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. 1998 Aug;82(8):880–883. doi: 10.1136/bjo.82.8.880

Effects of short term increase of intraocular pressure on optic disc cupping

A Azuara-Blanco 1, A Harris 1, L Cantor 1, M Abreu 1, M Weinland 1
PMCID: PMC1722706  PMID: 9828770

Abstract

AIMS—To evaluate the effect of acute elevation of intraocular pressure (IOP) on optic disc cupping.
METHODS—10 emmetropic and 10 myopic volunteers were included in this study. The cup area (CA) and cup volume (CV) of the optic disc were determined with the Heidelberg retina tomograph (HRT). After baseline determinations, a suction cup was used to increase the intraocular pressure (IOP) to 20-25 mm Hg above the baseline and HRT images were obtained.
RESULTS—Baseline IOP was 13.5 (SD 1.3) mm Hg and 12.6 (2.6) mm Hg in the emmetropic and myopic groups, respectively. The IOP was elevated to 35.4 (3.3) mm Hg and 34.4 (2.5) mm Hg in the emmetropic and myopic groups, respectively. When compared with their baseline values, the cupping variables (CA and CV) were significantly increased (p<0.05) during the suction treatment in both emmetropic and myopic subjects.
CONCLUSION—There was a significant enlargement in the optic disc cupping during the artificial increment of intraocular pressure in both emmetropic and myopic eyes. In non-glaucomatous eyes the optic nerve head has a partially dynamic topography dependent upon the level of IOP.

 Keywords: optic disc; intraocular pressure; compliance; glaucoma

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Figure 1  .

Figure 1  

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Heidelberg retina tomograph values of cup volume.

Figure 2  .

Figure 2  

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Heidelberg retina tomograph values of cup area.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson D. R., Hendrickson A. Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest Ophthalmol. 1974 Oct;13(10):771–783. [PubMed] [Google Scholar]
  2. Burgoyne C. F., Quigley H. A., Thompson H. W., Vitale S., Varma R. Measurement of optic disc compliance by digitized image analysis in the normal monkey eye. Ophthalmology. 1995 Dec;102(12):1790–1799. doi: 10.1016/s0161-6420(95)30792-0. [DOI] [PubMed] [Google Scholar]
  3. Burgoyne C. F., Varma R., Quigley H. A., Vitale S., Pease M. E., Lenane P. L. Global and regional detection of induced optic disc change by digitized image analysis. Arch Ophthalmol. 1994 Feb;112(2):261–268. doi: 10.1001/archopht.1994.01090140137035. [DOI] [PubMed] [Google Scholar]
  4. Coleman A. L., Quigley H. A., Vitale S., Dunkelberger G. Displacement of the optic nerve head by acute changes in intraocular pressure in monkey eyes. Ophthalmology. 1991 Jan;98(1):35–40. doi: 10.1016/s0161-6420(91)32345-5. [DOI] [PubMed] [Google Scholar]
  5. Dreher A. W., Tso P. C., Weinreb R. N. Reproducibility of topographic measurements of the normal and glaucomatous optic nerve head with the laser tomographic scanner. Am J Ophthalmol. 1991 Feb 15;111(2):221–229. doi: 10.1016/s0002-9394(14)72263-9. [DOI] [PubMed] [Google Scholar]
  6. Galin M. A., Baras I., Cavero R., Best M. Compression and suction ophthalmodynamometry. Am J Ophthalmol. 1969 Mar;67(3):388–392. doi: 10.1016/0002-9394(69)92052-2. [DOI] [PubMed] [Google Scholar]
  7. Hernandez M. R., Luo X. X., Igoe F., Neufeld A. H. Extracellular matrix of the human lamina cribrosa. Am J Ophthalmol. 1987 Dec 15;104(6):567–576. doi: 10.1016/0002-9394(87)90165-6. [DOI] [PubMed] [Google Scholar]
  8. Hernandez M. R. Ultrastructural immunocytochemical analysis of elastin in the human lamina cribrosa. Changes in elastic fibers in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2891–2903. [PubMed] [Google Scholar]
  9. Irak I., Zangwill L., Garden V., Shakiba S., Weinreb R. N. Change in optic disk topography after trabeculectomy. Am J Ophthalmol. 1996 Nov;122(5):690–695. doi: 10.1016/s0002-9394(14)70488-x. [DOI] [PubMed] [Google Scholar]
  10. Jonas J. B., Gareis O., Naumann G. O. Optic disc topography and short-term increase in intraocular pressure. Graefes Arch Clin Exp Ophthalmol. 1990;228(6):524–527. doi: 10.1007/BF00918484. [DOI] [PubMed] [Google Scholar]
  11. Levy N. S., Crapps E. E. Displacement of optic nerve head in response to short-term intraocular pressure elevation in human eyes. Arch Ophthalmol. 1984 May;102(5):782–786. doi: 10.1001/archopht.1984.01040030630037. [DOI] [PubMed] [Google Scholar]
  12. Levy N. S. The effects of elevated intraocular pressure on slow axonal protein flow. Invest Ophthalmol. 1974 Sep;13(9):691–695. [PubMed] [Google Scholar]
  13. Quigley H. A., Brown A., Dorman-Pease M. E. Alterations in elastin of the optic nerve head in human and experimental glaucoma. Br J Ophthalmol. 1991 Sep;75(9):552–557. doi: 10.1136/bjo.75.9.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Quigley H. A. Childhood glaucoma: results with trabeculotomy and study of reversible cupping. Ophthalmology. 1982 Mar;89(3):219–226. doi: 10.1016/s0161-6420(82)34803-4. [DOI] [PubMed] [Google Scholar]
  15. Shaffer R. N., Hetherington J., Jr The glaucomatous disc in infants. A suggested hypothesis for disc cupping. Trans Am Acad Ophthalmol Otolaryngol. 1969 Sep-Oct;73(5):923–935. [PubMed] [Google Scholar]
  16. Shin D. H., Bielik M., Hong Y. J., Briggs K. S., Shi D. X. Reversal of glaucomatous optic disc cupping in adult patients. Arch Ophthalmol. 1989 Nov;107(11):1599–1603. doi: 10.1001/archopht.1989.01070020677026. [DOI] [PubMed] [Google Scholar]
  17. Shirakashi M., Nanba K., Iwata K. Changes in reversal of cupping in experimental glaucoma. Longitudinal study. Ophthalmology. 1992 Jul;99(7):1104–1110. doi: 10.1016/s0161-6420(92)31844-5. [DOI] [PubMed] [Google Scholar]
  18. Spaeth G. L. Reversibility of optic disc cupping. A phenomenon that may change the management of glaucoma. Arch Ophthalmol. 1989 Nov;107(11):1583–1584. doi: 10.1001/archopht.1989.01070020661022. [DOI] [PubMed] [Google Scholar]
  19. Ulrich W. D., Ulrich C., Neunhöffer E., Fuhrmann P. Okulo-Pressions-Tonometrie (OPT)--ein neues tonographisches Verfahren zur Glaukomdiagnostik. Klin Monbl Augenheilkd. 1987 Feb;190(2):109–113. doi: 10.1055/s-2008-1050339. [DOI] [PubMed] [Google Scholar]
  20. Weinreb R. N., Lusky M., Bartsch D. U., Morsman D. Effect of repetitive imaging on topographic measurements of the optic nerve head. Arch Ophthalmol. 1993 May;111(5):636–638. doi: 10.1001/archopht.1993.01090050070031. [DOI] [PubMed] [Google Scholar]
  21. Woo S. L., Kobayashi A. S., Schlegel W. A., Lawrence C. Nonlinear material properties of intact cornea and sclera. Exp Eye Res. 1972 Jul;14(1):29–39. doi: 10.1016/0014-4835(72)90139-x. [DOI] [PubMed] [Google Scholar]
  22. Zeimer R. C., Ogura Y. The relation between glaucomatous damage and optic nerve head mechanical compliance. Arch Ophthalmol. 1989 Aug;107(8):1232–1234. doi: 10.1001/archopht.1989.01070020298042. [DOI] [PubMed] [Google Scholar]

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