Abstract
AIM—To identify cigarette smoking as a risk factor for development of cataract, to determine the importance of copper, lead, and cadmium in cataractogenesis, and to learn about any relation between those elements. METHODS—Copper, lead, and cadmium concentrations were measured by atomic absorption spectrophotometry in 37 cataractous and nine normal human lenses. RESULTS—All three element accumulations in lenses with cataract were statistically meaningful. Lenticular copper, lead, and cadmium were increased significantly with cigarette smoking. Cadmium had a positive correlation both with lead and copper in cataractous lenses. CONCLUSION—The accumulation of copper, lead, and cadmium occurs in cataract. The probable source of cadmium in humans is cigarettes. Lenticular cadmium accumulation also increases copper and lead precipitation in the lens. Cigarette smoking might be cataractogenic. Keywords: cigarettes; cataract; copper; lead; cadmium
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- Balaji M., Sasikala K., Ravindran T. Copper levels in human mixed, nuclear brunescence, and posterior subcapsular cataract. Br J Ophthalmol. 1992 Nov;76(11):668–669. doi: 10.1136/bjo.76.11.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Christen W. G., Manson J. E., Seddon J. M., Glynn R. J., Buring J. E., Rosner B., Hennekens C. H. A prospective study of cigarette smoking and risk of cataract in men. JAMA. 1992 Aug 26;268(8):989–993. [PubMed] [Google Scholar]
- Clayton R. M., Cuthbert J., Duffy J., Seth J., Phillips C. I., Bartholomew R. S., Reid J. M. Some risk factors associated with cataract in S.E. Scotland: a pilot study. Trans Ophthalmol Soc U K. 1982;102(Pt 3):331–336. [PubMed] [Google Scholar]
- Flaye D. E., Sullivan K. N., Cullinan T. R., Silver J. H., Whitelocke R. A. Cataracts and cigarette smoking. The City Eye Study. Eye (Lond) 1989;3(Pt 4):379–384. doi: 10.1038/eye.1989.56. [DOI] [PubMed] [Google Scholar]
- Hankinson S. E., Willett W. C., Colditz G. A., Seddon J. M., Rosner B., Speizer F. E., Stampfer M. J. A prospective study of cigarette smoking and risk of cataract surgery in women. JAMA. 1992 Aug 26;268(8):994–998. [PubMed] [Google Scholar]
- Harding J. J. Cigarette smoking and risk of cataracts. JAMA. 1993 Feb 10;269(6):747–748. doi: 10.1001/jama.269.6.747c. [DOI] [PubMed] [Google Scholar]
- Harding J. J., van Heyningen R. Beer, cigarettes and military work as risk factors for cataract. Dev Ophthalmol. 1989;17:13–16. doi: 10.1159/000416990. [DOI] [PubMed] [Google Scholar]
- Harding J. J., van Heyningen R. Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide. Br J Ophthalmol. 1988 Nov;72(11):809–814. doi: 10.1136/bjo.72.11.809. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klein B. E., Klein R., Moss S. E. Prevalence of cataracts in a population-based study of persons with diabetes mellitus. Ophthalmology. 1985 Sep;92(9):1191–1196. doi: 10.1016/s0161-6420(85)33877-0. [DOI] [PubMed] [Google Scholar]
- Leske M. C., Chylack L. T., Jr, Wu S. Y. The Lens Opacities Case-Control Study. Risk factors for cataract. Arch Ophthalmol. 1991 Feb;109(2):244–251. doi: 10.1001/archopht.1991.01080020090051. [DOI] [PubMed] [Google Scholar]
- Nath R., Srivastava S. K., Singh K. Accumulation of copper and inhibition of lactate dehydrogenase activity in human senile cataractous lens. Indian J Exp Biol. 1969 Jan;7(1):25–26. [PubMed] [Google Scholar]
- Ramakrishnan S., Sulochana K. N., Selvaraj T., Abdul Rahim A., Lakshmi M., Arunagiri K. Smoking of beedies and cataract: cadmium and vitamin C in the lens and blood. Br J Ophthalmol. 1995 Mar;79(3):202–206. doi: 10.1136/bjo.79.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reznick A. Z., Cross C. E., Hu M. L., Suzuki Y. J., Khwaja S., Safadi A., Motchnik P. A., Packer L., Halliwell B. Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation. Biochem J. 1992 Sep 1;286(Pt 2):607–611. doi: 10.1042/bj2860607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rácz P., Erdöhelyi A. Cadmium, lead and copper concentrations in normal and senile cataractous human lenses. Ophthalmic Res. 1988;20(1):10–13. doi: 10.1159/000266248. [DOI] [PubMed] [Google Scholar]
- Shukla N., Moitra J. K., Trivedi R. C. Determination of lead, zinc, potassium, calcium, copper and sodium in human cataract lenses. Sci Total Environ. 1996 Mar 15;181(2):161–165. doi: 10.1016/0048-9697(95)05006-x. [DOI] [PubMed] [Google Scholar]
- Sommer A. Cataracts as an epidemiologic problem. Am J Ophthalmol. 1977 Mar;83(3):334–339. doi: 10.1016/0002-9394(77)90729-2. [DOI] [PubMed] [Google Scholar]
- Swanson A. A., Truesdale A. W. Elemental analysis in normal and cataractous human lens tissue. Biochem Biophys Res Commun. 1971 Dec 17;45(6):1488–1496. doi: 10.1016/0006-291x(71)90188-4. [DOI] [PubMed] [Google Scholar]
- West S., Munoz B., Emmett E. A., Taylor H. R. Cigarette smoking and risk of nuclear cataracts. Arch Ophthalmol. 1989 Aug;107(8):1166–1169. doi: 10.1001/archopht.1989.01070020232031. [DOI] [PubMed] [Google Scholar]
- van Heyningen R., Harding J. J. A case-control study of cataract in Oxfordshire: some risk factors. Br J Ophthalmol. 1988 Nov;72(11):804–808. doi: 10.1136/bjo.72.11.804. [DOI] [PMC free article] [PubMed] [Google Scholar]