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. 2001 May;84(3):F211–F215. doi: 10.1136/fn.84.3.F211

Nucleated red blood cells in the fetus and newborn

M Hermansen
PMCID: PMC1721260  PMID: 11320052

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Selected References

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  1. Altshuler G. Some placental considerations related to neurodevelopmental and other disorders. J Child Neurol. 1993 Jan;8(1):78–94. doi: 10.1177/088307389300800111. [DOI] [PubMed] [Google Scholar]
  2. Axt R., Ertan K., Hendrik J., Wrobel M., Mink D., Schmidt W. Nucleated red blood cells in cord blood of singleton term and post-term neonates. J Perinat Med. 1999;27(5):376–381. doi: 10.1515/JPM.1999.051. [DOI] [PubMed] [Google Scholar]
  3. Baschat A. A., Gembruch U., Reiss I., Gortner L., Harman C. R., Weiner C. P. Neonatal nucleated red blood cell counts in growth-restricted fetuses: relationship to arterial and venous Doppler studies. Am J Obstet Gynecol. 1999 Jul;181(1):190–195. doi: 10.1016/s0002-9378(99)70458-8. [DOI] [PubMed] [Google Scholar]
  4. Benirschke K. Placenta pathology questions to the perinatologist. J Perinatol. 1994 Sep-Oct;14(5):371–375. [PubMed] [Google Scholar]
  5. Bernstein P. S., Minior V. K., Divon M. Y. Neonatal nucleated red blood cell counts in small-for-gestational age fetuses with abnormal umbilical artery Doppler studies. Am J Obstet Gynecol. 1997 Nov;177(5):1079–1084. doi: 10.1016/s0002-9378(97)70018-8. [DOI] [PubMed] [Google Scholar]
  6. Blackwell S. C., Refuerzo J. S., Wolfe H. M., Hassan S. S., Berry S. M., Sokol R. J., Sorokin Y. The relationship between nucleated red blood cell counts and early-onset neonatal seizures. Am J Obstet Gynecol. 2000 Jun;182(6):1452–1457. doi: 10.1067/mob.2000.106854. [DOI] [PubMed] [Google Scholar]
  7. Buonocore G., Perrone S., Gioia D., Gatti M. G., Massafra C., Agosta R., Bracci R. Nucleated red blood cell count at birth as an index of perinatal brain damage. Am J Obstet Gynecol. 1999 Dec;181(6):1500–1505. doi: 10.1016/s0002-9378(99)70396-0. [DOI] [PubMed] [Google Scholar]
  8. De Waele M., Foulon W., Renmans W., Segers E., Smet L., Jochmans K., Van Camp B. Hematologic values and lymphocyte subsets in fetal blood. Am J Clin Pathol. 1988 Jun;89(6):742–746. doi: 10.1093/ajcp/89.6.742. [DOI] [PubMed] [Google Scholar]
  9. Eckardt K. U., Boutellier U., Kurtz A., Schopen M., Koller E. A., Bauer C. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol (1985) 1989 Apr;66(4):1785–1788. doi: 10.1152/jappl.1989.66.4.1785. [DOI] [PubMed] [Google Scholar]
  10. Eckardt K. U., Hartmann W., Vetter U., Pohlandt F., Burghardt R., Kurtz A. Serum immunoreactive erythropoietin of children in health and disease. Eur J Pediatr. 1990 Apr;149(7):459–464. doi: 10.1007/BF01959395. [DOI] [PubMed] [Google Scholar]
  11. Finch C. A., Deubelbeiss K., Cook J. D., Eschbach J. W., Harker L. A., Funk D. D., Marsaglia G., Hillman R. S., Slichter S., Adamson J. W. Ferrokinetics in man. Medicine (Baltimore) 1970 Jan;49(1):17–53. doi: 10.1097/00005792-197001000-00002. [DOI] [PubMed] [Google Scholar]
  12. Forestier F., Daffos F., Catherine N., Renard M., Andreux J. P. Developmental hematopoiesis in normal human fetal blood. Blood. 1991 Jun 1;77(11):2360–2363. [PubMed] [Google Scholar]
  13. Fox H. The incidence and significance of nucleated erythrocytes in the foetal vessels of the mature human placenta. J Obstet Gynaecol Br Commonw. 1967 Feb;74(1):40–43. doi: 10.1111/j.1471-0528.1967.tb03930.x. [DOI] [PubMed] [Google Scholar]
  14. Green D. W., Hendon B., Mimouni F. B. Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates. Pediatrics. 1995 Sep;96(3 Pt 1):475–478. [PubMed] [Google Scholar]
  15. Green D. W., Mimouni F. Nucleated erythrocytes in healthy infants and in infants of diabetic mothers. J Pediatr. 1990 Jan;116(1):129–131. doi: 10.1016/s0022-3476(05)81662-2. [DOI] [PubMed] [Google Scholar]
  16. Hanion-Lundberg K. M., Kirby R. S., Gandhi S., Broekhuizen F. F. Nucleated red blood cells in cord blood of singleton term neonates. Am J Obstet Gynecol. 1997 Jun;176(6):1149–1156. doi: 10.1016/s0002-9378(97)70328-4. [DOI] [PubMed] [Google Scholar]
  17. Hanlon-Lundberg K. M., Kirby R. S. Nucleated red blood cells as a marker of acidemia in term neonates. Am J Obstet Gynecol. 1999 Jul;181(1):196–201. doi: 10.1016/s0002-9378(99)70459-x. [DOI] [PubMed] [Google Scholar]
  18. Iversen P. O. Blood flow to the haemopoietic bone marrow. Acta Physiol Scand. 1997 Apr;159(4):269–276. doi: 10.1046/j.1365-201X.1997.00107.x. [DOI] [PubMed] [Google Scholar]
  19. Iversen P. O., Nicolaysen G., Benestad H. B. Blood flow to bone marrow during development of anemia or polycythemia in the rat. Blood. 1992 Feb 1;79(3):594–601. [PubMed] [Google Scholar]
  20. Korst L. M., Phelan J. P., Ahn M. O., Martin G. I. Nucleated red blood cells: an update on the marker for fetal asphyxia. Am J Obstet Gynecol. 1996 Oct;175(4 Pt 1):843–846. doi: 10.1016/s0002-9378(96)80010-x. [DOI] [PubMed] [Google Scholar]
  21. Leikin E., Garry D., Visintainer P., Verma U., Tejani N. Correlation of neonatal nucleated red blood cell counts in preterm infants with histologic chorioamnionitis. Am J Obstet Gynecol. 1997 Jul;177(1):27–30. doi: 10.1016/s0002-9378(97)70433-2. [DOI] [PubMed] [Google Scholar]
  22. Leikin E., Verma U., Klein S., Tejani N. Relationship between neonatal nucleated red blood cell counts and hypoxic-ischemic injury. Obstet Gynecol. 1996 Mar;87(3):439–443. doi: 10.1016/0029-7844(95)00436-x. [DOI] [PubMed] [Google Scholar]
  23. Maier R. F., Böhme K., Dudenhausen J. W., Obladen M. Cord blood erythropoietin in relation to different markers of fetal hypoxia. Obstet Gynecol. 1993 Apr;81(4):575–580. [PubMed] [Google Scholar]
  24. Maier R. F., Günther A., Vogel M., Dudenhausen J. W., Obladen M. Umbilical venous erythropoietin and umbilical arterial pH in relation to morphologic placental abnormalities. Obstet Gynecol. 1994 Jul;84(1):81–87. [PubMed] [Google Scholar]
  25. Mamopoulos M., Bili H., Tsantali C., Assimakopoulos E., Mantalenakis S., Farmakides G. Erythropoietin umbilical serum levels during labor in women with preeclampsia, diabetes, and preterm labor. Am J Perinatol. 1994 Nov;11(6):427–429. doi: 10.1055/s-2007-994612. [DOI] [PubMed] [Google Scholar]
  26. Manroe B. L., Weinberg A. G., Rosenfeld C. R., Browne R. The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr. 1979 Jul;95(1):89–98. doi: 10.1016/s0022-3476(79)80096-7. [DOI] [PubMed] [Google Scholar]
  27. McCormack M. K., Geller G. R., Zak S., Tukey D. P., Krivit W. Complex alpha-thalassemia-like syndrome: a cause of neonatal normoblastemia. J Pediatr. 1976 Sep;89(3):446–451. doi: 10.1016/s0022-3476(76)80548-3. [DOI] [PubMed] [Google Scholar]
  28. McMullin M. F., Lappin T. R., Elder G. E., Savage G. A., Bridges J. M. Erythropoietic response to hypobaric hypoxia in rabbits. Biomed Biochim Acta. 1988;47(6):523–527. [PubMed] [Google Scholar]
  29. Merenstein G. B., Blackmon L. R., Kushner J. Nucleated red-cells in the newborn. Lancet. 1970 Jun 13;1(7659):1293–1294. doi: 10.1016/s0140-6736(70)91773-3. [DOI] [PubMed] [Google Scholar]
  30. Mori T., Kaneko H., Kumagai M. A., Miyauchi J., Kaneko Y., Fujimoto J., Tsunematsu Y. Congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts: a case report and characterization of the blasts. Br J Haematol. 1997 Mar;96(4):740–742. doi: 10.1046/j.1365-2141.1997.d01-2106.x. [DOI] [PubMed] [Google Scholar]
  31. Naeye R. L., Localio A. R. Determining the time before birth when ischemia and hypoxemia initiated cerebral palsy. Obstet Gynecol. 1995 Nov;86(5):713–719. doi: 10.1016/0029-7844(95)00293-z. [DOI] [PubMed] [Google Scholar]
  32. Perrine S. P., Greene M. F., Lee P. D., Cohen R. A., Faller D. V. Insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia. Br J Haematol. 1986 Nov;64(3):503–511. doi: 10.1111/j.1365-2141.1986.tb02206.x. [DOI] [PubMed] [Google Scholar]
  33. Phelan J. P., Ahn M. O., Korst L. M., Martin G. I. Nucleated red blood cells: a marker for fetal asphyxia? Am J Obstet Gynecol. 1995 Nov;173(5):1380–1384. doi: 10.1016/0002-9378(95)90620-7. [DOI] [PubMed] [Google Scholar]
  34. Phelan J. P., Korst L. M., Ahn M. O., Martin G. I. Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury. Obstet Gynecol. 1998 Apr;91(4):485–489. doi: 10.1016/s0029-7844(98)00039-8. [DOI] [PubMed] [Google Scholar]
  35. Philip A. G., Tito A. M. Increased nucleated red blood cell counts in small for gestational age infants with very low birth weight. Am J Dis Child. 1989 Feb;143(2):164–169. doi: 10.1001/archpedi.1989.02150140050019. [DOI] [PubMed] [Google Scholar]
  36. Ruth V., Fyhrquist F., Clemons G., Raivio K. O. Cord plasma vasopressin, erythropoietin, and hypoxanthine as indices of asphyxia at birth. Pediatr Res. 1988 Oct;24(4):490–494. doi: 10.1203/00006450-198810000-00015. [DOI] [PubMed] [Google Scholar]
  37. Ruth V., Widness J. A., Clemons G., Raivio K. O. Postnatal changes in serum immunoreactive erythropoietin in relation to hypoxia before and after birth. J Pediatr. 1990 Jun;116(6):950–954. doi: 10.1016/s0022-3476(05)80659-6. [DOI] [PubMed] [Google Scholar]
  38. Salafia C. M., Ghidini A., Pezzullo J. C., Rosenkrantz T. S. Early neonatal nucleated erythrocyte counts in preterm deliveries: clinical and pathologic correlations. J Soc Gynecol Investig. 1997 May-Jun;4(3):138–143. doi: 10.1016/s1071-5576(97)00022-1. [DOI] [PubMed] [Google Scholar]
  39. Salvesen D. R., Brudenell J. M., Snijders R. J., Ireland R. M., Nicolaides K. H. Fetal plasma erythropoietin in pregnancies complicated by maternal diabetes mellitus. Am J Obstet Gynecol. 1993 Jan;168(1 Pt 1):88–94. doi: 10.1016/s0002-9378(12)90891-1. [DOI] [PubMed] [Google Scholar]
  40. Shivhare K., Chawla K., Khan M. A., Mathur P. S. Effect of maternal toxaemia on total haemoglobin, foetal haemoglobin and nucleated red blood cells in cord blood. Indian J Pediatr. 1976 Nov;43(346):349–356. doi: 10.1007/BF03177154. [DOI] [PubMed] [Google Scholar]
  41. Sills R. H., Hadley R. A. The significance of nucleated red blood cells in the peripheral blood of children. Am J Pediatr Hematol Oncol. 1983 Summer;5(2):173–177. [PubMed] [Google Scholar]
  42. Simpson J. L., Elias S. Isolating fetal cells from maternal blood. Advances in prenatal diagnosis through molecular technology. JAMA. 1993 Nov 17;270(19):2357–2361. [PubMed] [Google Scholar]
  43. Sinha H. B., Mukherjee A. K., Bala D. Cord blood haemoglobin (including foetal haemoglobin), and nucleated red cells in normal and toxaemic pregnancies. Indian Pediatr. 1972 Sep;9(9):540–543. [PubMed] [Google Scholar]
  44. Soothill P. W., Nicolaides K. H., Campbell S. Prenatal asphyxia, hyperlacticaemia, hypoglycaemia, and erythroblastosis in growth retarded fetuses. Br Med J (Clin Res Ed) 1987 Apr 25;294(6579):1051–1053. doi: 10.1136/bmj.294.6579.1051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Teramo K. A., Widness J. A., Clemons G. K., Voutilainen P., McKinlay S., Schwartz R. Amniotic fluid erythropoietin correlates with umbilical plasma erythropoietin in normal and abnormal pregnancy. Obstet Gynecol. 1987 May;69(5):710–716. [PubMed] [Google Scholar]
  46. Thilaganathan B., Athanasiou S., Ozmen S., Creighton S., Watson N. R., Nicolaides K. H. Umbilical cord blood erythroblast count as an index of intrauterine hypoxia. Arch Dis Child Fetal Neonatal Ed. 1994 May;70(3):F192–F194. doi: 10.1136/fn.70.3.f192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Varvarigou A., Beratis N. G., Makri M., Vagenakis A. G. Increased levels and positive correlation between erythropoietin and hemoglobin concentrations in newborn children of mothers who are smokers. J Pediatr. 1994 Mar;124(3):480–482. doi: 10.1016/s0022-3476(94)70380-9. [DOI] [PubMed] [Google Scholar]
  48. Voutilainen P. E., Widness J. A., Clemons G. K., Schwartz R., Teramo K. A. Amniotic fluid erythropoietin predicts fetal distress in Rh-immunized pregnancies. Am J Obstet Gynecol. 1989 Feb;160(2):429–434. doi: 10.1016/0002-9378(89)90466-3. [DOI] [PubMed] [Google Scholar]
  49. Widness J. A., Clemons G. K., Garcia J. F., Oh W., Schwartz R. Increased immunoreactive erythropoietin in cord serum after labor. Am J Obstet Gynecol. 1984 Jan 15;148(2):194–197. doi: 10.1016/s0002-9378(84)80175-1. [DOI] [PubMed] [Google Scholar]
  50. Widness J. A., Susa J. B., Garcia J. F., Singer D. B., Sehgal P., Oh W., Schwartz R., Schwartz H. C. Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses. J Clin Invest. 1981 Mar;67(3):637–642. doi: 10.1172/JCI110078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Widness J. A., Teramo K. A., Clemons G. K., Garcia J. F., Cavalieri R. L., Piasecki G. J., Jackson B. T., Susa J. B., Schwartz R. Temporal response of immunoreactive erythropoietin to acute hypoxemia in fetal sheep. Pediatr Res. 1986 Jan;20(1):15–19. doi: 10.1203/00006450-198601000-00004. [DOI] [PubMed] [Google Scholar]
  52. Yeruchimovich M., Dollberg S., Green D. W., Mimouni F. B. Nucleated red blood cells in infants of smoking mothers. Obstet Gynecol. 1999 Mar;93(3):403–406. doi: 10.1016/s0029-7844(98)00442-6. [DOI] [PubMed] [Google Scholar]
  53. Yeruchimovich M., Mimouni F. B., Green D. W., Dollberg S. Nucleated red blood cells in healthy infants of women with gestational diabetes. Obstet Gynecol. 2000 Jan;95(1):84–86. doi: 10.1016/s0029-7844(99)00511-6. [DOI] [PubMed] [Google Scholar]
  54. Young S. A., Crocker D. W. Occult congenital syphilis in macerated stillborn fetuses. Arch Pathol Lab Med. 1994 Jan;118(1):44–47. [PubMed] [Google Scholar]

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