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. 2004 Sep;89(5):F436–F439. doi: 10.1136/adc.2003.029306

Prevalence of maternal dietary iodine insufficiency in the north east of England: implications for the fetus

M Kibirige, S Hutchison, C Owen, H Delves
PMCID: PMC1721745  PMID: 15321965

Abstract

Background: Maternal subclinical hypothyroidism is a cause of poor neurodevelopment outcome in the offspring. Although iodine deficiency is the most common cause of hypothyroidism world wide, there are no screening programmes for it in the United Kingdom where the population is assumed to be iodine replete.

Objective: To determine the prevalence of reduced iodine intake by measuring urinary iodide concentrations in pregnant and non-pregnant women from the north east of England.

Methods: Urinary iodide excretion (UIE) rate was estimated using inductively coupled mass spectrometry in 227 women at 15 weeks gestation and in 227 non-pregnant age matched controls. A reduced intake of iodine is indicated by a concentration in urine of less than 50 µg/l or less than 0.05 µg iodine/mmol creatinine.

Results: Eight (3.5%) pregnant women and 13 (5.7%) controls had a reduced iodine/creatinine ratio. These values were higher when UIE was expressed as iodine concentration: 16 (7%) and 20 (8.8%) respectively. Ninety (40%) of the pregnant women had a UIE of 0.05–0.10, which is consistent with borderline deficiency.

Conclusion: In this study, 3.5% of pregnant women had evidence of iodine deficiency, and 40% may be borderline deficient. Larger scale studies are required to estimate the true prevalence of iodine deficiency in the United Kingdom.

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Figure 1.

Figure 1

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 Distribution of iodine/creatinine ratio. A ratio of 0.05 shows iodine deficiency, and 0.05–0.10 is borderline.

Figure 2.

Figure 2

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 Iodine/creatinine ratio for Asian and white women.

Figure 3.

Figure 3

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 Box plots of log (urinary iodine concentration).

Figure 4.

Figure 4

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 Box plots of log (urinary iodine/creatinine ratio).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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