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. 1999 Mar;83(3):280–284. doi: 10.1136/bjo.83.3.280

Age over 46 years does not affect the pressure lowering effect of trabeculectomy in primary open angle glaucoma

M Briggs 1, J Jay 1
PMCID: PMC1722971  PMID: 10365033

Abstract

BACKGROUND/AIMS—Previous reports have suggested that the success rate for trabeculectomy is poorer in younger age groups but these studies often have heterogeneous groups representing different types of glaucoma with variable surgical prognosis. Therefore, the relation between age and the success of trabeculectomy in the single diagnostic category of primary open angle glaucoma (POAG) without identifiable risk factors was examined for failure in the age range 46-85 years.
METHODS—The records of 208 patients who had undergone a first trabeculectomy for POAG were examined retrospectively. Age ranged from 46 to 85 (mean 66.7 years). The outcome of surgery was examined at final available follow up and at 1 and 2 years after surgery. Trabeculectomy was considered a success if intraocular pressure was ⩽21 mm Hg with or without additional medical treatment ("cumulative" success) and an "absolute" success if intraocular pressure was ⩽21 mm Hg without additional medical treatment.
RESULTS—Cumulative success for trabeculectomy was 92.3% at final follow up and 96.6% at 2 year follow up; absolute success rate was 66.3% at final follow up and 71.6% at 2 years. There was no significant trend for greater success of trabeculectomy in the older age groups (cumulative success at 2 year follow up, χ2 for linear trend 1.07(p=0.3) nor was the drop in intraocular pressure following surgery significantly greater with increasing age (analysis of variance for intraocular pressure lowering from presentation to 2 years' follow up (Kruskal-Wallis, t=5.9, p=0.55). Patients with pseudoexfoliation were excluded from the main analysis as these patients have been shown to have a lower final intraocular pressure following trabeculectomy, a finding which was confirmed in this study.
CONCLUSION—This study demonstrates that in the age range 46-85 years there is no demonstrable relation between age at the time of surgery and success of trabeculectomy in POAG

 Keywords: trabeculectomy; intraocular pressure; primary open angle glaucoma; age

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Figure 1  .

Figure 1  

Illustration of absolute and cumulative success rates at 1 and 2 year follow up.    

Figure 2  .

Figure 2  

Mean intraocular pressure at presentation and at 2 year follow up for each age group.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen R. C., Bellows A. R., Hutchinson B. T., Murphy S. D. Filtration surgery in the treatment of neovascular glaucoma. Ophthalmology. 1982 Oct;89(10):1181–1187. doi: 10.1016/s0161-6420(82)34672-2. [DOI] [PubMed] [Google Scholar]
  2. Broadway D. C., Grierson I., O'Brien C., Hitchings R. A. Adverse effects of topical antiglaucoma medication. II. The outcome of filtration surgery. Arch Ophthalmol. 1994 Nov;112(11):1446–1454. doi: 10.1001/archopht.1994.01090230060021. [DOI] [PubMed] [Google Scholar]
  3. Gressel M. G., Heuer D. K., Parrish R. K., 2nd Trabeculectomy in young patients. Ophthalmology. 1984 Oct;91(10):1242–1246. doi: 10.1016/s0161-6420(84)34179-3. [DOI] [PubMed] [Google Scholar]
  4. Inaba Z. Long-term results of trabeculectomy in the Japanese: an analysis by life-table method. Jpn J Ophthalmol. 1982;26(4):361–373. [PubMed] [Google Scholar]
  5. Jay J. L. Rational choice of therapy in primary open angle glaucoma. Eye (Lond) 1992;6(Pt 3):243–247. doi: 10.1038/eye.1992.47. [DOI] [PubMed] [Google Scholar]
  6. Jerndal T., Lundström M. 330 trabeculectomies. A long time study (3-5 1/2 years). Acta Ophthalmol (Copenh) 1980 Dec;58(6):947–956. doi: 10.1111/j.1755-3768.1980.tb08321.x. [DOI] [PubMed] [Google Scholar]
  7. Jones N. P. Glaucoma in Fuchs' Heterochromic Uveitis: aetiology, management and outcome. Eye (Lond) 1991;5(Pt 6):662–667. doi: 10.1038/eye.1991.122. [DOI] [PubMed] [Google Scholar]
  8. Konstas A. G., Jay J. L., Marshall G. E., Lee W. R. Prevalence, diagnostic features, and response to trabeculectomy in exfoliation glaucoma. Ophthalmology. 1993 May;100(5):619–627. doi: 10.1016/s0161-6420(93)31596-4. [DOI] [PubMed] [Google Scholar]
  9. Konstas A. G., Jay J. L. Modification of trabeculectomy to avoid postoperative hyphaema. The 'guarded anterior fistula' operation. Br J Ophthalmol. 1992 Jun;76(6):353–357. doi: 10.1136/bjo.76.6.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lamping K. A., Bellows A. R., Hutchinson B. T., Afran S. I. Long-term evaluation of initial filtration surgery. Ophthalmology. 1986 Jan;93(1):91–101. doi: 10.1016/s0161-6420(86)33771-0. [DOI] [PubMed] [Google Scholar]
  11. Lavin M. J., Wormald R. P., Migdal C. S., Hitchings R. A. The influence of prior therapy on the success of trabeculectomy. Arch Ophthalmol. 1990 Nov;108(11):1543–1548. doi: 10.1001/archopht.1990.01070130045027. [DOI] [PubMed] [Google Scholar]
  12. Miller R. D., Barber J. C. Trabeculectomy in black patients. Ophthalmic Surg. 1981 Jan;12(1):46–50. [PubMed] [Google Scholar]
  13. Morrell A. J., Searle A. E., O'Neill E. C. Trabeculectomy as an introduction to intraocular surgery in an ophthalmic training program. Ophthalmic Surg. 1989 Aug;20(8):557–560. [PubMed] [Google Scholar]
  14. Murray S. B., Jay J. L. Trabeculectomy. Its role in the management of glaucoma. Trans Ophthalmol Soc U K. 1979;99(4):492–494. [PubMed] [Google Scholar]
  15. Ridgway A. E. Trabeculectomy. A follow-up study. Br J Ophthalmol. 1974 Jul;58(7):680–686. doi: 10.1136/bjo.58.7.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schwartz A. L., Anderson D. R. Trabecular surgery. Arch Ophthalmol. 1974 Aug;92(2):134–138. doi: 10.1001/archopht.1974.01010010140012. [DOI] [PubMed] [Google Scholar]
  17. Shingleton B. J., Distler J. A., Baker B. H. Filtration surgery in black patients: early results in a West Indian population. Ophthalmic Surg. 1987 Mar;18(3):195–199. [PubMed] [Google Scholar]
  18. Stürmer J., Broadway D. C., Hitchings R. A. Young patient trabeculectomy. Assessment of risk factors for failure. Ophthalmology. 1993 Jun;100(6):928–939. doi: 10.1016/s0161-6420(93)31552-6. [DOI] [PubMed] [Google Scholar]
  19. Wilson P. Trabeculectomy: long-term follow-up. Br J Ophthalmol. 1977 Aug;61(8):535–538. doi: 10.1136/bjo.61.8.535. [DOI] [PMC free article] [PubMed] [Google Scholar]

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