Skip to main content
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1998 Sep;82(9):1083–1089. doi: 10.1136/bjo.82.9.1083

Glaucoma drainage devices; past, present, and future

K Lim 1, B Allan 1, A Lloyd 1, A Muir 1, P Khaw 1, K LIM 1, B ALLAN 1, A LLOYD 1, A MUIR 1, P KHAW 1
PMCID: PMC1722728  PMID: 9893602

Full Text

The Full Text of this article is available as a PDF (165.3 KB).

Figure 1  .

Figure 1  

(A) Single plate Molteno implant (scale bar = 1 cm). (B) Dual chamber double plate Molteno implant (scale bar = 1 cm). (C) Schematic drawing of the resistance mechanism of a dual chamber single plate Molteno implant. The thin V-shaped ridge (see B) has the same height as the circumferential rim of the polypropylene plate. The top surface of the plate is divided into one smaller and one larger chamber by the apposition of the overlying conjunctival and Tenon's layers (dotted line). Aqueous flows (black arrow) into the smaller proximal chamber until sufficient pressure is achieved within the chamber to lift (white arrow) the overlying conjunctival layer to allow free drainage.

Figure 2  .

Figure 2  

(A) The Krupin valve with disc, slit valve is situated at the plate end of the tube (scale bar = 1 cm). (B) A schematic drawing of the Krupin slit valve, showing the crossed slit elements.

Figure 3  .

Figure 3  

(A) The Baerveldt implant (scale bar = 1 cm). (B) Schematic drawing of the appositional resistance mechanism included in some embodiments of the Baerveldt GDD. An annular ridge projecting from the underside of the plate element provides a temporary seal against the sclera. Absorbable sutures are used to hold the plate in apposition. As the sutures degrade, the plate element lifts clear, allowing free aqueous drainage.

Figure 4  .

Figure 4  

(A) The Ahmed glaucoma valve implant (scale bar = 1 cm). (B) Schematic drawing of the resistance mechanism of the Ahmed valve. Aqueous flows (black arrow) through the tube into a chamber within the plate element. This chamber is formed by a folded over silicone membrane (black line) with its free edges forming a one way valve. Manufacturers claim that the two halves of the polypropylene body of the plate element pre-tension the valve to open at a specific level of intraocular pressure. They also claim that the venturi effect produced by the tapering trapezoidal shape of the space enclosed by the folded silicone membrane acts to improve flow regulation (increasing fluid velocity as the chamber tapers acts to reduce internal pressure proximal to the slit opening in accordance with the inverse relation between fluid velocity and pressure expressed in the Bernoulli's theorem). Neither of these claims is supported by the published experimental evidence.

Figure 5  .

Figure 5  

(A) The OptiMed implant is made up of a silicone tube with a PMMA plate. The "flow restricting" element of this device is housed within the rectangular box situated at the end of the tube within the plate (scale bar = 1 cm). (B) Schematic drawing of the OptiMed implant's "flow restricting" unit which is made up of multiple microtubules providing a pressure gradient governed by Poiseuille's formula.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allan B. D., van Saarloos P. P., Cooper R. L., Constable I. J. 193 nm excimer laser sclerostomy in pseudophakic patients with advanced open angle glaucoma. Br J Ophthalmol. 1994 Mar;78(3):199–205. doi: 10.1136/bjo.78.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BICK M. W. Use of tantalum for ocular drainage. Arch Ophthal. 1949 Oct;42(4):373–388. doi: 10.1001/archopht.1949.00900050381003. [DOI] [PubMed] [Google Scholar]
  3. BIETTI G. B. The present state of the use of plastics in eye surgery. Acta Ophthalmol (Copenh) 1955;33(4):337–370. doi: 10.1111/j.1755-3768.1955.tb00073.x. [DOI] [PubMed] [Google Scholar]
  4. Blondeau P., Phelps C. D. Trabeculectomy vs thermosclerostomy. A randomized prospective clinical trial. Arch Ophthalmol. 1981 May;99(5):810–816. doi: 10.1001/archopht.1981.03930010810003. [DOI] [PubMed] [Google Scholar]
  5. Cairns J. E. Trabeculectomy. Preliminary report of a new method. Am J Ophthalmol. 1968 Oct;66(4):673–679. [PubMed] [Google Scholar]
  6. Cheung J. C., Wright M. M., Murali S., Pederson J. E. Intermediate-term outcome of variable dose mitomycin C filtering surgery. Ophthalmology. 1997 Jan;104(1):143–149. doi: 10.1016/s0161-6420(97)30347-9. [DOI] [PubMed] [Google Scholar]
  7. Coleman A. L., Hill R., Wilson M. R., Choplin N., Kotas-Neumann R., Tam M., Bacharach J., Panek W. C. Initial clinical experience with the Ahmed Glaucoma Valve implant. Am J Ophthalmol. 1995 Jul;120(1):23–31. doi: 10.1016/s0002-9394(14)73755-9. [DOI] [PubMed] [Google Scholar]
  8. Coleman A. L., Mondino B. J., Wilson M. R., Casey R. Clinical experience with the Ahmed Glaucoma Valve implant in eyes with prior or concurrent penetrating keratoplasties. Am J Ophthalmol. 1997 Jan;123(1):54–61. doi: 10.1016/s0002-9394(14)70992-4. [DOI] [PubMed] [Google Scholar]
  9. Coleman A. L., Smyth R. J., Wilson M. R., Tam M. Initial clinical experience with the Ahmed Glaucoma Valve implant in pediatric patients. Arch Ophthalmol. 1997 Feb;115(2):186–191. doi: 10.1001/archopht.1997.01100150188007. [DOI] [PubMed] [Google Scholar]
  10. Costa V. P., Smith M., Spaeth G. L., Gandham S., Markovitz B. Loss of visual acuity after trabeculectomy. Ophthalmology. 1993 May;100(5):599–612. doi: 10.1016/s0161-6420(93)31597-6. [DOI] [PubMed] [Google Scholar]
  11. Egbert P. R., Lieberman M. F. Internal suture occlusion of the Molteno glaucoma implant for the prevention of postoperative hypotony. Ophthalmic Surg. 1989 Jan;20(1):53–56. [PubMed] [Google Scholar]
  12. Fellenbaum P. S., Almeida A. R., Minckler D. S., Sidoti P. A., Baerveldt G., Heuer D. K. Krupin disk implantation for complicated glaucomas. Ophthalmology. 1994 Jul;101(7):1178–1182. doi: 10.1016/s0161-6420(13)31724-2. [DOI] [PubMed] [Google Scholar]
  13. Freedman J. Clinical experience with the Molteno dual-chamber single-plate implant. Ophthalmic Surg. 1992 Apr;23(4):238–241. [PubMed] [Google Scholar]
  14. Gibson G. G. Transscleral Lacrimal Canaliculus Transplants. Trans Am Ophthalmol Soc. 1942;40:499–515. [PMC free article] [PubMed] [Google Scholar]
  15. Grant W. M., Burke J. F., Jr Why do some people go blind from glaucoma? Ophthalmology. 1982 Sep;89(9):991–998. doi: 10.1016/s0161-6420(82)34675-8. [DOI] [PubMed] [Google Scholar]
  16. Hall B., Bird R. R., Kojima M., Chapman D. Biomembranes as models for polymer surfaces. V. Thrombelastographic studies of polymeric lipids and polyesters. Biomaterials. 1989 May;10(4):219–224. doi: 10.1016/0142-9612(89)90096-3. [DOI] [PubMed] [Google Scholar]
  17. Heuer D. K., Lloyd M. A., Abrams D. A., Baerveldt G., Minckler D. S., Lee M. B., Martone J. F. Which is better? One or two? A randomized clinical trial of single-plate versus double-plate Molteno implantation for glaucomas in aphakia and pseudophakia. Ophthalmology. 1992 Oct;99(10):1512–1519. doi: 10.1016/s0161-6420(92)31772-5. [DOI] [PubMed] [Google Scholar]
  18. Honrubia F. M., Grijalbo M. P., Gomez M. L., Lopez A. Surgical treatment of neovascular glaucoma. Trans Ophthalmol Soc U K. 1979 Apr;99(1):89–91. [PubMed] [Google Scholar]
  19. Ikada Y. Surface modification of polymers for medical applications. Biomaterials. 1994 Aug;15(10):725–736. doi: 10.1016/0142-9612(94)90025-6. [DOI] [PubMed] [Google Scholar]
  20. Jampel H. D., Leong K. W., Dunkelburger G. R., Quigley H. A. Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride disks. Arch Ophthalmol. 1990 Mar;108(3):430–435. doi: 10.1001/archopht.1990.01070050128046. [DOI] [PubMed] [Google Scholar]
  21. Jay J. L., Allan D. The benefit of early trabeculectomy versus conventional management in primary open angle glaucoma relative to severity of disease. Eye (Lond) 1989;3(Pt 5):528–535. doi: 10.1038/eye.1989.84. [DOI] [PubMed] [Google Scholar]
  22. Joseph J. P., Grierson I., Hitchings R. A. Partial characterization of the fibroblast chemotactic constituents of human aqueous humour. Int Ophthalmol. 1989 Jan;13(1-2):125–130. doi: 10.1007/BF02028652. [DOI] [PubMed] [Google Scholar]
  23. Joseph N. H., Sherwood M. B., Trantas G., Hitchings R. A., Lattimer L. A one-piece drainage system for glaucoma surgery. Trans Ophthalmol Soc U K. 1986;105(Pt 6):657–664. [PubMed] [Google Scholar]
  24. Kee C., Youn D. H. Experimentally designed glaucoma implant surgery with mitomycin C in rabbit. Korean J Ophthalmol. 1995 Dec;9(2):89–95. doi: 10.3341/kjo.1995.9.2.89. [DOI] [PubMed] [Google Scholar]
  25. Kim D. D., Memmen J. E. Spontaneous disengagement of the Optimed implant. Arch Ophthalmol. 1996 Nov;114(11):1420–1421. doi: 10.1001/archopht.1996.01100140620021. [DOI] [PubMed] [Google Scholar]
  26. Krawczyk C. H. Glaucoma drainage devices and the FDA. Ophthalmology. 1995 Nov;102(11):1581–1582. doi: 10.1016/s0161-6420(95)30825-1. [DOI] [PubMed] [Google Scholar]
  27. Krupin T., Podos S. M., Becker B., Newkirk J. B. Valve implants in filtering surgery. Am J Ophthalmol. 1976 Feb;81(2):232–235. doi: 10.1016/0002-9394(76)90737-6. [DOI] [PubMed] [Google Scholar]
  28. LOSCHE W. Vorschläge zur Verbesserung der Zyklodialyse. Klin Monbl Augenheilkd Augenarztl Fortbild. 1952;121(6):715–716. [PubMed] [Google Scholar]
  29. Lee P. F., Wong W. T. Aqueous-venous shunt for glaucoma: report on 15 cases. Ann Ophthalmol. 1974 Oct;6(10):1083–1088. [PubMed] [Google Scholar]
  30. Liebmann J. M., Sokol J., Ritch R. Management of chronic hypotony after glaucoma filtration surgery. J Glaucoma. 1996 Jun;5(3):210–220. [PubMed] [Google Scholar]
  31. Lloyd M. A., Baerveldt G., Fellenbaum P. S., Sidoti P. A., Minckler D. S., Martone J. F., LaBree L., Heuer D. K. Intermediate-term results of a randomized clinical trial of the 350- versus the 500-mm2 Baerveldt implant. Ophthalmology. 1994 Aug;101(8):1456–1464. doi: 10.1016/s0161-6420(94)31152-3. [DOI] [PubMed] [Google Scholar]
  32. Lloyd M. A., Sedlak T., Heuer D. K., Minckler D. S., Baerveldt G., Lee M. B., Martone J. F. Clinical experience with the single-plate Molteno implant in complicated glaucomas. Update of a pilot study. Ophthalmology. 1992 May;99(5):679–687. doi: 10.1016/s0161-6420(92)31910-4. [DOI] [PubMed] [Google Scholar]
  33. MULDOON W. E., RIPPLE P. H., WILDER H. C. Platinum implant in glaucoma surgery. AMA Arch Ophthalmol. 1951 Jun;45(6):666–672. doi: 10.1001/archopht.1951.01700010681008. [DOI] [PubMed] [Google Scholar]
  34. Mao L. K., Stewart W. C., Shields M. B. Correlation between intraocular pressure control and progressive glaucomatous damage in primary open-angle glaucoma. Am J Ophthalmol. 1991 Jan 15;111(1):51–55. doi: 10.1016/s0002-9394(14)76896-5. [DOI] [PubMed] [Google Scholar]
  35. Mascati N. T. A new surgical approach for the control of a class of glaucomas. Int Surg. 1967 Jan;47(1):10–15. [PubMed] [Google Scholar]
  36. Melamed S., Fiore P. M. Molteno implant surgery in refractory glaucoma. Surv Ophthalmol. 1990 May-Jun;34(6):441–448. doi: 10.1016/0039-6257(90)90124-e. [DOI] [PubMed] [Google Scholar]
  37. Mermoud A., Salmon J. F., Alexander P., Straker C., Murray A. D. Molteno tube implantation for neovascular glaucoma. Long-term results and factors influencing the outcome. Ophthalmology. 1993 Jun;100(6):897–902. [PubMed] [Google Scholar]
  38. Migdal C., Hitchings R. Morbidity following prolonged postoperative hypotony after trabeculectomy. Ophthalmic Surg. 1988 Dec;19(12):865–867. [PubMed] [Google Scholar]
  39. Migdal C. Rational choice of therapy in established open angle glaucoma. Eye (Lond) 1992;6(Pt 4):346–347. doi: 10.1038/eye.1992.70. [DOI] [PubMed] [Google Scholar]
  40. Miller M. H., Grierson I., Unger W. I., Hitchings R. A. Wound healing in an animal model of glaucoma fistulizing surgery in the rabbit. Ophthalmic Surg. 1989 May;20(5):350–357. [PubMed] [Google Scholar]
  41. Mills R. P., Reynolds A., Emond M. J., Barlow W. E., Leen M. M. Long-term survival of Molteno glaucoma drainage devices. Ophthalmology. 1996 Feb;103(2):299–305. doi: 10.1016/s0161-6420(96)30700-8. [DOI] [PubMed] [Google Scholar]
  42. Minckler D. S., Heuer D. K., Hasty B., Baerveldt G., Cutting R. C., Barlow W. E. Clinical experience with the single-plate Molteno implant in complicated glaucomas. Ophthalmology. 1988 Sep;95(9):1181–1188. doi: 10.1016/s0161-6420(88)33029-0. [DOI] [PubMed] [Google Scholar]
  43. Minckler D. S., Shammas A., Wilcox M., Ogden T. E. Experimental studies of aqueous filtration using the Molteno implant. Trans Am Ophthalmol Soc. 1987;85:368–392. [PMC free article] [PubMed] [Google Scholar]
  44. Molteno A. C. New implant for drainage in glaucoma. Animal trial. Br J Ophthalmol. 1969 Mar;53(3):161–168. doi: 10.1136/bjo.53.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Molteno A. C., Polkinghorne P. J., Bowbyes J. A. The vicryl tie technique for inserting a draining implant in the treatment of secondary glaucoma. Aust N Z J Ophthalmol. 1986 Nov;14(4):343–354. doi: 10.1111/j.1442-9071.1986.tb00470.x. [DOI] [PubMed] [Google Scholar]
  46. Molteno A. C., Straughan J. L., Ancker E. Long tube implants in the management of glaucoma. S Afr Med J. 1976 Jun 26;50(27):1062–1066. [PubMed] [Google Scholar]
  47. Molteno A. C. The optimal design of drainage implants for glaucoma. Trans Ophthalmol Soc N Z. 1981;33:39–41. [PubMed] [Google Scholar]
  48. Molteno A. C., Van Rooyen M. M., Bartholomew R. S. Implants for draining neovascular glaucoma. Br J Ophthalmol. 1977 Feb;61(2):120–125. doi: 10.1136/bjo.61.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Pandya A. D., Rich C., Eifrig D. E., Hanker J., Peiffer R. L. Experimental evaluation of a hydroxylapatite reservoir tube shunt in rabbits. Ophthalmic Surg Lasers. 1996 Apr;27(4):308–314. [PubMed] [Google Scholar]
  50. Paysse E., Lee P. P., Lloyd M. A., Sidoti P. A., Fellenbaum P. S., Baerveldt G., Minckler D. S., Heuer D. K. Suprachoroidal hemorrhage after Molteno implantation. J Glaucoma. 1996 Jun;5(3):170–175. [PubMed] [Google Scholar]
  51. Perkins T. W., Cardakli U. F., Eisele J. R., Kaufman P. L., Heatley G. A. Adjunctive mitomycin C in Molteno implant surgery. Ophthalmology. 1995 Jan;102(1):91–97. doi: 10.1016/s0161-6420(95)31048-2. [DOI] [PubMed] [Google Scholar]
  52. Porter J. M., Krawczyk C. H., Carey R. F. In vitro flow testing of glaucoma drainage devices. Ophthalmology. 1997 Oct;104(10):1701–1707. doi: 10.1016/s0161-6420(97)30077-3. [DOI] [PubMed] [Google Scholar]
  53. Prata J. A., Jr, Minckler D. S., Mermoud A., Baerveldt G. Effects of intraoperative mitomycin-C on the function of Baerveldt glaucoma drainage implants in rabbits. J Glaucoma. 1996 Feb;5(1):29–38. [PubMed] [Google Scholar]
  54. Prata J. A., Jr, Mérmoud A., LaBree L., Minckler D. S. In vitro and in vivo flow characteristics of glaucoma drainage implants. Ophthalmology. 1995 Jun;102(6):894–904. doi: 10.1016/s0161-6420(95)30937-2. [DOI] [PubMed] [Google Scholar]
  55. Price F. W., Jr, Whitson W. E. Polypropylene ligatures as a means of controlling intraocular pressure with Molteno implants. Ophthalmic Surg. 1989 Nov;20(11):781–783. [PubMed] [Google Scholar]
  56. Schocket S. S., Lakhanpal V., Richards R. D. Anterior chamber tube shunt to an encircling band in the treatment of neovascular glaucoma. Ophthalmology. 1982 Oct;89(10):1188–1194. doi: 10.1016/s0161-6420(82)34671-0. [DOI] [PubMed] [Google Scholar]
  57. Sidoti P. A., Dunphy T. R., Baerveldt G., LaBree L., Minckler D. S., Lee P. P., Heuer D. K. Experience with the Baerveldt glaucoma implant in treating neovascular glaucoma. Ophthalmology. 1995 Jul;102(7):1107–1118. doi: 10.1016/s0161-6420(95)30904-9. [DOI] [PubMed] [Google Scholar]
  58. Siegner S. W., Netland P. A., Urban R. C., Jr, Williams A. S., Richards D. W., Latina M. A., Brandt J. D. Clinical experience with the Baerveldt glaucoma drainage implant. Ophthalmology. 1995 Sep;102(9):1298–1307. doi: 10.1016/s0161-6420(95)30871-8. [DOI] [PubMed] [Google Scholar]
  59. Skuta G. L., Beeson C. C., Higginbotham E. J., Lichter P. R., Musch D. C., Bergstrom T. J., Klein T. B., Falck F. Y., Jr Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. Ophthalmology. 1992 Mar;99(3):438–444. doi: 10.1016/s0161-6420(92)31951-7. [DOI] [PubMed] [Google Scholar]
  60. Smith S. G., Galanis J. C. One-year results of the intrascleral glaucoma implant. J Cataract Refract Surg. 1995 Jul;21(4):453–456. doi: 10.1016/s0886-3350(13)80539-1. [DOI] [PubMed] [Google Scholar]
  61. Smith S. L., Starita R. J., Fellman R. L., Lynn J. R. Early clinical experience with the Baerveldt 350-mm2 glaucoma implant and associated extraocular muscle imbalance. Ophthalmology. 1993 Jun;100(6):914–918. doi: 10.1016/s0161-6420(93)31554-x. [DOI] [PubMed] [Google Scholar]
  62. Smith S. L., Starita R. J., Fellman R. L., Lynn J. R. Early clinical experience with the Baerveldt 350-mm2 glaucoma implant and associated extraocular muscle imbalance. Ophthalmology. 1993 Jun;100(6):914–918. doi: 10.1016/s0161-6420(93)31554-x. [DOI] [PubMed] [Google Scholar]
  63. Stamper R. L., McMenemy M. G., Lieberman M. F. Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil. Am J Ophthalmol. 1992 Nov 15;114(5):544–553. doi: 10.1016/s0002-9394(14)74481-2. [DOI] [PubMed] [Google Scholar]
  64. Susanna R., Jr, Nicolela M. T., Takahashi W. Y. Mitomycin C as adjunctive therapy with glaucoma implant surgery. Ophthalmic Surg. 1994 Jul;25(7):458–462. [PubMed] [Google Scholar]
  65. Tang L., Eaton J. W. Fibrin(ogen) mediates acute inflammatory responses to biomaterials. J Exp Med. 1993 Dec 1;178(6):2147–2156. doi: 10.1084/jem.178.6.2147. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES