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. 1999 Oct;83(10):1183–1185. doi: 10.1136/bjo.83.10.1183

Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid

O Cekic 1, C Batman 1, U Yasar 1, Y Totan 1, N Basci 1, A Bozkurt 1, O Zilelioglu 1, S Kayaalp 1
PMCID: PMC1722819  PMID: 10502583

Abstract

AIMS—To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration.
METHODS—31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were analysed for drug level by using high performance liquid chromatography.
RESULTS—SRF drug levels after oral and combined administration were significantly higher than that after topical administration (p=0.0002 and p=0.0002, respectively) while there was no significant difference between oral and combined administration (p=0.0844).
CONCLUSIONS—Ocular bioavailability of ofloxacin in SRF after oral and combined administration is equivalent. The addition of oral ofloxacin to topical therapy increased drug SRF penetration sixfold.



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Figure 1  .

Figure 1  

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Comparison of subretinal fluid levels of ofloxacin obtained after different modes of administration.

Selected References

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