Abstract
Enterohepatic circulation of NY-198 in rats was studied. NY-198 glucuronide in the bile was rapidly hydrolyzed to NY-198 by the intestinal contents. Hydrolyzed and parent NY-198 in the bile were reabsorbed from the intestine. The amount of NY-198 in enterohepatic circulation was 59.8% of that excreted in the bile.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- GLAZKO A. J., DILL W. A., WOLF L. M. Observations on the metabolic disposition of chloramphenicol (chloromycetin) in the rat. J Pharmacol Exp Ther. 1952 Apr;104(4):452–458. [PubMed] [Google Scholar]
- Hirose T., Okezaki E., Kato H., Ito Y., Inoue M., Mitsuhashi S. In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrob Agents Chemother. 1987 Jun;31(6):854–859. doi: 10.1128/aac.31.6.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
- IUPAC Commission on the Nomenclature of Organic Chemistry (CON) and IUPAC-IUB Commission on Biochemical Nomenclature (CBN). The nomenclature of cyclitols. Tentative rules. Biochem J. 1969 Mar;112(1):17–28. doi: 10.1042/bj1120017. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEWART G. T., HARRISON P. M. Excretion and re-excretion of a broad-spectrum penicillin in bile. Br J Pharmacol Chemother. 1961 Dec;17:414–419. doi: 10.1111/j.1476-5381.1961.tb01127.x. [DOI] [PMC free article] [PubMed] [Google Scholar]