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. 1988 Jan;32(1):144–146. doi: 10.1128/aac.32.1.144

In vitro susceptibility of Trichomonas vaginalis to 50 antimicrobial agents.

S D Sears 1, J O'Hare 1
PMCID: PMC172117  PMID: 3258142

Abstract

We determined the susceptibilities of five strains of Trichomonas vaginalis, one of which was metronidazole resistant, to 50 antimicrobial agents. For the metronidazole-susceptible strains, the most active agents were metronidazole, tinidazole, mebendazole, furazolidone, and anisomycin. Against the resistant strain mebendazole, furazolidone, and anisomycin were the most active. Antifungal agents, beta-lactams, macrolides, aminoglycosides, and folic acid antagonists were ineffective against all strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DIAMOND L. S. The establishment of various trichomonads of animals and man in axenic cultures. J Parasitol. 1957 Aug;43(4):488–490. [PubMed] [Google Scholar]
  2. Dombrowski M. P., Sokol R. J., Brown W. J., Bronsteen R. A. Intravenous therapy of metronidazole-resistant Trichomonas vaginalis. Obstet Gynecol. 1987 Mar;69(3 Pt 2):524–525. [PubMed] [Google Scholar]
  3. Finegold S. M. Metronidazole. Ann Intern Med. 1980 Oct;93(4):585–587. doi: 10.7326/0003-4819-93-4-585. [DOI] [PubMed] [Google Scholar]
  4. Forsgren A., Forssman L. Metronidazole-resistant Trichomonas vaginalis. Br J Vener Dis. 1979 Oct;55(5):351–353. doi: 10.1136/sti.55.5.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Forsgren A., Wallin J. Trinidazole--a new preparation for Trichomonas vaginalis infections. I. Laboratory evaluation. Br J Vener Dis. 1974 Apr;50(2):146–147. doi: 10.1136/sti.50.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Koch-Weser J., Goldman P. Drug therapy: metronidazole. N Engl J Med. 1980 Nov 20;303(21):1212–1218. doi: 10.1056/NEJM198011203032106. [DOI] [PubMed] [Google Scholar]
  7. Krajden S., Lossick J. G., Wilk E., Yang J., Keystone J. S., Elliott K. Persistent Trichomonas vaginalis infection due to a metronidazole-resistant strain. CMAJ. 1986 Jun 15;134(12):1373–1374. [PMC free article] [PubMed] [Google Scholar]
  8. Krieger J. N., Dickins C. S., Rein M. F. Use of a time-kill technique for susceptibility testing of Trichomonas vaginalis. Antimicrob Agents Chemother. 1985 Mar;27(3):332–336. doi: 10.1128/aac.27.3.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Legal H. P. The treatment of trichomonas and candida vaginitis with clotrimazole vaginal tablets. Postgrad Med J. 1974 Jul;50 (Suppl 1):81–83. [PubMed] [Google Scholar]
  10. Lohmeyer H. Treatment of candidiasis and trichomoniasis of the female genital tract. Postgrad Med J. 1974 Jul;50 (Suppl 1):78–79. [PubMed] [Google Scholar]
  11. Meingassner J. G., Havelec L., Mieth H. Studies on strain sensitivity of Trichomonas vaginalis to metronidazole. Br J Vener Dis. 1978 Apr;54(2):72–76. doi: 10.1136/sti.54.2.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Meingassner J. G., Mieth H., Czok R., Lindmark D. G., Müller M. Assay conditions and the demonstration of nitroimidazole resistance in Tritrichomonas foetus. Antimicrob Agents Chemother. 1978 Jan;13(1):1–3. doi: 10.1128/aac.13.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Meingassner J. G., Thurner J. Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles. Antimicrob Agents Chemother. 1979 Feb;15(2):254–257. doi: 10.1128/aac.15.2.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Müller M., Meingassner J. G., Miller W. A., Ledger W. J. Three metronidazole-resistant strains of Trichomonas vaginalis from the United States. Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 1):808–812. doi: 10.1016/s0002-9378(16)32741-7. [DOI] [PubMed] [Google Scholar]
  15. Schnell J. D. The incidence of vaginal candida and trichomonas infections and treatment of trichomonas vaginitis with clotrimazole. Postgrad Med J. 1974 Jul;50 (Suppl 1):79–81. [PubMed] [Google Scholar]
  16. Smith R. F., Di Domenico A. Measuring the in vitro susceptibility of Trichomonas vaginalis to metronidazole: a disk broth method. Sex Transm Dis. 1980 Jul-Sep;7(3):120–124. doi: 10.1097/00007435-198007000-00005. [DOI] [PubMed] [Google Scholar]

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