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. 1998 Jul;82(7):731–736. doi: 10.1136/bjo.82.7.731

Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects

L Fontana 1, D Poinoosawmy 1, C Bunce 1, C O'Brien 1, R Hitchings 1
PMCID: PMC1722652  PMID: 9924361

Abstract

AIMS—This study was designed to investigate pulsatile ocular blood flow (POBF) in normal tension glaucoma (NTG) patients and in normal controls. NTG patients with unilateral field loss were evaluated to compare POBF values between eyes with and without field loss.
METHODS—POBF measurements from more than 1500 subjects were collected during a period of 6 months from six optometric centres. Subjects with systemic vascular diseases (such as systemic hypertension and diabetes), ophthalmic diseases, a positive family history of glaucoma, and those individuals receiving treatment with systemic β blockers were excluded on the basis of a questionnaire. For comparison, 95 NTG patients with unilateral field loss, selected from 403 consecutive patients with NTG, underwent POBF testing. For each individual age, sex, intraocular pressure, refraction, and pulse rate were entered into a database.
RESULTS—Data from 777 subjects were included in the analysis. POBF measurements of patients and subjects were compared allowing for differences in age, sex, intraocular pressure, refraction, and pulse rate. POBF was significantly lower in eyes of NTG patients with and without field loss (p <0.001 and p = 0.01 respectively). Eyes of NTG patients with field loss showed significantly lower POBF than the contralateral eyes with normal field (p < 0.001).
CONCLUSIONS—POBF was significantly lower in eyes of NTG patients with and without field loss than in normal subjects, suggesting that differences in ocular blood perfusion are relevant to the development of NTG and are detectable from the early stage of the disease. Furthermore, the finding of lower POBF in NTG eyes with field loss than in the contralateral eyes with normal field suggests that haemodynamic differences between fellow eyes contribute to determine the side of onset of the disease. 

 Keywords: pulsatile ocular blood flow; normal tension glaucoma; visual field asymmetry

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Figure 1  .

Figure 1  

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Normal subjects (n = 777). Age and sex distribution.

Figure 2  .

Figure 2  

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Normal subjects, right eyes. Scattergram and linear regression analysis of the distribution of log POBF v age (n = 777; r = 0.142; r2 = 0.020; p <0.0001).

Figure 3  .

Figure 3  

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Normal subjects. Scattergram and linear regression analysis of the distribution of log POBF v age for men and women (n = 345; r = 0.140; r2 = 0.020; p = 0.009 for men and n = 430; r 0.166; r2 = 0.028; p = 0.001 for women).

Selected References

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