Abstract
AIMS—To document the reproductive choices made by women in New South Wales, Australia, after neonatal screening has identified cystic fibrosis (CF). METHODS—A sample of women attending cystic fibrosis clinics in New South Wales who had a child (or children) diagnosed by neonatal screening between 1981 and 1996 were interviewed. RESULTS—Two thirds of the women chose to avoid having another child with CF. The uptake of prenatal diagnosis was 66% in women who had a subsequent pregnancy; of these 69% terminated or would have terminated an affected fetus. Fifty nine per cent of the women who decided against a further pregnancy made this decision in order to avoid having another child with CF. CONCLUSIONS—These data show that having a child with CF influenced subsequent reproductive choices. In addition to the medical advantages of an early diagnosis offered by neonatal screening, this also allows informed future reproductive decisions.
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Selected References
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- Adam A. Y. Convergence on the two-child family norm in Australia. J Aust Popul Assoc. 1991 Nov;8(2):77–91. doi: 10.1007/BF03029438. [DOI] [PubMed] [Google Scholar]
- Cunningham S., Marshall T. Influence of five years of antenatal screening on the paediatric cystic fibrosis population in one region. Arch Dis Child. 1998 Apr;78(4):345–348. doi: 10.1136/adc.78.4.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evers-Kiebooms G., Denayer L., Van den Berghe H. A child with cystic fibrosis: II. Subsequent family planning decisions, reproduction and use of prenatal diagnosis. Clin Genet. 1990 Mar;37(3):207–215. doi: 10.1111/j.1399-0004.1990.tb03504.x. [DOI] [PubMed] [Google Scholar]
- Farrell P. M., Kosorok M. R., Laxova A., Shen G., Koscik R. E., Bruns W. T., Splaingard M., Mischler E. H. Nutritional benefits of neonatal screening for cystic fibrosis. Wisconsin Cystic Fibrosis Neonatal Screening Study Group. N Engl J Med. 1997 Oct 2;337(14):963–969. doi: 10.1056/NEJM199710023371403. [DOI] [PubMed] [Google Scholar]
- Mischler E. H., Wilfond B. S., Fost N., Laxova A., Reiser C., Sauer C. M., Makholm L. M., Shen G., Feenan L., McCarthy C. Cystic fibrosis newborn screening: impact on reproductive behavior and implications for genetic counseling. Pediatrics. 1998 Jul;102(1 Pt 1):44–52. doi: 10.1542/peds.102.1.44. [DOI] [PubMed] [Google Scholar]
- Watson E. K., Marchant J., Bush A., Williamson B. Attitudes towards prenatal diagnosis and carrier screening for cystic fibrosis among the parents of patients in a paediatric cystic fibrosis clinic. J Med Genet. 1992 Jul;29(7):490–491. [PMC free article] [PubMed] [Google Scholar]
- Wertz D. C., Janes S. R., Rosenfield J. M., Erbe R. W. Attitudes toward the prenatal diagnosis of cystic fibrosis: factors in decision making among affected families. Am J Hum Genet. 1992 May;50(5):1077–1085. [PMC free article] [PubMed] [Google Scholar]
- Wilcken B., Wiley V., Sherry G., Bayliss U. Neonatal screening for cystic fibrosis: a comparison of two strategies for case detection in 1.2 million babies. J Pediatr. 1995 Dec;127(6):965–970. doi: 10.1016/s0022-3476(95)70040-4. [DOI] [PubMed] [Google Scholar]