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. 1998 Jul;82(7):751–753. doi: 10.1136/bjo.82.7.751

Effect of plasma colloid osmotic pressure on intraocular pressure during haemodialysis

T Tokuyama 1, T Ikeda 1, K Sato 1
PMCID: PMC1722658  PMID: 9924365

Abstract

BACKGROUND—In a previous case report, it was shown that an increase in plasma colloid osmotic pressure induced by the removal of fluid during haemodialysis was instrumental in decreasing intraocular pressure. The relation between changes in intraocular pressure, plasma osmolarity, plasma colloid osmotic pressure, and body weight before and after haemodialysis is evaluated.
METHODS—Intraocular pressure, plasma osmolarity, plasma colloid osmotic pressure, and body weight were evaluated before and after haemodialysis in 36 patients.
RESULTS—Intraocular pressure and plasma osmolarity both decreased significantly after haemodialysis (p<0.0001). Plasma colloid osmotic pressure increased significantly after haemodialysis (p<0.0001). Body weight decreased significantly because of the removal of fluid during haemodialysis (p<0.0001). No significant correlation was found between the change in intraocular pressure and that in plasma osmolarity (r=−0.206, p=0.2297), whereas the change in intraocular pressure was correlated with the change in plasma colloid osmotic pressure (r=−0.510, p=0.0012) and the change in body weight (r=0.534, p=0.0006). A significant correlation was found between the change in plasma colloid osmotic pressure and that in body weight (r=−0.756, p<0.0001).
CONCLUSION—The change in intraocular pressure was inversely correlated with the increase in plasma colloid osmotic pressure caused by the removal of fluid during haemodialysis.

 Keywords: intraocular pressure; plasma colloid osmotic pressure; plasma osmolarity; haemodialysis

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Figure 1  .

Figure 1  

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(A) The lack of significant correlation between the change in intraocular pressure (IOP) and that of plasma osmolarity after haemodialysis (HD) (r=−0.206 p=0.2297). (B) Correlation between the change in IOP and that of plasma colloid osmotic pressure after HD (r=−0.510, p=0.0012).

Figure 2  .

Figure 2  

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Schematic diagram illustrating the movement of water during haemodialysis.4 The mechanism for the correction of a massive accumulation of fluid in the interstitial compartment, and for the reduction in intraocular pressure is illustrated. As a first step, a net movement of water from plasma into dialysate is caused by haemodialysis. As a consequence, plasma colloid osmotic pressure undergoes a relative increase in response to the decrease in plasma volume, because large proteins, such as albumin and globulin, cannot cross the membranes. A gradient of colloid osmotic pressure between plasma and interstitial fluid (or aqueous humour) causes a net movement of water from the interstitial fluid (or aqueous humour) into the plasma. Finally, the massive accumulation of interstitial fluid is corrected (or intraocular pressure decreases).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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