Abstract
Aims—To determine and compare two urinary indices of renal tubular function, N-acetyl-glucosaminidase (NAG) and β2-microglobulin (β2M), in healthy term neonates and babies with perinatal asphyxia. METHODS—In a prospective case-control study using asphyxiated (n=35) and normal control (n=55) infants, urinary NAG and β2M were assayed at 24-48 hours of life, 4-6 days, and 4-6 weeks. RESULTS—NAG and β2M were significantly increased at 24-48 hours and 4-6 days in the asphyxiated infants compared with the controls. Increased NAG values reflect the degree of perinatal asphyxia more than do β2M. Gentamicin also increased NAG excretion, but to a lesser extent than did perinatal asphyxia. CONCLUSIONS—NAG (+/- β2M) may be a useful marker of perinatal asphyxia. Urinary NAG concentrations correlate with the severity of perinatal asphyxia. Keywords: perinatal asphyxia; renal tubular function; N-acetyl-glucosaminidase
Full Text
The Full Text of this article is available as a PDF (117.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fernandez F., Barrio V., Guzman J., Huertas M. D., Zapatero M., de Miguel M. D., Mallol J. Beta-2-microglobulin in the assessment of renal function in full term newborns following perinatal asphyxia. J Perinat Med. 1989;17(6):453–459. doi: 10.1515/jpme.1989.17.6.453. [DOI] [PubMed] [Google Scholar]
- Karlowicz M. G., Adelman R. D. Nonoliguric and oliguric acute renal failure in asphyxiated term neonates. Pediatr Nephrol. 1995 Dec;9(6):718–722. doi: 10.1007/BF00868721. [DOI] [PubMed] [Google Scholar]
- Kojima T., Kobayashi T., Matsuzaki S., Iwase S., Kobayashi Y. Effects of perinatal asphyxia and myoglobinuria on development of acute, neonatal renal failure. Arch Dis Child. 1985 Oct;60(10):908–912. doi: 10.1136/adc.60.10.908. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mathew T. H. Drug-induced renal disease. Med J Aust. 1992 May 18;156(10):724–728. doi: 10.5694/j.1326-5377.1992.tb121517.x. [DOI] [PubMed] [Google Scholar]
- Mehta K. P. Neonatal renal failure. Indian Pediatr. 1991 Jan;28(1):7–9. [PubMed] [Google Scholar]
- Perlman J. M., Tack E. D., Martin T., Shackelford G., Amon E. Acute systemic organ injury in term infants after asphyxia. Am J Dis Child. 1989 May;143(5):617–620. doi: 10.1001/archpedi.1989.02150170119037. [DOI] [PubMed] [Google Scholar]
- Roberts D. S., Haycock G. B., Dalton R. N., Turner C., Tomlinson P., Stimmler L., Scopes J. W. Prediction of acute renal failure after birth asphyxia. Arch Dis Child. 1990 Oct;65(10 Spec No):1021–1028. doi: 10.1136/adc.65.10_spec_no.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sarnat H. B., Sarnat M. S. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976 Oct;33(10):696–705. doi: 10.1001/archneur.1976.00500100030012. [DOI] [PubMed] [Google Scholar]
- Tack E. D., Perlman J. M., Robson A. M. Renal injury in sick newborn infants: a prospective evaluation using urinary beta 2-microglobulin concentrations. Pediatrics. 1988 Mar;81(3):432–440. [PubMed] [Google Scholar]
- Tsukahara H., Yoshimoto M., Saito M., Sakaguchi T., Mitsuyoshi I., Hayashi S., Nakamura K., Kikuchi K., Sudo M. Assessment of tubular function in neonates using urinary beta 2-microglobulin. Pediatr Nephrol. 1990 Sep;4(5):512–514. doi: 10.1007/BF00869835. [DOI] [PubMed] [Google Scholar]
- Watanabe K., Kojima T., Fukuda Y., Ohbayashi K., Kobayashi T., Iwase S., Kobayashi Y. Reliability of urinary N-acetyl-beta-D-glucosaminidase as an indicator of renal tubular damage in neonates. Biol Neonate. 1987;52(1):16–21. doi: 10.1159/000242679. [DOI] [PubMed] [Google Scholar]