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. 1998 Oct;82(10):1159–1161. doi: 10.1136/bjo.82.10.1159

Frequency of asymptomatic choroidal metastasis in patients with disseminated breast cancer: results of a prospective screening programme

T Wiegel 1, K M Kreusel 1, N Bornfeld 1, D Bottke 1, M Stange 1, M Foerster 1, W Hinkelbein 1
PMCID: PMC1722389  PMID: 9924304

Abstract

AIM—To determine the frequency of visually asymptomatic choroidal metastasis in patients with disseminated breast cancer and its dependence on the incidence of metastasis by number and site of other organ metastases.
METHODS—From January 1995 until April 1997 120 patients irradiated for disseminated breast cancer underwent ophthalmological screening for choroidal metastasis. No patient was symptomatic for ocular disease. 68 out of 120 patients were found to have metastases in one organ and 52 patients had metastases in more than one organ. 80% of the patients had bone metastases, 25% lung metastases, 22% liver metastases, 15% brain metastases, and 22% had metastases in other organs.
RESULTS—Six patients (5%) were found to have asymptomatic choroidal metastases. Five patients had unilateral and one patient bilateral metastases. 52 patients with more than one involved organ had a significantly higher risk for asymptomatic choroidal metastasis (6/52, 11%) than 68 patients with metastases in only one organ (0/68) (p=0.006). In univariate analysis a significantly higher risk was seen for patients with lung metastases (14% choroidal metastases versus 2% in patients without lung metastases, p=0.03) and for patients with brain metastases (17% choroidal metastases versus 3% in those without brain metastases, p=0.04).
CONCLUSION—In disseminated breast cancer the incidence of asymptomatic choroidal metastases was 5% and increased to 11% when more than one organ was involved in metastatic spread. Risk factors for choroidal metastases were dissemination of disease in more than one organ and the presence of lung and brain metastases.

 Keywords: choroidal metastasis; breast cancer; screening programme

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Figure 1  .

Figure 1  

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(A) Asymptomatic metastasis extending into the macula. Visual acuity was 20/20, sonographic prominence was 1.9 mm. (B) After external beam irradiation the metastasis showed complete regression and visual function could be preserved (follow up time 33 months).

Figure 2  .

Figure 2  

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Localisation and approximate extension of choroidal metastases detected. None of the metastases was symptomatic. Numbers indicate numbers of patients; in one patient metastases were found in both eyes.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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