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Archives of Disease in Childhood. Fetal and Neonatal Edition logoLink to Archives of Disease in Childhood. Fetal and Neonatal Edition
. 1999 Jul;81(1):F69–F70. doi: 10.1136/fn.81.1.f69

Neonatal varicella: varicella zoster immunoglobulin (VZIG) does not prevent disease

L Reynolds, S Struik, S Nadel
PMCID: PMC1720945  PMID: 10375368

Abstract

Two infants with severe varicella are reported. They received varicella zoster immunoglobulin (VZIG) without concurrent information to parents or carers regarding further care. In both these cases there was a three day delay between the onset of symptoms and initiation of aciclovir. This delay was due to lack of awareness of the high risk of varicella in these infants.
 Infants born to mothers with onset of chickenpox 4 days before to 2 days after delivery are at risk of fatal varicella, despite the use of VZIG prophylaxis.



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Selected References

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