Abstract
The antimicrobial activities of josamycin, erythromycin, and spiramycin against Rickettsia conorii and R. rickettsii were evaluated in two tests: a dye-uptake assay and a plaque assay. The MIC of josamycin was 1 microgram/ml for both species; the MICs of erythromycin and spiramycin were 4 to 8 and 16 to 32 micrograms/ml, respectively, for both species. Only josamycin may be of clinical use in treating spotted fever rickettsiosis. It may be useful in treating pregnant women and young children.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Communiqué du Comité de l'Antibiogramme de la Société Française de la Microbiologie. Pathol Biol (Paris) 1985 May;33(5):295–296. [PubMed] [Google Scholar]
- Helmick C. G., Bernard K. W., D'Angelo L. J. Rocky Mountain spotted fever: clinical, laboratory, and epidemiological features of 262 cases. J Infect Dis. 1984 Oct;150(4):480–488. doi: 10.1093/infdis/150.4.480. [DOI] [PubMed] [Google Scholar]
- Miyamura S., Sato N., Tamura A. [In vitro susceptibility of recent clinical isolates of Rickettsia tsutsugamushi to chemotherapeutic agents]. Kansenshogaku Zasshi. 1985 May;59(5):486–488. doi: 10.11150/kansenshogakuzasshi1970.59.486. [DOI] [PubMed] [Google Scholar]
- Raoult D., Gallais H., De Micco P., Casanova P. Ciprofloxacin therapy for Mediterranean spotted fever. Antimicrob Agents Chemother. 1986 Oct;30(4):606–607. doi: 10.1128/aac.30.4.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raoult D., Roussellier P., Galicher V., Perez R., Tamalet J. In vitro susceptibility of Rickettsia conorii to ciprofloxacin as determined by suppressing lethality in chicken embryos and by plaque assay. Antimicrob Agents Chemother. 1986 Mar;29(3):424–425. doi: 10.1128/aac.29.3.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raoult D., Roussellier P., Vestris G., Galicher V., Perez R., Tamalet J. Susceptibility of Rickettsia conorii and R. rickettsii to pefloxacin, in vitro and in ovo. J Antimicrob Chemother. 1987 Mar;19(3):303–305. doi: 10.1093/jac/19.3.303. [DOI] [PubMed] [Google Scholar]
- Raoult D., Roussellier P., Vestris G., Tamalet J. In vitro antibiotic susceptibility of Rickettsia rickettsii and Rickettsia conorii: plaque assay and microplaque colorimetric assay. J Infect Dis. 1987 May;155(5):1059–1062. doi: 10.1093/infdis/155.5.1059. [DOI] [PubMed] [Google Scholar]
- Raoult D., Weiller P. J., Chagnon A., Chaudet H., Gallais H., Casanova P. Mediterranean spotted fever: clinical, laboratory and epidemiological features of 199 cases. Am J Trop Med Hyg. 1986 Jul;35(4):845–850. doi: 10.4269/ajtmh.1986.35.845. [DOI] [PubMed] [Google Scholar]
- Wisseman C. L., Jr, Waddell A. D., Walsh W. T. In vitro studies of the action of antibiotics on Rickettsia prowazeki by two basic methods of cell culture. J Infect Dis. 1974 Dec;130(6):564–574. doi: 10.1093/infdis/130.6.564. [DOI] [PubMed] [Google Scholar]