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. 1988 May;32(5):740–746. doi: 10.1128/aac.32.5.740

Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes.

G P Bongaerts 1, J S Vliegenthart 1
PMCID: PMC172263  PMID: 2840015

Abstract

Reaction rates of several reference aminoglycoside-modifying enzymes were studied at various substrate concentrations. The resulting concentration-response curves showed wide variation in threshold concentration, in curve slope, in enzyme saturation, and in substrate inhibition. Together, the curves of a defined aminoglycoside panel yielded more specific information for each individual aminoglycoside-modifying enzyme tested than did conventional substrate profiles obtained at a single substrate concentration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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