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. 1999 Jan;83(1):50–53. doi: 10.1136/bjo.83.1.50

Arterial blood flow characteristics in central retinal vein occlusion and effects of panretinal photocoagulation treatment: an investigation by colour Doppler imaging

A M Avunduk 1, H Dinc 1, Z Kapicioglu 1, S Ugurlu 1, V Dayanir 1, E Korkmaz 1
PMCID: PMC1722785  PMID: 10209435

Abstract

AIMS—To determine whether an increase in vascular resistance in the central retinal and ophthalmic arterial circulations contributes to the development of central retinal vein occlusion (CRVO), or haemodynamic alterations in central retinal and ophthalmic arteries occur secondary to the vein occlusion as increased intravascular pressure is transferred through the capillary bed to the arterial side and the effect of panretinal photocoagulation treatment on these circulations in ischaemic cases.
METHODS—The ophthalmic and central retinal arteries of the affected and non-affected eyes of 20 patients with non-ischaemic CRVO, 13 patients with ischaemic CRVO, and 22 control subjects were investigated by colour Doppler imaging. Panretinal photocoagulation (PRP) treatment was applied to the eyes with ischaemic CRVO. Maximum and minimum blood flow velocities, and resistivity indexes were calculated in the affected and healthy eyes of patients and in the control eyes.
RESULTS—Average blood flow velocity in the central retinal and ophthalmic arteries of patients with non-ischaemic CRVO did not differ from their fellow eyes, but a significantly lower average blood flow velocity was found in the ophthalmic and central retinal arteries of the patients with ischaemic CRVO compared with their fellow eyes. Patients with ischaemic CRVO had significantly lower blood flow velocities in their ophthalmic and central retinal arteries than non-ischaemic cases that were further reduced following PRP treatment.
CONCLUSION—This study suggests that impaired arterial blood flow observed in patients with CRVO may be partly related to secondary changes in the retrobulbar arterial circulation as a result of enhanced arterial resistance following CRVO. These data also demonstrate that PRP treatment decreases retinal and ophthalmic blood flow velocities in patients with ischaemic CRVO.

 Keywords: central retinal vein occlusion; panretinal photocoagulation; arterial circulation; colour Doppler imaging

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Selected References

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  1. Aburn N. S., Sergott R. C. Orbital colour Doppler imaging. Eye (Lond) 1993;7(Pt 5):639–647. doi: 10.1038/eye.1993.147. [DOI] [PubMed] [Google Scholar]
  2. Elman M. J., Bhatt A. K., Quinlan P. M., Enger C. The risk for systemic vascular diseases and mortality in patients with central retinal vein occlusion. Ophthalmology. 1990 Nov;97(11):1543–1548. doi: 10.1016/s0161-6420(90)32379-5. [DOI] [PubMed] [Google Scholar]
  3. Fujino T., Curtin V. T., Norton E. W. Experimental central retinal vein occlusion. A comparison of intraocular and extraocular occlusion. Arch Ophthalmol. 1969 Mar;81(3):395–406. doi: 10.1001/archopht.1969.00990010397018. [DOI] [PubMed] [Google Scholar]
  4. Green W. R., Chan C. C., Hutchins G. M., Terry J. M. Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Trans Am Ophthalmol Soc. 1981;79:371–422. [PMC free article] [PubMed] [Google Scholar]
  5. Grunwald J. E., Brucker A. J., Petrig B. L., Riva C. E. Retinal blood flow regulation and the clinical response to panretinal photocoagulation in proliferative diabetic retinopathy. Ophthalmology. 1989 Oct;96(10):1518–1522. doi: 10.1016/s0161-6420(89)32697-2. [DOI] [PubMed] [Google Scholar]
  6. Güven D., Ozdemir H., Hasanreisoglu B. Hemodynamic alterations in diabetic retinopathy. Ophthalmology. 1996 Aug;103(8):1245–1249. doi: 10.1016/s0161-6420(96)30514-9. [DOI] [PubMed] [Google Scholar]
  7. Hayreh S. S. Classification of central retinal vein occlusion. Ophthalmology. 1983 May;90(5):458–474. doi: 10.1016/s0161-6420(83)34530-9. [DOI] [PubMed] [Google Scholar]
  8. Hayreh S. S. Pathogenesis of occlusion of the central retinal vessels. Am J Ophthalmol. 1971 Nov;72(5):998–1011. doi: 10.1016/0002-9394(71)91706-5. [DOI] [PubMed] [Google Scholar]
  9. Hayreh S. S., Rojas P., Podhajsky P., Montague P., Woolson R. F. Ocular neovascularization with retinal vascular occlusion-III. Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology. 1983 May;90(5):488–506. doi: 10.1016/s0161-6420(83)34542-5. [DOI] [PubMed] [Google Scholar]
  10. Hayreh S. S. So-called "central retinal vein occlusion". I. Pathogenesis, terminology, clinical features. Ophthalmologica. 1976;172(1):1–13. doi: 10.1159/000307579. [DOI] [PubMed] [Google Scholar]
  11. Hayreh S. S., van Heuven W. A., Hayreh M. S. Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. Arch Ophthalmol. 1978 Feb;96(2):311–323. doi: 10.1001/archopht.1978.03910050179015. [DOI] [PubMed] [Google Scholar]
  12. Ho A. C., Lieb W. E., Flaharty P. M., Sergott R. C., Brown G. C., Bosley T. M., Savino P. J. Color Doppler imaging of the ocular ischemic syndrome. Ophthalmology. 1992 Sep;99(9):1453–1462. doi: 10.1016/s0161-6420(92)31784-1. [DOI] [PubMed] [Google Scholar]
  13. Jorizzo P. A., Klein M. L., Shults W. T., Linn M. L. Visual recovery in combined central retinal artery and central retinal vein occlusion. Am J Ophthalmol. 1987 Oct 15;104(4):358–363. doi: 10.1016/0002-9394(87)90225-x. [DOI] [PubMed] [Google Scholar]
  14. Keyser B. J., Flaharty P. M., Sergott R. C., Brown G. C., Lieb W. E., Annesley W. H., Jr Color Doppler imaging of arterial blood flow in central retinal vein occlusion. Ophthalmology. 1994 Aug;101(8):1357–1361. doi: 10.1016/s0161-6420(94)31161-4. [DOI] [PubMed] [Google Scholar]
  15. Laatikainen L., Kohner E. M., Khoury D., Blach R. K. Panretinal photocoagulation in central retinal vein occlusion: A randomised controlled clinical study. Br J Ophthalmol. 1977 Dec;61(12):741–753. doi: 10.1136/bjo.61.12.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lieb W. E., Cohen S. M., Merton D. A., Shields J. A., Mitchell D. G., Goldberg B. B. Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol. 1991 Apr;109(4):527–531. doi: 10.1001/archopht.1991.01080040095036. [DOI] [PubMed] [Google Scholar]
  17. Lieb W. E. Color Doppler ultrasonography of the eye and orbit. Curr Opin Ophthalmol. 1993 Jun;4(3):68–75. doi: 10.1097/00055735-199306000-00012. [DOI] [PubMed] [Google Scholar]
  18. Magargal L. E., Brown G. C., Augsburger J. J., Parrish R. K., 2nd Neovascular glaucoma following central retinal vein obstruction. Ophthalmology. 1981 Nov;88(11):1095–1101. doi: 10.1016/s0161-6420(81)34901-x. [DOI] [PubMed] [Google Scholar]
  19. May D. R., Klein M. L., Peyman G. A. A prospective study of xenon arc photocoagulation for central retinal vein occlusion. Br J Ophthalmol. 1976 Dec;60(12):816–818. doi: 10.1136/bjo.60.12.816. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Paton A., Rubinstein K., Smith V. H. Arterial insufficiency in retinal venous occlusion (a short symposium). Trans Ophthalmol Soc U K. 1964;84:559–595. [PubMed] [Google Scholar]
  21. Pichot O., Gonzalvez B., Franco A., Mouillon M. Apport de l'echo-Doppler couleur a l'etude des pathologies vasculaires orbitaires et oculaires. J Fr Ophtalmol. 1996;19(1):19–31. [PubMed] [Google Scholar]
  22. Quinlan P. M., Elman M. J., Bhatt A. K., Mardesich P., Enger C. The natural course of central retinal vein occlusion. Am J Ophthalmol. 1990 Aug 15;110(2):118–123. doi: 10.1016/s0002-9394(14)76979-x. [DOI] [PubMed] [Google Scholar]
  23. Regillo C. D., Sergott R. C., Ho A. C., Belmont J. B., Fischer D. H. Hemodynamic alterations in the acute retinal necrosis syndrome. Ophthalmology. 1993 Aug;100(8):1171–1176. doi: 10.1016/s0161-6420(93)31510-1. [DOI] [PubMed] [Google Scholar]
  24. Rubinstein K., Jones E. B. Retinal vein occlusion: long-term prospects: 10 years' follow-up of 143 patients. Br J Ophthalmol. 1976 Feb;60(2):148–150. doi: 10.1136/bjo.60.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Trope G. E., Lowe G. D., McArdle B. M., Douglas J. T., Forbes C. D., Prentice C. M., Foulds W. S. Abnormal blood viscosity and haemostasis in long-standing retinal vein occlusion. Br J Ophthalmol. 1983 Mar;67(3):137–142. doi: 10.1136/bjo.67.3.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Williamson T. H., Baxter G. M. Central retinal vein occlusion, an investigation by color Doppler imaging. Blood velocity characteristics and prediction of iris neovascularization. Ophthalmology. 1994 Aug;101(8):1362–1372. doi: 10.1016/s0161-6420(94)31173-0. [DOI] [PubMed] [Google Scholar]
  27. Zegarra H., Gutman F. A., Conforto J. The natural course of central retinal vein occlusion. Ophthalmology. 1979 Nov;86(11):1931–1942. doi: 10.1016/s0161-6420(79)35327-1. [DOI] [PubMed] [Google Scholar]

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