoyt J. Susceptibilities of genital mycoplasmas to the newer quinolones as determined by the agar dilution method. Antimicrob Agents Chemother. 1989 Jan;33(1):103–107. doi: 10.1128/aac.33.1.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Koutsky L. A., Stamm W. E., Brunham R. C., Stevens C. E., Cole B., Hale J., Davick P., Holmes K. K. Persistence of Mycoplasma hominis after therapy: importance of tetracycline resistance and of coexisting vaginal flora. Sex Transm Dis. 1983 Oct-Dec;10(4 Suppl):374–381. [PubMed] [Google Scholar]
  8. McCormack W. M., Almeida P. C., Bailey P. E., Grady E. M., Lee Y. H. Sexual activity and vaginal colonization with genital mycoplasmas. JAMA. 1972 Sep 18;221(12):1375–1377. [PubMed] [Google Scholar]
  9. McCormack W. M., Lee Y. H., Zinner S. H. Sexual experience and urethral colonization with genital mycoplasmas. A study in normal men. Ann Intern Med. 1973 May;78(5):696–698. doi: 10.7326/0003-4819-78-5-696. [DOI] [PubMed] [Google Scholar]
  10. McCormack W. M., Rosner B., Alpert S., Evrard J. R., Crockett V. A., Zinner S. H. Vaginal colonization with mycoplasma hominis and ureaplasma urealyticum. Sex Transm Dis. 1986 Apr-Jun;13(2):67–70. doi: 10.1097/00007435-198604000-00002. [DOI] [PubMed] [Google Scholar]
  11. Mårdh P. A., Weström L. Tubal and cervical cultures in acute salpingitis with special reference to Mycoplasma hominis and T-strain mycoplasmas. Br J Vener Dis. 1970 Jun;46(3):179–186. [PMC free article] [PubMed] [Google Scholar]
  12. Roberts M. C., Koutsky L. A., Holmes K. K., LeBlanc D. J., Kenny G. E. Tetracycline-resistant Mycoplasma hominis strains contain streptococcal tetM sequences. Antimicrob Agents Chemother. 1985 Jul;28(1):141–143. doi: 10.1128/aac.28.1.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Taylor-Robinson D., McCormack W. M. The genital mycoplasmas (second of two parts). N Engl J Med. 1980 May 8;302(19):1063–1067. doi: 10.1056/NEJM198005083021905. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES