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. 2001 Nov;85(3):F204–F206. doi: 10.1136/fn.85.3.F204

The influence of congenital heart disease on survival of infants with oesophageal atresia

H Leonard, A Barrett, J Scott, C Wren
PMCID: PMC1721336  PMID: 11668165

Abstract

OBJECTIVE—To examine the prevalence of congenital heart disease in babies with oesophageal atresia and its influence on outcome.
DESIGN—Retrospective analysis.
SETTING—The resident population of one health region.
RESULTS—A total of 153 babies with oesophageal atresia were identified from 509 975 live births (0.30 per 1000); 26 (17%) had cardiac defects. Survival of babies with normal hearts was 97%, 97%, and 95% at one week, one month, and one year. Survival of babies with congenital heart disease was 85%, 85%, and 67% at one week, one month, and one year, but only one of ten deaths was the result of the congenital heart disease. The remaining deaths were due to other congenital malformations, respiratory disease, or chromosome abnormalities.
CONCLUSIONS—There is a high prevalence of congenital heart disease in babies with oesophageal atresia. Congenital heart disease is associated with a higher mortality in oesophageal atresia but it is not the cause of it.



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Selected References

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  1. Bland J. M., Altman D. G. Statistics notes. The odds ratio. BMJ. 2000 May 27;320(7247):1468–1468. doi: 10.1136/bmj.320.7247.1468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chittmittrapap S., Spitz L., Kiely E. M., Brereton R. J. Oesophageal atresia and associated anomalies. Arch Dis Child. 1989 Mar;64(3):364–368. doi: 10.1136/adc.64.3.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Choudhury S. R., Ashcraft K. W., Sharp R. J., Murphy J. P., Snyder C. L., Sigalet D. L. Survival of patients with esophageal atresia: influence of birth weight, cardiac anomaly, and late respiratory complications. J Pediatr Surg. 1999 Jan;34(1):70–74. doi: 10.1016/s0022-3468(99)90231-2. [DOI] [PubMed] [Google Scholar]
  4. Ein S. H., Shandling B. Pure esophageal atresia: a 50-year review. J Pediatr Surg. 1994 Sep;29(9):1208–1211. doi: 10.1016/0022-3468(94)90802-8. [DOI] [PubMed] [Google Scholar]
  5. Greenwood R. D., Rosenthal A. Cardiovascular malformations associated with tracheoesophageal fistula and esophageal atresia. Pediatrics. 1976 Jan;57(1):87–91. [PubMed] [Google Scholar]
  6. Holder T. M., Ashcraft K. W., Sharp R. J., Amoury R. A. Care of infants with esophageal atresia, tracheoesophageal fistula, and associated anomalies. J Thorac Cardiovasc Surg. 1987 Dec;94(6):828–835. [PubMed] [Google Scholar]
  7. Kimble R. M., Harding J., Kolbe A. Additional congenital anomalies in babies with gut atresia or stenosis: when to investigate, and which investigation. Pediatr Surg Int. 1997;12(8):565–570. doi: 10.1007/BF01371900. [DOI] [PubMed] [Google Scholar]
  8. Mitchell S. C., Korones S. B., Berendes H. W. Congenital heart disease in 56,109 births. Incidence and natural history. Circulation. 1971 Mar;43(3):323–332. doi: 10.1161/01.cir.43.3.323. [DOI] [PubMed] [Google Scholar]
  9. Okada A., Usui N., Inoue M., Kawahara H., Kubota A., Imura K., Kamata S. Esophageal atresia in Osaka: a review of 39 years' experience. J Pediatr Surg. 1997 Nov;32(11):1570–1574. doi: 10.1016/s0022-3468(97)90455-3. [DOI] [PubMed] [Google Scholar]
  10. Poenaru D., Laberge J. M., Neilson I. R., Guttman F. M. A new prognostic classification for esophageal atresia. Surgery. 1993 Apr;113(4):426–432. [PubMed] [Google Scholar]
  11. Spitz L., Kiely E. M., Morecroft J. A., Drake D. P. Oesophageal atresia: at-risk groups for the 1990s. J Pediatr Surg. 1994 Jun;29(6):723–725. doi: 10.1016/0022-3468(94)90354-9. [DOI] [PubMed] [Google Scholar]
  12. Tulloh R. M., Tansey S. P., Parashar K., De Giovanni J. V., Wright J. G., Silove E. D. Echocardiographic screening in neonates undergoing surgery for selected gastrointestinal malformations. Arch Dis Child Fetal Neonatal Ed. 1994 May;70(3):F206–F208. doi: 10.1136/fn.70.3.f206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WATERSTON D. J., CARTER R. E., ABERDEEN E. Oesophageal atresia: tracheo-oesophageal fistula. A study of survival in 218 infants. Lancet. 1962 Apr 21;1(7234):819–822. doi: 10.1016/s0140-6736(62)91837-8. [DOI] [PubMed] [Google Scholar]
  14. Wren C., Richmond S., Donaldson L. Temporal variability in birth prevalence of cardiovascular malformations. Heart. 2000 Apr;83(4):414–419. doi: 10.1136/heart.83.4.414. [DOI] [PMC free article] [PubMed] [Google Scholar]

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