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. 1999 Feb;83(2):180–184. doi: 10.1136/bjo.83.2.180

Efficacy of nedocromil 2% versus fluorometholone 0.1%: a randomised, double masked trial comparing the effects on severe vernal keratoconjunctivitis

K Tabbara 1, S Al-Kharashi 1
PMCID: PMC1722917  PMID: 10396195

Abstract

AIMS—To compare the efficacy of topical nedocromil 2% with fluorometholone 0.1% in vernal keratoconjunctivitis (VKC).
METHODS—In a double masked random design, 24 patients with severe vernal keratoconjunctivitis were placed at random on nedocromil 2% eye drops in one eye and fluorometholone 0.1% in the fellow eye. At the end of the 2 week treatment period, the patient crossed over the eye drops (if asymptomatic in one eye), or continued with nedocromil sodium in both eyes (if asymptomatic in both eyes). All patients were examined weekly and ocular surface temperature recorded for a period of 6 weeks. 
RESULTS—Improvement in the watering, discharge, conjunctival hyperaemia, papillary hypertrophy, and Trantas' dots was noted in both groups, but overall fluorometholone was significantly more effective than nedocromil. Eyes treated with fluorometholone showed a significant decrease in ocular surface temperature compared with nedocromil treated eyes (p = 0.03).
CONCLUSIONS—Both nedocromil and fluorometholone were effective in ameliorating the signs and symptoms of vernal keratoconjunctivitis. No adverse effects were noted in the nedocromil group.

 Keywords: vernal keratoconjunctivitis; nedocromil; fluorometholone; ocular allergy

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Figure 1  .

Figure 1  

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The effects of nedocromil and fluorometholone on the symptoms in patients with vernal keratoconjunctivitis.

Figure 2  .

Figure 2  

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The effects of nedocromil and fluorometholone on the signs in patients with vernal keratoconjunctivitis.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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