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. 1997 Feb;81(2):133–135. doi: 10.1136/bjo.81.2.133

Blood flow velocity in the extraocular vessels in chronic smokers

H Kaiser 1, A Schoetzau 1, J Flammer 1
PMCID: PMC1722124  PMID: 9059247

Abstract

AIMS—To determine blood flow velocity in the extraocular vessels in healthy, chronic smokers and to compare these blood flow velocities with those of healthy non-smokers.
METHODS—In 46 healthy chronic smokers and 189 healthy non-smokers, peak systolic velocity (PSV), end diastolic velocity (EDV), and the resistivity index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), lateral short posterior ciliary artery (LPCA), and medial short posterior ciliary artery (MPCA) by means of a colour Doppler device, Siemens Quantum 2000.The maximal (max) and minimal (min) velocities were measured in the central retinal vein (CRV). Only one eye was measured in each subject, and right and left eyes were chosen randomly. Blood flow velocities were compared with one way MANOVA and t tests. The influence of age, sex, systolic and diastolic blood pressure, as well as heart rate on blood flow velocity and RI were evaluated by an analysis of covariance. The potential differences of the influence of the covariables on blood flow variables in smokers and non-smokers were tested by calculating the interactions.
RESULTS—In the majority of measured vessels blood flow velocity was higher in smokers than in non-smokers. This difference was statistically significant in the OA, CRV, and LPCA. The RI indices were equal or slightly lower in smokers. Furthermore, smokers had significantly lower systolic and diastolic blood pressure. Heart rate was higher in smokers but this difference did not reach statistical significance.
CONCLUSIONS—Colour Doppler measurements may differ significantly in smokers compared with non-smokers. Therefore, smoking habits should be considered when interpreting colour Doppler imaging results, and comparing different groups of diseased or healthy subjects.



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Figure 1  .

Figure 1  

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Mean (SD) of peak systolic (PSV), end diastolic (EDV) blood flow velocities and resistivity indices in the ophthalmic artery in smokers and non-smokers.

Selected References

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  1. Aburn N. S., Sergott R. C. Orbital colour Doppler imaging. Eye (Lond) 1993;7(Pt 5):639–647. doi: 10.1038/eye.1993.147. [DOI] [PubMed] [Google Scholar]
  2. Benowitz N. L., Kuyt F., Jacob P., 3rd Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking. Clin Pharmacol Ther. 1984 Jul;36(1):74–81. doi: 10.1038/clpt.1984.142. [DOI] [PubMed] [Google Scholar]
  3. Brunel P., Girerd X., Laurent S., Pannier B., Safar M. Acute changes in forearm haemodynamics produced by cigarette smoking in healthy normotensive non-smokers are not influenced by propranolol or pindolol. Eur J Clin Pharmacol. 1992;42(2):143–146. doi: 10.1007/BF00278473. [DOI] [PubMed] [Google Scholar]
  4. Cryer P. E., Haymond M. W., Santiago J. V., Shah S. D. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med. 1976 Sep 9;295(11):573–577. doi: 10.1056/NEJM197609092951101. [DOI] [PubMed] [Google Scholar]
  5. Erickson S. J., Hendrix L. E., Massaro B. M., Harris G. J., Lewandowski M. F., Foley W. D., Lawson T. L. Color Doppler flow imaging of the normal and abnormal orbit. Radiology. 1989 Nov;173(2):511–516. doi: 10.1148/radiology.173.2.2678264. [DOI] [PubMed] [Google Scholar]
  6. Goldbourt U., Medalie J. H. Characteristics of smokers, non-smokers and ex-smokers among 10,000 adult males inIsrael. II. Physiologic, biochemical and genetic characteristics. Am J Epidemiol. 1977 Jan;105(1):75–86. doi: 10.1093/oxfordjournals.aje.a112358. [DOI] [PubMed] [Google Scholar]
  7. Green M. S., Jucha E., Luz Y. Blood pressure in smokers and nonsmokers: epidemiologic findings. Am Heart J. 1986 May;111(5):932–940. doi: 10.1016/0002-8703(86)90645-9. [DOI] [PubMed] [Google Scholar]
  8. Guthoff R. F., Berger R. W., Winkler P., Helmke K., Chumbley L. C. Doppler ultrasonography of the ophthalmic and central retinal vessels. Arch Ophthalmol. 1991 Apr;109(4):532–536. doi: 10.1001/archopht.1991.01080040100037. [DOI] [PubMed] [Google Scholar]
  9. Kaiser H. J., Schötzau A., Flammer J. Blood-flow velocities in the extraocular vessels in normal volunteers. Am J Ophthalmol. 1996 Sep;122(3):364–370. doi: 10.1016/s0002-9394(14)72063-x. [DOI] [PubMed] [Google Scholar]
  10. Kurihara S. Effect of age on blood pressure response to cigarette smoking. Cardiology. 1995;86(2):102–107. doi: 10.1159/000176848. [DOI] [PubMed] [Google Scholar]
  11. Laby D. M., Nasrallah F. P., Butrus S. I., Whitmore P. V. Treatment of outer retinal necrosis in AIDS patients. Graefes Arch Clin Exp Ophthalmol. 1993 May;231(5):271–273. doi: 10.1007/BF00919104. [DOI] [PubMed] [Google Scholar]
  12. Lee B. L., Benowitz N. L., Jacob P., 3rd Influence of tobacco abstinence on the disposition kinetics and effects of nicotine. Clin Pharmacol Ther. 1987 Apr;41(4):474–479. doi: 10.1038/clpt.1987.59. [DOI] [PubMed] [Google Scholar]
  13. Lieb W. E., Cohen S. M., Merton D. A., Shields J. A., Mitchell D. G., Goldberg B. B. Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol. 1991 Apr;109(4):527–531. doi: 10.1001/archopht.1991.01080040095036. [DOI] [PubMed] [Google Scholar]
  14. Lieb W. E. Color Doppler ultrasonography of the eye and orbit. Curr Opin Ophthalmol. 1993 Jun;4(3):68–75. doi: 10.1097/00055735-199306000-00012. [DOI] [PubMed] [Google Scholar]
  15. Merritt C. R. Doppler color flow imaging. J Clin Ultrasound. 1987 Nov-Dec;15(9):591–597. doi: 10.1002/jcu.1870150904. [DOI] [PubMed] [Google Scholar]
  16. Morgado P. B., Chen H. C., Patel V., Herbert L., Kohner E. M. The acute effect of smoking on retinal blood flow in subjects with and without diabetes. Ophthalmology. 1994 Jul;101(7):1220–1226. doi: 10.1016/s0161-6420(94)31185-7. [DOI] [PubMed] [Google Scholar]
  17. Scoutt L. M., Zawin M. L., Taylor K. J. Doppler US. Part II. Clinical applications. Radiology. 1990 Feb;174(2):309–319. doi: 10.1148/radiology.174.2.2404310. [DOI] [PubMed] [Google Scholar]
  18. Tachmes L., Fernandez R. J., Sackner M. A. Hemodynamic effects of smoking cigarettes of high and low nicotine content. Chest. 1978 Sep;74(3):243–246. doi: 10.1378/chest.74.3.243. [DOI] [PubMed] [Google Scholar]
  19. Taylor K. J., Holland S. Doppler US. Part I. Basic principles, instrumentation, and pitfalls. Radiology. 1990 Feb;174(2):297–307. doi: 10.1148/radiology.174.2.2404309. [DOI] [PubMed] [Google Scholar]
  20. Trap-Jensen J. Effects of smoking on the heart and peripheral circulation. Am Heart J. 1988 Jan;115(1 Pt 2):263–267. doi: 10.1016/0002-8703(88)90647-3. [DOI] [PubMed] [Google Scholar]
  21. Williamson T. H., Baxter G. M., Dutton G. N. Colour Doppler velocimetry of the arterial vasculature of the optic nerve head and orbit. Eye (Lond) 1993;7(Pt 1):74–79. doi: 10.1038/eye.1993.16. [DOI] [PubMed] [Google Scholar]
  22. Williamson T. H., Lowe G. D., Baxter G. M. Influence of age, systemic blood pressure, smoking, and blood viscosity on orbital blood velocities. Br J Ophthalmol. 1995 Jan;79(1):17–22. doi: 10.1136/bjo.79.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]

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