Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1988 Apr;32(4):458–461. doi: 10.1128/aac.32.4.458

In vitro and in vivo activities of sedecamycin against Treponema hyodysenteriae.

T Hayashi 1, I Suenaga 1, N Narukawa 1, T Yamazaki 1
PMCID: PMC172201  PMID: 3377458

Abstract

Sedecamycin (lankacidin A), one of the lankacidin-group antibiotics, showed potent activity against Treponema hyodysenteriae. The MICs of sedecamycin against 79 field isolates of T. hyodysenteriae ranged from 0.78 to 12.5 micrograms/ml, the MIC for 90% of the strains tested (MIC90) being 3.13 micrograms/ml. The protective and therapeutic effects of sedecamycin were compared with those of carbadox, tiamulin, and lincomycin against experimental infection with T. hyodysenteriae in mice. The protective effect of sedecamycin was similar to that of carbadox, two times more potent than that of tiamulin, and three times greater than that of lincomycin. In the therapeutic test, sedecamycin showed activity similar to that of carbadox and was two times more active than both tiamulin and lincomycin. At doses of 10 mg or more of sedecamycin per kg, the recurrence of shedding of T. hyodysenteriae into the feces of mice was not detected for at least 8 weeks postmedication.

Full text

PDF
458

Images in this article

459Image
on p.459

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DeGeeter M. J., Harris D. L. Effect of lincomycin and spectinomycin on swine dysentery. J Anim Sci. 1975 Nov;41(5):1333–1338. doi: 10.2527/jas1975.4151333x. [DOI] [PubMed] [Google Scholar]
  2. Fugono T., Harada S., Higashide E., Kishi T. Studies on T-2636 antibiotics. 3. A new component, T-2636 F. J Antibiot (Tokyo) 1971 Jan;24(1):23–28. doi: 10.7164/antibiotics.24.23. [DOI] [PubMed] [Google Scholar]
  3. Harada S., Higashide E., Fugono T., Kishi T. Isolation and structures of T-2636 antibiotics. Tetrahedron Lett. 1969 Jun;(27):2239–2244. doi: 10.1016/s0040-4039(01)88131-4. [DOI] [PubMed] [Google Scholar]
  4. Harada S., Kishi T., Mizuno K. Studies on T-2636 antibiotics. II. Isolation and chemical properties of T-2636 antibiotics. J Antibiot (Tokyo) 1971 Jan;24(1):13–22. doi: 10.7164/antibiotics.24.13. [DOI] [PubMed] [Google Scholar]
  5. Harada S., Kishi T. Studies on lankacidin-group (T-2636) antibiotics. V. Chemical structures of lankacidin-group antibiotics. 1. Chem Pharm Bull (Tokyo) 1974 Jan;22(1):99–108. doi: 10.1248/cpb.22.99. [DOI] [PubMed] [Google Scholar]
  6. Harada S. Studies on lankacidin-group (T-2636) antibiotics. VI. Chemical structures of lankacidin-group antibiotics. II. Chem Pharm Bull (Tokyo) 1975 Oct;23(10):2201–2210. doi: 10.1248/cpb.23.2201. [DOI] [PubMed] [Google Scholar]
  7. Harada S., Yamazaki T., Hatano K., Tsuchiya K., Kishi T. Studies on lankacidin-group (T-2636) antibiotics. VII. Structure-activity relationships of lankacidin-group antibiotics. J Antibiot (Tokyo) 1973 Nov;26(11):647–657. doi: 10.7164/antibiotics.26.647. [DOI] [PubMed] [Google Scholar]
  8. Harris D. L., Alexander T. J., Whipp S. C., Robinson I. M., Glock R. D., Matthews P. J. Swine dysentery: studies of gnotobiotic pigs inoculated with Treponema hyodysenteriae, Bacteroides vulgatus, and Fusobacterium necrophorum. J Am Vet Med Assoc. 1978 Feb 15;172(4):468–471. [PubMed] [Google Scholar]
  9. Harris D. L., Glock R. D., Christensen C. R., Kinyon J. M. Inoculation of pigs with Treponema hyodysenteriae (new species) and reproduction f the disease. Vet Med Small Anim Clin. 1972 Jan;67(1):61–64. [PubMed] [Google Scholar]
  10. Higashide E., Fugono T., Hatano K., Shibata M. Studies on T-2636 antibiotics. I. Taxonomy of Streptomyces rochei var. volubilis var. nov. and production of the antibiotics and an esterase. J Antibiot (Tokyo) 1971 Jan;24(1):1–12. [PubMed] [Google Scholar]
  11. Joens L. A., Robinson I. M., Glock R. D., Matthews P. J. Production of lesions in gnotobiotic mice by inoculation with Treponema hyodysenteriae. Infect Immun. 1981 Jan;31(1):504–506. doi: 10.1128/iai.31.1.504-506.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kamiya K., Harada S., Wada Y., Nishikawa M., Kishi T. X-ray analysis of an antibiotic, T-2636 A (Bundlin B). Tetrahedron Lett. 1969 Jun;(27):2245–2248. doi: 10.1016/s0040-4039(01)88132-6. [DOI] [PubMed] [Google Scholar]
  13. Kitai K., Kashiwazaki M., Adachi Y., Kume T., Arakawa A. In vitro activity of 39 antimicrobial agents against Treponema hyodysenteriae. Antimicrob Agents Chemother. 1979 Mar;15(3):392–395. doi: 10.1128/aac.15.3.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lemcke R. M., Bew J., Burrows M. R., Lysons R. J. The growth of Treponema hyodysenteriae and other porcine intestinal spirochaetes in a liquid medium. Res Vet Sci. 1979 May;26(3):315–319. [PubMed] [Google Scholar]
  15. Meyer R. C., Simon J., Byerly C. S. The etiology of swine dysentery. III. The role of selected gram-negative obligate anaerobes. Vet Pathol. 1975;12(1):46–54. doi: 10.1177/030098587501200107. [DOI] [PubMed] [Google Scholar]
  16. Nakao M., Kondo M., Tsuchiya K. Light and electron microscopy of the morphological response of Escherichia coli and Serratia marcescens to cefmenoxime (SCE-1365), a new broad-spectrum cephalosporin. J Antibiot (Tokyo) 1981 Aug;34(8):1046–1054. doi: 10.7164/antibiotics.34.1046. [DOI] [PubMed] [Google Scholar]
  17. Olson L. D., Rodabaugh D. E. Ronidazole in high concentrations in drinking water for treatment and prevention of diarrhea in swine dysentery. Am J Vet Res. 1976 Jul;37(7):757–761. [PubMed] [Google Scholar]
  18. Rainier R. H., Chalquest R. R., Babcock W. E., Thrasher G. W. Efficacy of carbadox in prevention of field outbreaks of swine dysentery. Vet Med Small Anim Clin. 1973 Feb;68(2):171–175. [PubMed] [Google Scholar]
  19. Rainier R. H., Harris D. L., Glock R. D., Kinyon J. M., Brauer M. A. Carbadox and lincomycin in the treatment and carrier state control of swine dysentery. Am J Vet Res. 1980 Sep;41(9):1349–1356. [PubMed] [Google Scholar]
  20. Raynaud J. P., Brunault G., Patterson E. B. A swine dysentery model for evaluation of drug prophylaxis: efficacy of various drugs in the control of swine dysentery. Am J Vet Res. 1981 Jan;42(1):51–53. [PubMed] [Google Scholar]
  21. Songer J. G., Kinyon J. M., Harris D. L. Selective medium for isolation of Treponema hyodysenteriae. J Clin Microbiol. 1976 Jul;4(1):57–60. doi: 10.1128/jcm.4.1.57-60.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Suenaga I., Yamazaki T. Experimental Treponema hyodysenteriae infection of mice. Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Aug;257(3):348–356. [PubMed] [Google Scholar]
  23. Suenaga I., Yamazaki T. Experimental infection with Treponema hyodysenteriae in nude mice. Zentralbl Bakteriol Mikrobiol Hyg A. 1983 Jul;254(4):528–533. [PubMed] [Google Scholar]
  24. Taylor D. J., Alexander T. J. The production of dysentery in swine by feeding cultures containing a spirochaete. Br Vet J. 1971 Nov;127(11):58–61. doi: 10.1016/s0007-1935(17)37282-2. [DOI] [PubMed] [Google Scholar]
  25. Tsuchiya K., Yamazaki T., Takeuchi Y., Oishi T. Studies on T-2636 antibiotics. IV. In vitro and in vivo antibacterial activity of T-2636 antibiotics. J Antibiot (Tokyo) 1971 Jan;24(1):29–41. doi: 10.7164/antibiotics.24.29. [DOI] [PubMed] [Google Scholar]
  26. Van Buren J. W. Comparison of lincomycin and carbadox for treatment and control of swine dysentery. Mod Vet Pract. 1981 Feb;62(2):142–144. [PubMed] [Google Scholar]
  27. Whipp S. C., Robinson I. M., Harris D. L., Glock R. D., Matthews P. J., Alexander T. J. Pathogenic synergism between Treponema hyodysenteriae and other selected anaerobes in gnotobiotic pigs. Infect Immun. 1979 Dec;26(3):1042–1047. doi: 10.1128/iai.26.3.1042-1047.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES