Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1998 Jan;82(1):63–66. doi: 10.1136/bjo.82.1.63

Adjunctive use of mitomycin C on endoscopic lacrimal surgery

Y Anadolu 1, T Akturk 1
PMCID: PMC1722355  PMID: 9536884

Abstract

AIMS—Endoscopic endonasal dacryocystorhinostomy (DCR) has some advantages over external DCR as a less invasive method with no skin incisions. But the success rate of the operation has not reached the level of external method. In this study, a wound healing inhibitor mitomycin C was used intraoperatively to prevent the closure of the osteum after the operation.
METHODS—Endoscopic endonasal DCR was performed on 40 eyes of 39 patients (26 female, 13 male). Mitomycin C was applied to the ostium in 14 of 23 patients who had undergone primary endoscopic DCR by means of a microdrill and in eight of 17 patients who had a revision endoscopic DCR secondary to a previously failed external DCR.
RESULTS—The postoperative follow up period was 9-27 (mean 18.2) months. The success rate of endoscopic DCR with intraoperative mitomycin C was 77.3%, whereas the success rate of endoscopic DCR without mitomycin C was 77.8%. The statistical analysis did not show a difference between the two groups according to the ostium size and their success rates.
CONCLUSIONS—Adjunctive use of a wound healing inhibitor is considered to increase the success rate of endoscopic endonasal DCR. Its intraoperative use seems to be easy and safe. But the study of this limited series shows no benefit in using it.

 Keywords: mytomycin C; lacrimal surgery; dacryocystorhinostomy

Full Text

The Full Text of this article is available as a PDF (93.5 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergstrom T. J., Wilkinson W. S., Skuta G. L., Watnick R. L., Elner V. M. The effects of subconjunctival mitomycin-C on glaucoma filtration surgery in rabbits. Arch Ophthalmol. 1991 Dec;109(12):1725–1730. doi: 10.1001/archopht.1991.01080120109038. [DOI] [PubMed] [Google Scholar]
  2. Boush G. A., Lemke B. N., Dortzbach R. K. Results of endonasal laser-assisted dacryocystorhinostomy. Ophthalmology. 1994 May;101(5):955–959. doi: 10.1016/s0161-6420(94)31231-0. [DOI] [PubMed] [Google Scholar]
  3. Burns J. A., Cahill K. V. Modified Kinosian dacryocystorhinostomy: a review of 122 cases. Ophthalmic Surg. 1985 Nov;16(11):710–716. [PubMed] [Google Scholar]
  4. Gonnering R. S., Lyon D. B., Fisher J. C. Endoscopic laser-assisted lacrimal surgery. Am J Ophthalmol. 1991 Feb 15;111(2):152–157. doi: 10.1016/s0002-9394(14)72252-4. [DOI] [PubMed] [Google Scholar]
  5. Hutchinson A. K., Grossniklaus H. E., Brown R. H., McManus P. E., Bradley C. K. Clinicopathologic features of excised mitomycin filtering blebs. Arch Ophthalmol. 1994 Jan;112(1):74–79. doi: 10.1001/archopht.1994.01090130084023. [DOI] [PubMed] [Google Scholar]
  6. Iliff C. E. A simplified dacryocystorhinostomy. 1954-1970. Arch Ophthalmol. 1971 May;85(5):586–591. doi: 10.1001/archopht.1971.00990050588011. [DOI] [PubMed] [Google Scholar]
  7. Jampel H. D. Effect of brief exposure to mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts. Ophthalmology. 1992 Sep;99(9):1471–1476. doi: 10.1016/s0161-6420(92)31781-6. [DOI] [PubMed] [Google Scholar]
  8. Kong Y. T., Kim T. I., Kong B. W. A report of 131 cases of endoscopic laser lacrimal surgery. Ophthalmology. 1994 Nov;101(11):1793–1800. doi: 10.1016/s0161-6420(94)31100-6. [DOI] [PubMed] [Google Scholar]
  9. Lee D. A. Antifibrosis agents and glaucoma surgery. Invest Ophthalmol Vis Sci. 1994 Oct;35(11):3789–3791. [PubMed] [Google Scholar]
  10. Linberg J. V., Anderson R. L., Bumsted R. M., Barreras R. Study of intranasal ostium external dacryocystorhinostomy. Arch Ophthalmol. 1982 Nov;100(11):1758–1762. doi: 10.1001/archopht.1982.01030040738005. [DOI] [PubMed] [Google Scholar]
  11. Massaro B. M., Gonnering R. S., Harris G. J. Endonasal laser dacryocystorhinostomy. A new approach to nasolacrimal duct obstruction. Arch Ophthalmol. 1990 Aug;108(8):1172–1176. doi: 10.1001/archopht.1990.01070100128048. [DOI] [PubMed] [Google Scholar]
  12. McDonogh M., Meiring J. H. Endoscopic transnasal dacryocystorhinostomy. J Laryngol Otol. 1989 Jun;103(6):585–587. doi: 10.1017/s0022215100109405. [DOI] [PubMed] [Google Scholar]
  13. Metson R. Endoscopic surgery for lacrimal obstruction. Otolaryngol Head Neck Surg. 1991 Apr;104(4):473–479. doi: 10.1177/019459989110400408. [DOI] [PubMed] [Google Scholar]
  14. Metson R. The endoscopic approach for revision dacryocystorhinostomy. Laryngoscope. 1990 Dec;100(12):1344–1347. doi: 10.1288/00005537-199012000-00020. [DOI] [PubMed] [Google Scholar]
  15. Palmer S. S. Mitomycin as adjunct chemotherapy with trabeculectomy. Ophthalmology. 1991 Mar;98(3):317–321. doi: 10.1016/s0161-6420(91)32293-0. [DOI] [PubMed] [Google Scholar]
  16. Ugurbas S. H., Zilelioglu G., Sargon M. F., Anadolu Y., Akiner M., Aktürk T. Histopathologic effects of mitomycin-C on endoscopic transnasal dacryocystorhinostomy. Ophthalmic Surg Lasers. 1997 Apr;28(4):300–304. [PubMed] [Google Scholar]
  17. Walland M. J., Rose G. E. Factors affecting the success rate of open lacrimal surgery. Br J Ophthalmol. 1994 Dec;78(12):888–891. doi: 10.1136/bjo.78.12.888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Welham R. A., Wulc A. E. Management of unsuccessful lacrimal surgery. Br J Ophthalmol. 1987 Feb;71(2):152–157. doi: 10.1136/bjo.71.2.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Whittet H. B., Shun-Shin G. A., Awdry P. Functional endoscopic transnasal dacryocystorhinostomy. Eye (Lond) 1993;7(Pt 4):545–549. doi: 10.1038/eye.1993.119. [DOI] [PubMed] [Google Scholar]
  20. Woog J. J., Metson R., Puliafito C. A. Holmium:YAG endonasal laser dacryocystorhinostomy. Am J Ophthalmol. 1993 Jul 15;116(1):1–10. doi: 10.1016/s0002-9394(14)71736-2. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES