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. 1988 Mar;32(3):391–394. doi: 10.1128/aac.32.3.391

Reduced parasitemia observed with erythrocytes containing inositol hexaphosphate.

C L Mintzer 1, P Deloron 1, A Rice-Ficht 1, D Durica 1, D K Struck 1, C A Roessner 1, C Nicolau 1, G M Ihler 1
PMCID: PMC172182  PMID: 3364957

Abstract

Chemicals entrapped in erythrocytes by hypotonic hemolysis can be assessed for possible antiparasitic activity both in vivo and in vitro, regardless of whether they are able to diffuse into erythrocytes readily. Inositol hexaphosphate, a highly charged compound, produced a dramatic lowering of the percentage of cells infected by Babesia microti in vivo and both B. microti and Plasmodium falciparum in vitro. Several possible mechanisms for this observation are discussed.

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Selected References

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