Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1988 Jan;32(1):141–143. doi: 10.1128/aac.32.1.141

LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci.

A S Bayer 1, J Yih 1, L Hirano 1
PMCID: PMC172116  PMID: 2831811

Abstract

Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously. Penicillin G and LY146032 reduced mean intravegetation group G streptococcal densities significantly below those observed in controls at both day 3 and day 6 of therapy. Penicillin G effected a more rapid clearance of intravegetation streptococci than LY146032 by day 3, but not by day 6, of therapy.

Full text

PDF
141

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Archer G., Fekety F. R. Experimental endocarditis due to Pseudomonas aeruginosa. I. Description of a model. J Infect Dis. 1976 Jul;134(1):1–7. doi: 10.1093/infdis/134.1.1. [DOI] [PubMed] [Google Scholar]
  2. Auckenthaler R., Hermans P. E., Washington J. A., 2nd Group G streptococcal bacteremia: clinical study and review of the literature. Rev Infect Dis. 1983 Mar-Apr;5(2):196–204. doi: 10.1093/clinids/5.2.196. [DOI] [PubMed] [Google Scholar]
  3. Carrizosa J., Kaye D. Antibiotic synergism in enterococcal endocarditis. J Lab Clin Med. 1976 Jul;88(1):132–141. [PubMed] [Google Scholar]
  4. Choi C., Bayer A. S., Fujita N. K., Lam K., Guze L. B., Yoshikawa T. T. Therapy of experimental Pseudomonas endocarditis with high-dose amikacin and ticarcillin. Chemotherapy. 1983;29(4):303–312. doi: 10.1159/000238213. [DOI] [PubMed] [Google Scholar]
  5. Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
  6. Fass R. J., Helsel V. L. In vitro activity of LY146032 against staphylococci, streptococci, and enterococci. Antimicrob Agents Chemother. 1986 Nov;30(5):781–784. doi: 10.1128/aac.30.5.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fujita N. K., Lam K., Bayer A. S. Septic arthritis due to group G streptococcus. JAMA. 1982 Feb 12;247(6):812–813. [PubMed] [Google Scholar]
  8. Lam K., Bayer A. S. Serious infections due to group G streptoccocci. Report of 15 cases with in vitro-in vivo correlations. Am J Med. 1983 Oct;75(4):561–570. doi: 10.1016/0002-9343(83)90434-5. [DOI] [PubMed] [Google Scholar]
  9. Nakata M. M., Silvers J. H., George W. L. Group G streptococcal arthritis. Arch Intern Med. 1983 Jul;143(7):1328–1330. [PubMed] [Google Scholar]
  10. Prober C. G., Dougherty S. S., Vosti K. L., Yeager A. S. Comparison of a micromethod for performance of the serum bactericidal test with the standard tube dilution method. Antimicrob Agents Chemother. 1979 Jul;16(1):46–48. doi: 10.1128/aac.16.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rolston K. V. Group G streptococcal infections. Arch Intern Med. 1986 May;146(5):857–858. [PubMed] [Google Scholar]
  12. Sande M. A., Johnson M. L. Antimicrobial therapy of experimental endocarditis caused by Staphylococcus aureus. J Infect Dis. 1975 Apr;131(4):367–375. doi: 10.1093/infdis/131.4.367. [DOI] [PubMed] [Google Scholar]
  13. Vartian C., Lerner P. I., Shlaes D. M., Gopalakrishna K. V. Infections due to Lancefield group G streptococci. Medicine (Baltimore) 1985 Mar;64(2):75–88. doi: 10.1097/00005792-198503000-00001. [DOI] [PubMed] [Google Scholar]
  14. Venezio F. R., Gullberg R. M., Westenfelder G. O., Phair J. P., Cook F. V. Group G streptococcal endocarditis and bacteremia. Am J Med. 1986 Jul;81(1):29–34. doi: 10.1016/0002-9343(86)90178-6. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES