Skip to main content
Archives of Disease in Childhood. Fetal and Neonatal Edition logoLink to Archives of Disease in Childhood. Fetal and Neonatal Edition
. 2001 Mar;84(2):F90–F91. doi: 10.1136/fn.84.2.F90

Brain specific proteins in posthaemorrhagic ventricular dilatation

A Whitelaw, L Rosengren, M Blennow
PMCID: PMC1721221  PMID: 11207222

Abstract

Median neurofilament and glial fibrillary acidic protein concentrations in the cerebrospinal fluid of 18 infants with posthaemorrhagic ventricular dilatation were 20-200 times higher than control values. S-100 protein in cerebrospinal fluid was four times higher than control values. Glial fibrillary acidic protein concentrations correlated with death or disability and with parenchymal lesions but not with shunt dependence.



Full Text

The Full Text of this article is available as a PDF (58.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aurell A., Rosengren L. E., Karlsson B., Olsson J. E., Zbornikova V., Haglid K. G. Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction. Stroke. 1991 Oct;22(10):1254–1258. doi: 10.1161/01.str.22.10.1254. [DOI] [PubMed] [Google Scholar]
  2. Blennow M., Rosengren L., Jonsson S., Forssberg H., Katz-Salamon M., Hagberg H., Hesser U., Lagercrantz H. Glial fibrillary acidic protein is increased in the cerebrospinal fluid of preterm infants with abnormal neurological findings. Acta Paediatr. 1996 Apr;85(4):485–489. doi: 10.1111/j.1651-2227.1996.tb14068.x. [DOI] [PubMed] [Google Scholar]
  3. Persson L., Hårdemark H. G., Gustafsson J., Rundström G., Mendel-Hartvig I., Esscher T., Påhlman S. S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke. 1987 Sep-Oct;18(5):911–918. doi: 10.1161/01.str.18.5.911. [DOI] [PubMed] [Google Scholar]
  4. Rosengren L. E., Karlsson J. E., Karlsson J. O., Persson L. I., Wikkelsø C. Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF. J Neurochem. 1996 Nov;67(5):2013–2018. doi: 10.1046/j.1471-4159.1996.67052013.x. [DOI] [PubMed] [Google Scholar]
  5. Rosengren L. E., Wikkelsø C., Hagberg L. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of adults. J Neurosci Methods. 1994 Mar;51(2):197–204. doi: 10.1016/0165-0270(94)90011-6. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood. Fetal and Neonatal Edition are provided here courtesy of BMJ Publishing Group

RESOURCES