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. 1988 Jan;32(1):9–14. doi: 10.1128/aac.32.1.9

Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors.

M D Kitzis 1, D Billot-Klein 1, F W Goldstein 1, R Williamson 1, G Tran Van Nhieu 1, J Carlet 1, J F Acar 1, L Gutmann 1
PMCID: PMC172088  PMID: 2831817

Abstract

The novel beta-lactamase CTX-1 (pI 6.3) encoded on a transferable 84-kilobase plasmid was found in six different bacterial species. It was responsible for a significant decrease in susceptibility towards most penicillins and cephalosporins, except imipenem, temocillin, and cephalosporins which have a 7-alpha-methoxy substituent. Synergy between either ampicillin, piperacillin, cefotaxime, ceftazidime, or aztreonam and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and YTR 830) was generally found for different strains harboring CTX-1. This enzyme may be related to or derived from the TEM enzyme, since an intragenic probe of the TEM-1 gene hybridized with a fragment of the plasmid carrying CTX-1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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