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. 1990 Dec;34(12):2417–2419. doi: 10.1128/aac.34.12.2417

Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds.

A Akesson-Johansson 1, J Harmenberg 1, B Wahren 1, A Linde 1
PMCID: PMC172072  PMID: 1965107

Abstract

The in vitro susceptibilities of human herpesvirus 6 to foscarnet; the guanosine analogs acyclovir, ganciclovir, and two isomers of 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine; and the thymidine analogs 3'-azido-3'-deoxythymidine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil were investigated. All compounds except 3'-azido-3'-deoxythymidine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil inhibited human herpesvirus 6 replication. The highest in vitro selectivity was obtained for 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abele G., Karlström A., Harmenberg J., Shigeta S., Larsson A., Lindborg B., Wahren B. Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture. Antimicrob Agents Chemother. 1987 Jan;31(1):76–80. doi: 10.1128/aac.31.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ablashi D. V., Josephs S. F., Buchbinder A., Hellman K., Nakamura S., Llana T., Lusso P., Kaplan M., Dahlberg J., Memon S. Human B-lymphotropic virus (human herpesvirus-6). J Virol Methods. 1988 Sep;21(1-4):29–48. doi: 10.1016/0166-0934(88)90050-x. [DOI] [PubMed] [Google Scholar]
  3. Agut H., Collandre H., Aubin J. T., Guétard D., Favier V., Ingrand D., Montagnier L., Huraux J. M. In vitro sensitivity of human herpesvirus-6 to antiviral drugs. Res Virol. 1989 May-Jun;140(3):219–228. doi: 10.1016/s0923-2516(89)80099-8. [DOI] [PubMed] [Google Scholar]
  4. Biberfeld P., Petrén A. L., Eklund A., Lindemalm C., Barkhem T., Ekman M., Ablashi D., Salahuddin Z. Human herpesvirus-6 (HHV-6, HBLV) in sarcoidosis and lymphoproliferative disorders. J Virol Methods. 1988 Sep;21(1-4):49–59. doi: 10.1016/0166-0934(88)90051-1. [DOI] [PubMed] [Google Scholar]
  5. Di Luca D., Katsafanas G., Schirmer E. C., Balachandran N., Frenkel N. The replication of viral and cellular DNA in human herpesvirus 6-infected cells. Virology. 1990 Mar;175(1):199–210. doi: 10.1016/0042-6822(90)90200-b. [DOI] [PubMed] [Google Scholar]
  6. Ensoli B., Lusso P., Schachter F., Josephs S. F., Rappaport J., Negro F., Gallo R. C., Wong-Staal F. Human herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancer. EMBO J. 1989 Oct;8(10):3019–3027. doi: 10.1002/j.1460-2075.1989.tb08452.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kikuta H., Lu H., Matsumoto S. Susceptibility of human herpesvirus 6 to acyclovir. Lancet. 1989 Oct 7;2(8667):861–861. doi: 10.1016/s0140-6736(89)93019-5. [DOI] [PubMed] [Google Scholar]
  8. Lawrence G. L., Chee M., Craxton M. A., Gompels U. A., Honess R. W., Barrell B. G. Human herpesvirus 6 is closely related to human cytomegalovirus. J Virol. 1990 Jan;64(1):287–299. doi: 10.1128/jvi.64.1.287-299.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Linde A., Dahl H., Wahren B., Fridell E., Salahuddin Z., Biberfeld P. IgG antibodies to human herpesvirus-6 in children and adults and in primary Epstein-Barr virus infections and cytomegalovirus infections [corrected]. J Virol Methods. 1988 Sep;21(1-4):117–123. doi: 10.1016/0166-0934(88)90058-4. [DOI] [PubMed] [Google Scholar]
  10. Oberg B. Antiviral effects of phosphonoformate (PFA, foscarnet sodium). Pharmacol Ther. 1989;40(2):213–285. doi: 10.1016/0163-7258(89)90097-1. [DOI] [PubMed] [Google Scholar]
  11. Pietroboni G. R., Harnett G. B., Farr T. J., Bucens M. R. Human herpes virus type 6 (HHV-6) and its in vitro effect on human immunodeficiency virus (HIV). J Clin Pathol. 1988 Dec;41(12):1310–1312. doi: 10.1136/jcp.41.12.1310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Russler S. K., Tapper M. A., Carrigan D. R. Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir. Lancet. 1989 Aug 12;2(8659):382–382. doi: 10.1016/s0140-6736(89)90555-2. [DOI] [PubMed] [Google Scholar]
  13. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. doi: 10.1126/science.2876520. [DOI] [PubMed] [Google Scholar]
  14. Shiraki K., Okuno T., Yamanishi K., Takahashi M. Phosphonoacetic acid inhibits replication of human herpesvirus-6. Antiviral Res. 1989 Dec;12(5-6):311–318. doi: 10.1016/0166-3542(89)90058-2. [DOI] [PubMed] [Google Scholar]
  15. Streicher H. Z., Hung C. L., Ablashi D. V., Hellman K., Saxinger C., Fullen J., Salahuddin S. Z. In vitro inhibition of human herpesvirus-6 by phosphonoformate. J Virol Methods. 1988 Sep;21(1-4):301–304. doi: 10.1016/0166-0934(88)90075-4. [DOI] [PubMed] [Google Scholar]
  16. Ward K. N., Gray J. J., Efstathiou S. Brief report: primary human herpesvirus 6 infection in a patient following liver transplantation from a seropositive donor. J Med Virol. 1989 Jun;28(2):69–72. doi: 10.1002/jmv.1890280203. [DOI] [PubMed] [Google Scholar]
  17. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988 May 14;1(8594):1065–1067. doi: 10.1016/s0140-6736(88)91893-4. [DOI] [PubMed] [Google Scholar]

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